A5101810699- Schizophrenia research and treatment
- Tryptophan and brain disorders
- Treatment of Major Depression
- Bipolar Disorder and Treatment
- Diet and metabolism studies
- Electroconvulsive Therapy Studies
- Neuroscience and Neuropharmacology Research
- Transcranial Magnetic Stimulation Studies
- Topological and Geometric Data Analysis
- Antibiotic Resistance in Bacteria
- Synthesis and biological activity
- Advanced Graph Neural Networks
- RNA Interference and Gene Delivery
- Gastrointestinal Tumor Research and Treatment
- Cell Image Analysis Techniques
- Attention Deficit Hyperactivity Disorder
- Leprosy Research and Treatment
- Advanced Computing and Algorithms
- Sphingolipid Metabolism and Signaling
- Maternal Mental Health During Pregnancy and Postpartum
- Synthesis and Reactions of Organic Compounds
- Nicotinic Acetylcholine Receptors Study
- Lipid Membrane Structure and Behavior
- Advanced Neuroimaging Techniques and Applications
- Neurotransmitter Receptor Influence on Behavior
Renmin University of China
2025
Xi'an Jiaotong University
2023
Shandong Mental Health Center
2018-2022
Beijing HuiLongGuan Hospital
2022
Peking University
2022
Jining First People's Hospital
2022
Shandong University
2022
Sichuan University
2014-2018
West China Hospital of Sichuan University
2014-2018
University of Southampton
2018
The aim of this study is to assess the depression pregnant women in aftermath an earthquake, and identify social support that they obtained, their coping styles socio-demographic factors associated with depression.A total 128 from three hospitals epicenter area were recruited immediately after Ya'an earthquake. Their was investigated using Edinburgh Postnatal Depression Scale (EPDS) a cutoff score 14; obtained measured Social Support Questionnaire; assessed Coping Styles...
The mechanisms underlying the effects of electroconvulsive therapy (ECT) in major depressive disorder (MDD) are not fully understood. Resting-state functional magnetic resonance imaging (rs-fMRI) is a new tool to study brain stimulation interventions, particularly ECT. authors aim investigate ECT MDD by rs-fMRI. They used rs-fMRI measure changes first-episode, treatment-naive patients (n = 23) immediately before and then following 8 sessions (brief-pulse square-wave apparatus, bitemporal)....
BACKGROUND:This study aimed to the brain structural and functional changes after 8 courses of electroconvulsive therapy (ECT) on patients with major depressive disorder (MDD). MATERIAL AND METHODS:MRI scans were performed 12 before ECT compared those 15 normal controls. Data analyzed by voxel-based morphometry (VBM) using SPM8 software. Functional MRI (fMRI) regional homogeneity (ReHo) analyses used assess ECT. RESULTS:Grey matter volumes smaller in right cingulate gyrus After false...
Objective . Electroconvulsive therapy (ECT) is considered one of the most effective and fast-acting treatment options for depressive episodes. Little known, however, about ECT’s enabling brain (neuro)plasticity effects, particular plasticity white matter pathway. Materials Methods We collected longitudinal diffusion tensor imaging in first-episode, drug-naïve major disorder (MDD) patients<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mfenced...
Genetic variabilities within the serotoninergic system may predict response or remission to antidepressant drugs. Several serotonin receptor (5-HTR) gene polymorphisms have been associated with susceptibility psychiatric diseases. In this study, we analyzed correlation between 5-HTR1A and 5-HTR2A selective reuptake inhibitors (SSRIs) drugs.Two hundred ninety patients who met Diagnostic Statistical Manual of Mental Disorders, Fourth Edition criteria for major depressive disorder were involved...
Background: Some previous studies have shown that weight gain is associated with greater improvement in psychopathology during antipsychotic treatment patients chronic schizophrenia. However, the results are mixed due to many confounding factors. The current study aimed investigate whether was response antipsychotic-naive and first-episode (ANFE) DSM-IV–diagnosed Methods: 526 ANFE 313 healthy controls were enrolled this study, which conducted from January 2012 December 2018. Treatment...
Background: Accumulating studies have shown that the pathophysiology of schizophrenia may be associated with aberrant lysophospolipid metabolism in early stage brain development. Recent evidence demonstrates antipsychotic medication can regulate phospholipase activity. However, it remains unclear whether is therapeutic response to schizophrenia. This study aimed investigate influence olanzapine monotherapy on lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE) association...
Oxidative stress plays an important role in weight gain induced by antipsychotics schizophrenia (SCZ). However, little is known about how antioxidant enzymes are involved caused risperidone monotherapy antipsychotics-naïve first-episode (ANFE) patients with SCZ. Therefore, the main purpose of this study was to investigate effects on several ANFE SCZ and relationship between changes enzyme activities.The activities plasma superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase...
There are various differences in response to different antipsychotics and antioxidant defense systems (ADS) by sex. Previous studies have shown that several ADS enzymes closely related the treatment of patients with antipsychotics-naïve first-episode (ANFE) schizophrenia.Therefore, main goal this study was assess sex difference relationship between changes enzyme activities risperidone response.The plasma glutathione peroxidase (GPx), catalase (CAT), superoxide dismutase (SOD), total status...
RNA polymerase mitochondrial (POLRMT) expression and the potential biological functions in skin squamous cell carcinoma (SCC) were explored. We showed that POLRMT is significantly elevated SCC. Genetic depletion of POLRMT, using shRNA-induced knockdown or CRISPR/Cas9-mediated knockout (KO), resulted profound anti-skin SCC activity. In patient-derived primary cells immortalized lines (A431 SCC-9), shRNA KO potently suppressed DNA (mtDNA) transcription viability, proliferation migration....
Background Modified electroconvulsive therapy (MECT) has been regarded as the most effective antidepressant therapy, despite its cognitive side effects. However, how MECT influences problem-solving capacity in major depressive disorder (MDD), well underlying neurobiological mechanisms, remains unclear. The present study aimed to assess alterations after and explore spontaneous brain activity using amplitudes of low-frequency fluctuations (ALFF)/fractional ALFF. Methods Thirteen...
The rapid growth of Large Language Models (LLMs) has driven the development Vision-Language (LVLMs). challenge hallucination, prevalent in LLMs, also emerges LVLMs. However, most existing efforts mainly focus on object hallucination LVLM, ignoring diverse types LVLM hallucinations. In this study, we delve into Intrinsic Hallucination (IVL-Hallu) issue, thoroughly analyzing different IVL-Hallu their causes and reflections. Specifically, propose several novel tasks categorize them four types:...
Selective serotonin reuptake inhibitors (SSRIs) are widely used drugs for major depressive disorder (MDD), although the treatment outcomes vary in different people. The vesicular glutamate transporter 1 coded by SLC17A7 gene has been reported associated with MDD. According to its role transmission, it is reasonable consider as a potential pharmacogenetic candidate SSRI treatment. A total of 290 MDD patients who had taking SSRIs 6 weeks were recruited. Their genotypes assessed presence 4...
One highly multi-drug-resistant, mucus-producing and foul-smelling strain of Klebsiella ozaenae was isolated from a patient in the ICU Chinese tertiary hospital. MICs several clinical antimicrobials against were obtained using Vitek-2 Compact System with AST-GN13 cards resistance genes evaluated by PCR gene sequencing. The resistant to most β-lactams quinolones tested carried antibiotic genes, including bla(KPC-2), bla(TEM-98), bla(CTX-M-3), bla(SHV-26) qnrS. To our knowledge, this is first...
Abstract Aim A metabolomics approach has recently been used to identify metabolites associated with response antipsychotic treatment. This study was designed the predictive biomarkers of olanzapine monotherapy using a metabolomics‐based strategy. Methods Twenty‐five first‐episode and drug‐naïve female patients schizophrenia were recruited treated for 4 weeks. Psychiatric symptoms assessed Positive Negative Syndrome Scale (PANSS) at baseline 4‐week follow‐up. Results subscore, general...
Multimodal Large Language Models (MLLMs) are known to hallucinate, which limits their practical applications. Recent works have attempted apply Direct Preference Optimization (DPO) enhance the performance of MLLMs, but shown inconsistent improvements in mitigating hallucinations. To address this issue more effectively, we introduce Hallucination-targeted (HDPO) reduce hallucinations MLLMs. Unlike previous approaches, our method tackles from diverse forms and causes. Specifically, develop...
To assess the association of TPH2 gene polymorphisms with response or remission to selective serotonin reuptake inhibitors (SSRIs) drugs during treatment major depressive disorder.For 304 patients receiving SSRIs for depression disorder, 3 single nucleotide (SNPs) (rs1007023, rs1023990 and rs4570625) in were genotyped by MALDI-TOF mass spectrometry using a MassArray Analyzer 4 system. HAMD-17 was adopted as primary rating tool evaluate severity on baseline at end 1st, 2nd, 4th 6th week...