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Contact & Profiles
A5018851156
Research Areas
- interferon and immune responses
- Virus-based gene therapy research
- RNA Interference and Gene Delivery
Soochow University
2022
Second Affiliated Hospital of Soochow University
2022
RNA polymerase mitochondrial (POLRMT) expression and the potential biological functions in skin squamous cell carcinoma (SCC) were explored. We showed that POLRMT is significantly elevated SCC. Genetic depletion of POLRMT, using shRNA-induced knockdown or CRISPR/Cas9-mediated knockout (KO), resulted profound anti-skin SCC activity. In patient-derived primary cells immortalized lines (A431 SCC-9), shRNA KO potently suppressed DNA (mtDNA) transcription viability, proliferation migration....
10.1038/s41420-022-01148-5
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Cell Death Discovery
2022-08-03
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