A5055001901- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Meningioma and schwannoma management
- Head and Neck Surgical Oncology
- Pituitary Gland Disorders and Treatments
- Tissue Engineering and Regenerative Medicine
- Lymphoma Diagnosis and Treatment
- Reconstructive Facial Surgery Techniques
- Glioma Diagnosis and Treatment
- Vascular Malformations Diagnosis and Treatment
- Cardiac Imaging and Diagnostics
- Electrospun Nanofibers in Biomedical Applications
- Ear Surgery and Otitis Media
- Ear and Head Tumors
- Cerebrospinal fluid and hydrocephalus
- Traumatic Brain Injury and Neurovascular Disturbances
- Histiocytic Disorders and Treatments
- Advanced X-ray and CT Imaging
- Spinal Fractures and Fixation Techniques
- Acute Ischemic Stroke Management
- Viral-associated cancers and disorders
- Vascular Malformations and Hemangiomas
- Chronic Lymphocytic Leukemia Research
- Radiomics and Machine Learning in Medical Imaging
- Nerve injury and regeneration
Tianjin Medical University Eye Hospital
2012-2024
Third Affiliated Hospital of Sun Yat-sen University
2012-2024
Sun Yat-sen University
2012-2024
Tianjin Medical University
2012-2024
Shanghai University of Traditional Chinese Medicine
2023
Shanghai Traditional Chinese Medicine Hospital
2023
Jilin University
2018-2022
Union Hospital
2022
International Peace Maternity & Child Health Hospital
2021
Shanghai Jiao Tong University
2021
Langerhans cell histiocytosis (LCH) is a neoplasm of myeloid origin characterized by clonal proliferation CD1a+/CD207+ dendritic cells. Recurrent BRAF V600E mutation has been reported in LCH. In the present report, we confirm feasibility high-specificity monoclonal antibody VE1 for detecting 36/97 (37.1%) retrospectively enrolled patients with LCH; concordant immunohistochemistry and Sanger sequencing results were seen 94.8% cases. We then assessed tumor immune microenvironment status LCH,...
Abstract Background CD133 is known to be a cancer stem cell (CSC) marker. However, recent studies have revealed that not restricted CSC but expressed only in human normal tissues also some cancers and could serve as prognostic factor for the patients. Nevertheless, expression of cholangiocarcinoma (CC) rare our study detect explore potential functions CC. Methods Fifty-nine cases, comprised 5 liver 54 consecutive CC specimens (21 well-differentiated, 12 moderately-differentiated 21...
Abstract Langerhans cell histiocytosis (LCH) is a proliferative disease of CD1a + /CD207 dendritic cells. Recurrent BRAFV600E and MAP2K1 mutations have been reported in LCH. To investigate the relationship among mutation, clinical findings, differentiation status LCH, respectively, we studied 97 cases LCH by using Sanger sequencing immunohistochemistry. The mutually exclusive mutation rates were 32% 17.5%, respectively. All missense without any in‐frame deletions; 2 new recurrent (ie, p.E38K...
Schwann cells (SCs) are primarily responsible for the formation of myelin sheaths, yet bone marrow mesenchymal stem cell (BMSC)-derived SCs often used to replace autologous and assist with repair peripheral nerve sheaths.In this study, effects two types on remyelination were compared during nerves.Methods: An acellular scaffold was prepared using extraction technique.Rat BMSCs extracted.BMSCs induced differentiate into BMSC-derived (B-dSCs) in vitro.Seed (BMSCs, B-dSCs, SCs) cocultured...
This work aims to explore the effects of adaptive statistical iterative reconstruction (ASiR) and model-based (MBIR) algorithms in reducing computed tomography (CT) radiation dosages abdominal imaging.CT scans on a standard male phantom were performed at different tube currents. Images currents reconstructed with filtered back-projection (FBP), 50% ASiR MBIR compared. The CT value, image noise contrast-to-noise ratios (CNRs) images measured. Volumetric dose indexes (CTDIvol) recorded.At...
CLC-3 chloride channel plays important roles on cell volume regulation, proliferation and migration in normal cancer cells. Recent growing evidence supports a critical role of glioma metastasis, however, the mechanism underlying is unclear. This study finds that upregulated tissues positively correlated with WHO histological grade. Patients high expression had an overall shorter survival time, whereas patients low better time. Silencing endogenous ShCLC-3 adenovirus significantly decreases...
Purpose: To evaluate the visual performance in adolescents undergoing orthokeratology (OrthoK) treatment with two different optical zone diameters (OZDs). Methods: This randomized, double-masked, self-controlled prospective study was conducted at Tianjin Eye Hospital (Tianjin, China) June 2022. Thirty-six eligible schoolchildren were enrolled and fitted corneal refractive therapy lenses sizes of OZDs (5 mm [5OZ] 6 [6OZ]). Each participant randomized to wear 5OZ one eye 6OZ contralateral eye....
Langerhans cell histiocytosis (LCH) is a rare disease characterized by clonal proliferation of CD1a- and CD207 (langerin)-positive dendritic cells. Mutated BRAF (p.V600E) observed in histiocyte-related diseases cell-related diseases, including LCH. BRAFV600E some LCH cases thought to be involved maintaining MAPK activation. We retrospectively analyzed 19 patients diagnosed with In our study, direct sequencing for exon 15, mutation hotspot, demonstrated that 4 out the (21%) harbored GTG > GAG...
Hudson's optimized chemical processing method is the most commonly used to prepare acellular nerve scaffolds for reconstruction of large peripheral defects. However, residual myelin attached basal laminar tube has been observed in prepared using method. Here, we describe a novel producing that eliminates more effectively than through use various detergent combinations sulfobetaine-10, sulfobetaine-16, Triton X-200, sodium deoxycholate, and peracetic acid. In addition, efficacy this new...
miR-126-5p plays an important role in promoting endothelial cell (EC) proliferation. We thus explored whether can promote EC proliferation and angiogenesis chronically ischemic brains (CIBs).Improved revascularization moyamoya patients was correlated with upregulated expression the TM DM. In vitro experiments showed that promoted through PI3K/Akt pathway. CIBs from agomir group exhibited significantly higher p-Akt, VEGF, CD31 eNOS compared control CIBs. The ICBP RCF were better...
Background: The optimal age at which to initiate for auricular reconstruction is controversial. Rib cartilage growth closely related and determines the feasibility outcomes of reconstruction. We developed a method guide timing in children with microtia ranging from 5 10 years. Methods: healthy ear were assessed using low-dose multi-slice computed tomography. lengths eighth rib helix (from helical crus joint earlobe) measured. Surgery was performed when two approximately equal. Results:...
In adult mammalian brain, vascular cells reside throughout life, close to central nervous system germinal zones, and neural stem (NSCs) mainly localize in the dentate gyrus of hippocampus, subventricular zone, olfactory bulb. Microvessels appear produce a special microenvironment that may influence characteristics NSCs. To explore this potential correlation, an vitro model with cocultured cerebral microvascular endothelial (CMECs) NSCs was established our study by using transwell coculture...
Transsphenoidal approach has been increasingly used in the resection of pituitary adenomas for its minimal invasiveness. However, about 10% these cases, tumor cannot be totally removed due to fibrosis. In this work, object is study relationship between expression transforming growth factor β1 (TGFβ1) and fibrosis adenoma. 38 adenoma specimens were divided into fibrous group (6 cases) non-fibrous (32 cases). TGFβ1 was detected by reverse transcript polymerase chain reaction (RT-PCR)...
The mortality and disability rate of patients with ruptured anterior communicating artery (AComA) aneurysm after bleeding is high. Even the most advanced treatment methods, incidence complications remains purpose present study was to determine efficacy microsurgery via supraorbital eyebrow keyhole approach (SOEK) in clipping AComA aneurysms. Between September 2010 October 2018, 543 intracranial aneurysms were admitted Department Neurosurgery Third Affiliated Hospital Sun Yat‑Sen University...