A5049701117- Maternal Mental Health During Pregnancy and Postpartum
- Extracellular vesicles in disease
- Neuroscience and Neuropharmacology Research
- Maternal and Perinatal Health Interventions
- Cancer-related molecular mechanisms research
- Osteoarthritis Treatment and Mechanisms
- COVID-19 and Mental Health
- Adenosine and Purinergic Signaling
- Family Support in Illness
- Shoulder Injury and Treatment
- Cancer survivorship and care
- COVID-19 Impact on Reproduction
- Enhanced Recovery After Surgery
- Pancreatic function and diabetes
- Nutrition and Health in Aging
- Mesenchymal stem cell research
- Shoulder and Clavicle Injuries
- Ion channel regulation and function
- RNA modifications and cancer
- Autophagy in Disease and Therapy
- Child Nutrition and Feeding Issues
- Calcium signaling and nucleotide metabolism
- Pregnancy-related medical research
- Breastfeeding Practices and Influences
- Cardiac, Anesthesia and Surgical Outcomes
Sun Yat-sen University
2015-2025
Sichuan University
2016-2025
Third Affiliated Hospital of Sun Yat-sen University
2012-2025
West China Second University Hospital of Sichuan University
2015-2025
Seventh People's Hospital of Shanghai
2025
First Affiliated Hospital of Xi'an Jiaotong University
2025
State Key Laboratory of Remote Sensing Science
2024
Lincoln University College
2024
Third Affiliated Hospital of Guangzhou Medical University
2024
Bridge University
2024
Inflammatory damage contributes to β cell failure in type 1 and 2 diabetes (T1D T2D, respectively). Mitochondria are damaged by inflammatory signaling cells, resulting impaired bioenergetics initiation of proapoptotic machinery. Hence, the identification protective responses inflammation could lead new therapeutic targets. Here, we report that mitophagy serves as a response stress both human rodent cells. Utilizing vivo reporters, observed diabetogenic proinflammatory cytokines induced...
Most eukaryotic mRNAs contain a 5' cap (m7GpppX) and 3' poly(A) tail to increase synergistically the translational efficiency. Recently, binding protein (PABP) cap-binding protein, eIF-4F, were found interact [Le et al. (1997) J. Biol. Chem. 272, 16247−16255; Tarun Sachs (1996) EMBO 15, 7168−7177]. These data suggest that PABP may exert its effect on efficiency either by increasing formation of initiation factor−mRNA complex or enhancing ribosome recycling. To investigate functional...
Abstract To explore the association between infertility-related stress, family adaptability and cohesion in infertile couples determinants of stress couples. Fertility Problem Inventory (FPI) Family Adaptability Cohesion Evaluation Scales (FACESII-CV) were used to measure T-test, ANOVA multiple comparisons (LSD) conducted compare FPI scores different demographic characteristics subgroups. Stepwise multivariate linear regression was stress. Women had greater global than men ( P < 0.001)....
Mesenchymal stem cells (MSCs) have been described to induce angiogenesis in various tissues and used for the development of novel cell‐based therapies. Increasing evidence suggests that MSCs execute their paracrine function via secretion exosomes, especially under hypoxic conditions. However, mechanisms by which MSC‐derived exosomes secreted hypoxia enhance still remain unclear. To study exosome physiology or normoxic conditions, we isolated from bone marrow mesenchymal (BMSCs). Furthermore,...
P2X receptors are ATP-gated cation channels composed of one or more seven different subunits. ATP acts at to contribute fast excitatory postsynaptic potentials (fEPSPs) in myenteric neurons but the subunit composition enteric is unknown. These studies used tissues from P2X2 wild-type (P2X2+/+) and gene knockout (P2X2-/-) mice investigate role this neurotransmission. Intracellular electrophysiological methods were record synaptic drug-induced responses ileal vitro. Drug-induced longitudinal...
P2X receptors are ATP-gated cation channels composed of one or more seven different subunits. participate in intestinal neurotransmission but the subunit composition enteric is unknown. In this study, we used tissues from P2X3 wild-type (P2X3+/+) mice and which gene had been deleted (P2X3-/-) to investigate role intestine. RT-PCR analysis mRNA verified deletion. Intracellular electrophysiological methods were record synaptic drug-induced responses myenteric neurons vitro. Drug-induced...
In vitro and in vivo traumatic brain injury (TBI) alter the function expression of glutamate receptors, yet combined effect these alterations on cortical excitatory synaptic transmission is unclear. We examined mechanical cultured neurons by assaying synaptically driven intracellular free calcium ([Ca(2+)](i)) oscillations small neuronal networks as well spontaneous miniature postsynaptic currents (mEPSCs). show that decreased incidence frequency [Ca(2+)](i) for at least 2 days post-injury....
Osteoarthritis (OA) is a degenerative joint disease that affects both cartilage and bone. A better understanding of the early molecular changes in subchondral bone may help elucidate pathogenesis OA. We used microarray technology to investigate time course stages experimental osteoarthritis rat model. identified 2,234 differentially expressed (DE) genes at 1 week, 1,944 2 weeks 1,517 4 post-surgery. Further analyses dysregulated indicated events underlying remodeling occurred sequentially...
The beneficial effects of combined use mesenchymal stem cells ( MSC s) and endothelial progenitor EPC on tissue repair regeneration after injury have been demonstrated, but the underlying mechanism remains incompletely understood. This study aimed to investigate direct contact coculture human bone marrow‐derived EPCs (hEPCs)/human MSCs hMSC their proliferation angiogenic capacities mechanism. hEPC s were cocultured in a 2D mixed monolayer or 3D transwell membrane cell‐to‐cell system. Cell...
The aim of this study is to assess the depression pregnant women in aftermath an earthquake, and identify social support that they obtained, their coping styles socio-demographic factors associated with depression.A total 128 from three hospitals epicenter area were recruited immediately after Ya'an earthquake. Their was investigated using Edinburgh Postnatal Depression Scale (EPDS) a cutoff score 14; obtained measured Social Support Questionnaire; assessed Coping Styles...
Type 2 diabetes mellitus (T2DM) is characterized by impaired glucose-stimulated insulin secretion and increased peripheral resistance. Unremitting endoplasmic reticulum (ER) stress can lead to beta-cell apoptosis has been linked type diabetes. Although many studies have attempted link ER T2DM, the specific effects of on function remain incompletely understood. To determine interrelationship between function, here we treated insulin-secreting INS-1(832/13) cells or isolated mouse islets with...
In recent years, spiritual well-being has gradually gained the attention of health care providers in China, especially those oncology departments, who have recognized importance improving cancer patients. Since most current research on been carried out areas with religious beliefs, this study was conducted context no development formal religion. The purpose to explore relationship between death anxiety and related factors among gynecological patients.This cross-section 586 European...
Gap balancing is a vital process during mobile-bearing unicompartmental knee arthroplasty (MB-UKA). However, this commonly depends on the surgeon's experience and lacks specific unified standards. This study aimed to propose evaluate novel "measured resection" method for gap balance in MB-UKA. prospective included 49 consecutive patients (52 knees) who underwent MB-UKA from February 1, 2023, September 2023. was achieved by traditional "two-finger" (Group 26 or measured resection 2, knees)....
Occupational fatigue is a widespread condition within the nursing workforce, adversely affecting both nurses' health and patient safety. The protracted duration of COVID-19 pandemic, approaching 3 years, has exacerbated challenges faced by nurses globally. escalation in numbers high incidence infections among healthcare workers have intensified occupational fatigue. This study seeks to explore enduring impact pandemic on Chinese through latent profile analysis, identify associated risk...
Objective Presentation delay of cancer patients prevents the patient from timely diagnosis and treatment leading to poor prognosis. Predicting risk presentation is crucial improve outcomes. This study aimed develop validate prediction models in gastric by using various machine learning models. Methods 875 cases admitted a tertiary oncology hospital July 2023 June 2024 were used as derivation cohort, 200 other 4 external validation cohort. After collecting data, statistical analysis was...
Objective This study aimed to compare the knowledge, attitudes, and practices of parturients nurses regarding fall prevention among parturients, with goal understanding cognitive factors contributing post-delivery fall. Methods A cross-sectional survey was conducted obstetric women in ward within 2 days after vaginal delivery. The instrument included a self-design questionnaire comprising demographic information sheet KAP questionnaire, which demonstrated acceptable reliability validity....
Rationale: Conventional chemotherapies for B-cell malignancies are often limited by drug resistance and significant side effects due to non-specific targeting. This research aimed improve treatment efficacy developing nano-delivery systems that specifically target tumor cells, thereby enhancing therapeutic precision reducing off-target toxicity. Methods: The construction, biocompatibility, targeting capability of CD19@NP/17-DMAG were evaluated using TEM, HPLC, FTIR spectroscopy, CCK-8 assay,...
Huntingtin interacting protein 1 related (Hip1r) is an F-actin– and clathrin-binding involved in vesicular trafficking. In this study, we demonstrate that Hip1r abundantly expressed the gastric parietal cell, predominantly localizing with F-actin to canalicular membranes. may provide a critical function vivo, as demonstrated by extensive changes cells epithelium Hip1r-deficient mice. Electron microscopy revealed abnormal apical membranes loss of tubulovesicles mutant cells, suggesting...
Abstract Osteosarcoma (OS) is the most common primary solid malignant bone tumor, and its metastasis a prominent cause of high mortality in patients. In this study, prognosis risk signature was constructed based on metastasis‐associated genes. Four microarrays datasets with clinical information were downloaded from Gene Expression Omnibus, 256 genes identified by limma package. Further, protein‐protein interaction network constructed, survival analysis performed using data Therapeutically...
Angiogenesis is an essential step in tissue engineering. MSC exosomes play important role angiogenesis. Functional biomolecules vested by the culture microenvironment can be transferred to recipient cells and affects their effect. 3D improve proliferation activity of MSCs. However, whether derived from MSCs have enhanced effect on angiogenesis unclear. Herein, we compared bioactivity produced conventional 2D (2D-exos) (3D-exos) bone marrow stem (BMSCs) A series vitro vivo experiments...