A5000926416- Neuroinflammation and Neurodegeneration Mechanisms
- Shoulder Injury and Treatment
- Surgical Sutures and Adhesives
- Shoulder and Clavicle Injuries
- Mesenchymal stem cell research
- Osteoarthritis Treatment and Mechanisms
- Sports injuries and prevention
- RNA Research and Splicing
- Inflammasome and immune disorders
- Elbow and Forearm Trauma Treatment
- Wound Healing and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Knee injuries and reconstruction techniques
- Membrane-based Ion Separation Techniques
- Cancer-related molecular mechanisms research
- Membrane Separation Technologies
- Atherosclerosis and Cardiovascular Diseases
- Amino Acid Enzymes and Metabolism
- Proteoglycans and glycosaminoglycans research
- Orthopedic Surgery and Rehabilitation
- Tryptophan and brain disorders
- Hereditary Neurological Disorders
- Neurological Complications and Syndromes
- Endoplasmic Reticulum Stress and Disease
- Solar-Powered Water Purification Methods
Guangxi University of Science and Technology
2019-2025
University Hospital Leipzig
2021-2024
Leipzig University
2022
Third Affiliated Hospital of Sun Yat-sen University
2018-2021
Institute of Remote Sensing and Digital Earth
2021
Sun Yat-sen University
2018-2021
Cognitive impairment is common in extracerebral diseases such as chronic kidney disease (CKD). Kidney transplantation reverses cognitive impairment, indicating that driven by CKD therapeutically amendable. However, we lack mechanistic insights allowing development of targeted therapies. Using a combination mouse models (including mice with neuron-specific IL-1R1 deficiency), single cell analyses (single nuclei RNA sequencing and thallium autometallography), human samples vitro experiments...
Abstract Severe burns are challenging to heal and result in significant death throughout the world. Adipose-derived mesenchymal stem cells (ADSCs) have emerged as a promising treatment for full-thickness burn healing but impeded by their low viability efficiency after grafting vivo. Nitric oxide (NO) is beneficial promoting cell bioactivity, whether it can function effectively vivo still largely unknown. In this study, we bioprinted an efficient biological scaffold loaded with ADSCs NO...
Epilepsy (EP) is a neurological disorder characterized by abnormal, sudden neuronal discharges. Seizures increase extracellular glutamate levels, causing excitotoxic damage. Glutamate transporter type 1 (GLT-1) and its human homologue excitatory amino acid transporter-2 (EAAT2) clear 95% of glutamate. Studies on neurodegenerative diseases suggest that trichostatin A (TSA), broad-spectrum histone deacetylase (HDAC) inhibitor, can GLT-1/EAAT2 transcription. However, the precise mechanism which...
Autograft microskin transplantation has been widely used as a skin graft therapy in full-thickness defect. However, grafting failure can lead to pathological delay wound healing due poor vascularization bed. Considering the active role of adipose-derived stem cell (ADSC) promoting angiogenesis, we intend investigate efficacy autograft combined with ADSC for facilitating defect mouse model.
Abstract Osteosarcoma (OS) is the most common primary solid malignant bone tumor, and its metastasis a prominent cause of high mortality in patients. In this study, prognosis risk signature was constructed based on metastasis‐associated genes. Four microarrays datasets with clinical information were downloaded from Gene Expression Omnibus, 256 genes identified by limma package. Further, protein‐protein interaction network constructed, survival analysis performed using data Therapeutically...
Joint contracture (also known as arthrofibrosis) is a fibrotic joint disorder characterized by excessive collagen production to form scar tissue and adhesions within capsules. This can severely affect day‐to‐day activities quality of life because restricted range motion in affected joints. The precise pathogenic mechanism underlying contractures not fully understood. Lumican belongs the class II small leucine‐rich repeat proteoglycan superfamily, which makes up fibrils extracellular matrix....
Failing to regenerate native tendon tissue in chronic massive rotator cuff tears (CMRCTs) results high retear rates after surgery. Gelatin is a hydrolyzed form of collagen which bioactive and biocompatible. This study intends investigate the suitability integrating gelatin poly (l-lactic acid) (PLLA) fibrous membranes for promoting healing CMRCTs. PLLA/Gelatin electrospun (PGEM) are fabricated using electrospinning technology. The fourier transform infrared, static contact angles tested...
Adipose-derived stem cells (ADSCs) are employed as a promising alternative in treating cartilage injury. Regulating the inflammatory "fingerprint" of ADSCs to improve their anti-inflammatory properties could enhance therapy efficiency. Herein, novel injectable decorin/gellan gum hydrogel combined with encapsulation for arthritis treatment is proposed. Decorin/gellan was prepared according previous manufacturing protocol. The liquid-solid form transition gellan perfectly suitable...
Diabetic kidney disease (DKD) is an emerging pandemic, paralleling the worldwide increase in obesity and diabetes mellitus. DKD now most frequent cause of end-stage renal associated with excessive risk cardiovascular morbidity mortality. a consequence systemic endothelial dysfunction. The endothelial-dependent cytoprotective coagulation protease activated protein C (aPC) ameliorates glomerular damage DKD, part by reducing mitochondrial ROS generation cells. Whether aPC reduces tubular...
Accurate measurement of the minimum distance between bony structures humeral head and acromion or coracoid helps advance a better understanding shoulder anatomical features. Our goal was to precisely determine acromiohumeral (AHD), coracohumeral (CHD), glenohumeral (GHD) in sample Chinese population as an vivo analysis. We retrospectively included 146 patients who underwent supine computed tomography (CT) examination joint. The AHD, CHD, GHD values were quantitatively measured using...
<title>Abstract</title> Cognitive impairment is common in peripheral diseases such as chronic kidney disease (CKD). Kidney transplantation reverses cognitive impairment, indicating that driven by CKD therapeutically amendable. Yet, we lack mechanistic insights allowing targeted therapies. Using a combination of mouse models (including mice with neuron-specific IL-1R1 deficiency), single cell analyses (single nuclei RNA sequencing and thallium automethallography), human samples <italic>in...
Studies addressing the anatomical values of supraspinatus outlet area (SOA) and available (ASOA) are insufficient. This study focused on precisely measuring SOA ASOA in a sample from Chinese population using 3D CT (computed tomography) reconstruction. We analyzed imaging 96 normal patients (59 males 37 females) who underwent shoulder examinations hospital between 2011 2021. The SOA, ASOA, acromiohumeral distance (AHD), coracohumeral (CHD), coracoacromial arch radius (CAR), humeral head (HHR)...
ABSTRACT Background Organ transplantation reverses cognitive impairment in chronic kidney disease (CKD), indicating that driven by CKD is therapeutically amendable. We recently demonstrated impaired cognition linked to interleukin-1β (IL-1β) release from microglia and IL-1 receptor type 1 signalling neuronal cells, thereby identifying a pathway can be exploited therapeutically. However, the mechanism of IL-1β maturation remains unknown. hypothesized cells require caspase-1 for CKD-driven...
Anatomy-based guidelines for shoulder surgery have established the routine preoperative evaluation of humeral head. Despite recognized sex differences in head size, there has been limited investigation into sex-specific variations acromiohumeral contact surface (AHCS) arc length. This study aims to assess AHCS length within a sample Chinese population. We retrospectively analyzed 169 normal CT images from single medical center, collected between 2011 and 2021. The was defined as distance...
Abnormal expression of six-transmembrane epithelial antigen prostate 4 (STEAP4) has been implicated in the carcinogenesis hepatocellular carcinoma (HCC). However, biological role and regulatory mechanisms STEAP4 HCC remain unclear. Here, we analyzed levels differentially expressed genes (DEGs) between high- low-expression groups using multiple databases. Proliferation assays, 5-ethynyl-2'-deoxyuridine (EdU) propidium iodide (PI) flow cytometry, colony formation assays were conducted to...
Based on the analysis of causes corrosion and damage superstructure port T-beam bridge, measures chiseling out damaged concrete at bottom beam removing failed reinforcement in lower layer are taken for most seriously D-level T-beam, so as to achieve ideal repairing effect.However, reduction height will reduce bending capacity while unbonded steel strand body is used external prestressing method can solve safety stability problem long-span during construction period.The with enlarged section...
Joint contracture, resulting from a prolonged joint immobilization, is common complication in orthopedics. Currently, utilizing an internal fixation to restrict knee mobility widely accepted model generate experimental contracture. However, implanting application will inevitably cause surgical trauma the animals. Aiming develop less invasive approach, we combined muscle-gap separation modus with previously reported mini-incision skill during procedure: Two mini skin incisions were made on...
It is controversial whether lifestyle-induced weight loss (LIWL) intervention provides long-term benefit. Here, we investigated the degree of (WL) in a controlled LIWL study determined risk prediabetes and recurrence metabolic syndrome (MetS) during 5-year follow-up. Following LIWL, 58 male participants (age 45−55 years) were divided into four quartiles based on initial WL: Q1 (WL 0−8.1%, n = 15), Q2 8.1−12.8%, 14), Q3 12.8−16.0%, Q4 16.0−27.5%, 15). We analyzed changes BMI, HDL cholesterol,...
Circular RNAs (circRNAs) are a novel class of non-coding RNA that have recently shown to huge capabilities in the regulation gene expression at posttranscriptional level. Growing evidence has indicated circRNAs could serve as competing endogenous (ceRNAs) sponge microRNAs (miRNAs) and suppress functions targeted miRNAs. Osteosarcoma (OS) is most common malignant primary bone cancer. Hsa_circ_0002137 upregulated OS. However, role hsa_circ_0002137 OS remains unclear. Using miRNA pull-down...
<title>Abstract</title> While cognitive impairment is common in peripheral diseases such as chronic kidney disease (CKD), mechanistic insights and effective therapies are lacking<sup>1,2</sup>. Organ substitution reverses impairment, indicating that driven by therapeutically amendable<sup>3,4</sup>. Yet, we lack pharmacological approaches. Here, show despite inflammasome activation the brain protection full body NLRP3-inflammasome deficient mice, microglial caspase-1 deficiency does not...