A5100653590- Meningioma and schwannoma management
- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Head and Neck Surgical Oncology
- Intracranial Aneurysms: Treatment and Complications
- Glioma Diagnosis and Treatment
- Vascular Malformations Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Neurofibromatosis and Schwannoma Cases
- Spinal Fractures and Fixation Techniques
- Oral and Maxillofacial Pathology
- Tissue Engineering and Regenerative Medicine
- Immune cells in cancer
- Cervical and Thoracic Myelopathy
- Adrenal and Paraganglionic Tumors
- Thyroid Cancer Diagnosis and Treatment
- Neurological diseases and metabolism
- Electrospun Nanofibers in Biomedical Applications
- Intracerebral and Subarachnoid Hemorrhage Research
- Cutaneous lymphoproliferative disorders research
- Connective Tissue Growth Factor Research
- Cerebrovascular and Carotid Artery Diseases
- Neurosurgical Procedures and Complications
- Neuroinflammation and Neurodegeneration Mechanisms
- Lymphoma Diagnosis and Treatment
Fudan University
2011-2024
State Key Laboratory of Medical Neurobiology
2022-2024
Third Affiliated Hospital of Sun Yat-sen University
2013-2024
Sun Yat-sen University
2013-2024
Shaanxi Provincial People's Hospital
2017-2024
National Chung Hsing University
2022-2023
Guangdong Medical College
2020
Development Fund
2020
Central South University
2017-2018
Second Affiliated Hospital of Xi'an Jiaotong University
2017
A novel chaetoglobosin named penochalasin I (1) with a unprecedented six-cyclic 6/5/6/5/6/13 fused ring system, and another new J (2), along chaetoglobosins G, F, C, A, E, armochaetoglobosin I, cytoglobosin C (3-9) were isolated from the culture of Penicillium chrysogenum V11. Their structures elucidated by 1D, 2D NMR spectroscopic analysis high resolution mass data. The absolute configuration compounds 1 2 determined comparing theoretical electronic circular dichroism (ECD) calculation...
Abstract Transmembrane protein 106B (TMEM106B), previously identified as a risk factor in frontotemporal lobar degeneration, has recently been detected to form fibrillar aggregates the brains of patients with various neurodegenerative diseases (NDs) and normal elders. While specifics when where TMEM106B fibrils accumulate human brains, well their connection aging disease progression, remain poorly understood. Here, we an antibody (NBP1-91311) that directly binds extracted from brain vitro...
Despite extensive studies on mixed neuropathologies, data from China are limited. This study aims to fill this gap by analyzing brain samples Chinese banks. A total of 1142 brains six banks were examined using standardized methods. Independent pathologists conducted evaluations with stringent quality control. Prevalence and correlations neurological disorders analyzed. Significant proportions displayed primary age-related tauopathy (PART, 35%), limbic-predominant TDP-43 encephalopathy (LATE,...
OBJECT The translamina terminalis corridor was used in the transcranial anterior route to treat third ventricular craniopharyngioma (TVC), which presents a challenge neurosurgeons. endoscopic endonasal approach (EEA) has recently been craniopharyngiomas. However, there are few reports of EEA being TVC. authors' novel surgical treating selected TVC by via suprachiasmatic (STLT) is described. METHODS In this single-center study, STLT resect with great upper and extension causing bulged lamina...
Growth hormone (GH) is known to stimulate luteinizing (LH) release via paracrine interactions between somatotrophs and gonadotrophs. However, it unclear if LH can exert a reciprocal effect modulate somatotroph functions. Here we examined the effects of on GH gene expression using grass carp pituitary cells as cell model. receptors were identified in their activation by human chorionic gonadotropin (hCG) increased ‘steady-state’ mRNA levels. Removal endogenous immunoneutralization antiserum...
CD8+ T cells play an important role in the anti-tumor activities of body. The dysfunction glioma is unclear. This study aims to elucidate cell-derived ADAM10 (A Disintegrin and metalloproteinase domain-containing protein 10) suppression effector by induction regulatory B cells. In this study, were isolated from surgically removed tissue stimulated Phorbol myristate acetage (PMA) culture. levels culture determined enzyme-linked immunosorbent assay. Immune assessed flow cytometry. results...
In adult mammalian brain, vascular cells reside throughout life, close to central nervous system germinal zones, and neural stem (NSCs) mainly localize in the dentate gyrus of hippocampus, subventricular zone, olfactory bulb. Microvessels appear produce a special microenvironment that may influence characteristics NSCs. To explore this potential correlation, an vitro model with cocultured cerebral microvascular endothelial (CMECs) NSCs was established our study by using transwell coculture...
Transsphenoidal approach has been increasingly used in the resection of pituitary adenomas for its minimal invasiveness. However, about 10% these cases, tumor cannot be totally removed due to fibrosis. In this work, object is study relationship between expression transforming growth factor β1 (TGFβ1) and fibrosis adenoma. 38 adenoma specimens were divided into fibrous group (6 cases) non-fibrous (32 cases). TGFβ1 was detected by reverse transcript polymerase chain reaction (RT-PCR)...
The purpose of this study is to examine the clinical outcomes achieved by using initial high-dose intravitreal ganciclovir injections treat cytomegalovirus retinitis in patients without human immunodeficiency virus (HIV) infection. Twenty-four eyes (24 patients) with received multiple weekly intervals. A higher dose (6 mg) was applied at first injection, and a lower used for maintenance. Anterior aqueous humour obtained before each injection. best-corrected visual acuity loads anterior were...
The anterior communicating artery (AComA) complex is the site at which intracranial aneurysms occur most frequently. At present, effective treatments for AComA are yet to be developed. Here, we present our experience in successfully managing via transorbital keyhole approach. A total of 52 patients having a history aneurysm rupture received surgery. All were assigned Hunt-Hess grade prior cistern was opened expose using approach, and then surgically clipped with assistance neuroendoscopy or...
The insulin-like growth factor type 1 receptor (IGF-IR) belongs to the tyrosine kinase (TK) family. Besides being mitogenic, IGF-IR plays a crucial role in cell survival, transformation and maintenance of malignant phenotype. In this study, we cloned cDNA from hypothalamus orange-spotted grouper (Epinephelus coioides) using reverse transcription PCR (RT-PCR) rapid amplification ends (RACE) method. deduced amino acid sequence showed that comprises 1413 residues. It contains cysteine-rich...