Zhenghao Xu

ORCID: 0000-0003-0033-525X
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About
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Research Areas
  • Neuroscience and Neuropharmacology Research
  • Epilepsy research and treatment
  • Advanced Manufacturing and Logistics Optimization
  • Systemic Lupus Erythematosus Research
  • Neurological disorders and treatments
  • Plant and animal studies
  • Animal Nutrition and Physiology
  • Plant Diversity and Evolution
  • Plant and Fungal Species Descriptions
  • Neuroscience and Neural Engineering
  • SARS-CoV-2 and COVID-19 Research
  • Rheumatoid Arthritis Research and Therapies
  • COVID-19 Clinical Research Studies
  • Pharmacological Effects of Natural Compounds
  • Optimization and Search Problems
  • Heavy Metal Exposure and Toxicity
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Long-Term Effects of COVID-19
  • Photoreceptor and optogenetics research
  • Plant Pathogens and Fungal Diseases
  • Optimization and Packing Problems
  • Chemical synthesis and alkaloids
  • Biochemical effects in animals
  • Nicotinic Acetylcholine Receptors Study
  • Trace Elements in Health

Zhejiang Chinese Medical University
2016-2025

Chongqing Medical University
2024

The Affiliated Yongchuan Hospital of Chongqing Medical University
2024

Duke University
2024

Marcus (United States)
2024

Zhejiang University
2010-2023

Zhejiang Zanyu Technology (China)
2023

University of Massachusetts Chan Medical School
2021

Guangdong Academy of Agricultural Sciences
2020

Second Affiliated Hospital of Zhejiang University
2019

By engaging angiotensin-converting enzyme 2 (ACE2 or Ace2), the novel pathogenic severe acute respiratory syndrome coronavirus (SARS-CoV-2) invades host cells and affects many organs, including brain. However, distribution of ACE2 in brain is still obscure. Here, we investigated expression by analyzing data from publicly available transcriptome databases. According to our spatial analysis, was relatively highly expressed some locations, such as choroid plexus paraventricular nuclei thalamus....

10.3389/fneur.2020.573095 article EN cc-by Frontiers in Neurology 2021-01-20

Abstract By engaging angiotensin-converting enzyme 2 (ACE2 or Ace2), the novel pathogenic SARS-coronavirus (SARS-CoV-2) may invade host cells in many organs, including brain. However, distribution of ACE2 brain is still obscure. Here we investigated expression by analyzing data from publicly available transcriptome databases. According to our spatial analysis, was relatively highly expressed some locations, such as choroid plexus and paraventricular nuclei thalamus. cell-type nuclear found...

10.1101/2020.04.07.030650 preprint EN cc-by-nc-nd bioRxiv (Cold Spring Harbor Laboratory) 2020-04-09

Avian commercial male broiler chicks (n = 240), 1 d of age, were used to investigate the effects copper-bearing montmorillonite (Cu-MMT) on growth performance, digestive enzyme activities, and intestinal microflora morphology. The allocated 4 treatments, each which had 5 pens 12 per pen. treatments basal diet only (control group), + 1.5 g/kg (MMT), 36.75 mg/kg Cu, in form CuSO4, Cu-MMT. results showed that supplementation with Cu-MMT significantly improved performance compared control diet,...

10.1093/ps/83.11.1868 article EN cc-by-nc-nd Poultry Science 2004-11-01

A safe and effective therapy for epilepsy requires a drug delivery system that can penetrate the blood-brain barrier subsequently release antiepileptic drugs rapidly to suppress neuronal discharges in timely manner. We have developed electro-responsive hydrogel nanoparticles (ERHNPs) modified with angiopep-2 (ANG) facilitate of phenytoin sodium. The resulting ANG-ERHNPs had an average diameter (102.3±16.8) nm were electro-sensitive regard particle size vitro. characteristics BBB easily,...

10.1002/anie.201403846 article EN Angewandte Chemie International Edition 2014-07-18

The experiment was performed to compare the effects of fermented soybean meal (fermented with Aspergillus oryzae 3.042, FSBM) and on digestive enzyme activities intestinal morphology in broilers. Three hundred twenty 1-d-old Ross x male broiler chicks were randomly allocated into 2 dietary treatments for a 6-wk feeding trial, including 0- 21-d 21- 42-d periods. At end each stage, 8 broilers treatment killed, pancreas, small intestine digesta, duodenum, jejunum, ileum segments collected...

10.1093/ps/86.6.1149 article EN cc-by-nc-nd Poultry Science 2007-06-01

A total of 90 weanling female pigs (Duroc x Landrace Yorkshire) were used in a 30-d growth experiment to investigate the effect lactoferrin (LF) on performance, immune function, and serum iron concentrations. The allocated basis BW litter 3 dietary treatments randomized complete block design. were: control group (basal diet), antibiotics diet + 20 mg/kg flavomycin 110 aureomycin), LF 1.0 g/kg LF). There replicate pens per treatment, grouped with 10 pen. Six pigs, randomly selected from each...

10.2527/jas.2006-754 article EN Journal of Animal Science 2007-08-13

Brain stimulation is an alternative treatment for epilepsy. However, the neuronal circuits underlying its mechanisms remain obscure. We found that optogenetic activation (1Hz) of entorhinal calcium/calmodulin-dependent protein kinase II α (CaMKIIα)-positive neurons, but not GABAergic retarded hippocampal epileptogenesis and reduced seizure severity, similar to low-frequency electrical (LFES). Optogenetic inhibition CaMKIIα-positive neurons blocked antiepileptic effect LFES. The...

10.1016/j.ebiom.2016.11.027 article EN cc-by EBioMedicine 2016-11-23

Summary This study was conducted to determine whether chromium nanoparticle (CrNano) exhibited higher absorption efficiency and possessed unique mechanism in comparison picolinate (CrPic) chloride (CrCl 3 ), as postulated by previous reports. Twenty‐one‐day‐old Caco‐2 cell monolayers grown on semipermeable membranes Snapwell tissue culture bichambers were incubated with CrNano, CrPic or CrCl examine their transport uptake respectively. In the concentration range of 0.2–20 μ mol/l, across...

10.1111/j.1439-0396.2007.00718.x article EN Journal of Animal Physiology and Animal Nutrition 2007-07-11

The oocytes (experiment 1) were harvested by one of the four collection techniques (slicing, puncture, aspiration I and II) total number each grade counted, respectively. good-quality (good fair grade) cultured for maturation. In experiment 2, matured in TCM-199 supplemented with 10 ng/ml epidermal growth factor (EGF) or 10% FCS, either alone 1 IU/ml FSH, FSH. After maturation, two experiments fertilized, Slicing (6.3) puncture (5.8) ovaries yielded a higher (P < 0.05) per ovary compared to...

10.17221/2327-cjas article EN cc-by-nc Czech Journal of Animal Science 2007-01-31
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