A5102864809- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Fatty Acid Research and Health
- Folate and B Vitamins Research
- Moyamoya disease diagnosis and treatment
- Nerve injury and regeneration
- Glioma Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurological Complications and Syndromes
- Meningioma and schwannoma management
- Parkinson's Disease Mechanisms and Treatments
- Nanoplatforms for cancer theranostics
- Neurological disorders and treatments
- Eicosanoids and Hypertension Pharmacology
- Extracellular vesicles in disease
- Cancer, Hypoxia, and Metabolism
- Spinal Cord Injury Research
- Pituitary Gland Disorders and Treatments
- Energy, Environment, Economic Growth
- Wound Healing and Treatments
- Histone Deacetylase Inhibitors Research
- Advanced Image Processing Techniques
- Neuroblastoma Research and Treatments
- Image and Signal Denoising Methods
Peking University
2024-2025
First Affiliated Hospital of Xiamen University
2021-2025
Third Affiliated Hospital of Sun Yat-sen University
2019-2023
Sun Yat-sen University
2019-2023
Xiamen University of Technology
2023
Xiamen University
2022
Glioblastoma multiforme (GBM) is the most lethal primary brain tumor with a poor median survival of less than 15 months. However, clinical strategies and effective therapies are limited. Here, we found that second-generation small molecule multi-CDK inhibitor AT7519 potential drug for GBM treatment according to high-throughput screening via Approved Drug Library Clinical Compound (2718 compounds). We significantly inhibited cell viability proliferation U87MG, U251, patient-derived cells in...
Abstract Background Endothelial cell (EC)-driven intraneural revascularization (INRV) and Schwann cells-derived exosomes (SCs-Exos) both play crucial roles in peripheral nerve injury (PNI). However, the interplay between them remains unclear. We aimed to elucidate effects underlying mechanisms of SCs-Exos on INRV following PNI. Results found that GW4869 inhibited INRV, as well normoxic (N-SCs-Exos) exhibited significant pro-INRV vivo vitro were potentiated by hypoxic (H-SCs-Exos)....
Due to the non-invasiveness and high precision of electroencephalography (EEG), combination EEG artificial intelligence (AI) is often used for emotion recognition. However, internal differences in data have become an obstacle classification accuracy. To solve this problem, considering labeled from similar nature but different domains, domain adaptation usually provides attractive option. Most existing researches aggregate subjects sessions as a source domain, which ignores assumption that...
OBJECTIVE This study aimed to investigate the effects of bilateral globus pallidus internus (GPi) deep brain stimulation (DBS) on both motor and nonmotor symptoms in patients with Meige syndrome further explore prognostic factors for postoperative outcomes based long-term follow-up results. METHODS The authors retrospectively reviewed medical records a consecutive cohort refractory who underwent GPi-DBS at their center from January 2016 October 2023. Motor function, quality life,...
Background Gender differences are shown to exist in the incidence and outcome of subarachnoid hemorrhage as well formation progression intracranial aneurysms. However, few studies investigated gender difference morphology Methods A total 308 consecutive patients with 346 aneurysms from 2014 2020 were retrospectively analyzed. Differences 10 morphological parameters between males females compared. Continuous variables expressed median [interquartile range (IQR)] analyzed using Mann-Whitney...
At present, the functional recovery after nerve injury is not satisfactory in clinical practice. The aim of this study was to explore molecular mechanism miR-21 promoting Schwann cells (SC) proliferation and axon regeneration peripheral injury, providing a theoretical basis for injured repair. Nerve models were constructed determine expression by Quantitative Real-Time PCR (qRT-PCR). After over-expression SC (mimic-miR-21) group, control (control-miR-21) group blank (RSC96) constructed,...
Traumatic brain injury (TBI) is considered as the most common cause of disability and death, therefore an effective intervention cascade pathology secondary promptly can be a potential therapeutic direction for TBI prognosis. Further study physiological mechanism urgent important. Phosphoglycerate mutase 5 (Pgam5), mitochondrial protein, mediate homeostasis, cellular senescence, necroptosis. This evaluated effects Pgam5 on neurological deficits neuroinflammation controlled cortical...
Background: Mounting experimental evidence supports the concept that RAAS (renin-angiotensin-aldosterone system) is involved in pathogenesis of intracranial aneurysm rupture. However, whether inhibitors could reduce rupture risk aneurysms remains unclear. Methods: We performed a chart review multicenter, prospectively maintained database 3044 hypertensive patients with from 20 medical centers China. The were separated into ruptured and unruptured groups. Univariable multivariable logistical...
Glioblastoma (GBM) patients present poor prognosis. Deubiquitination by deubiquitinating enzymes (DUBs) is a critical process in cancer progression. Ubiquitin-specific proteases (USPs) constitute the largest sub-family of DUBs. Evaluate role USP32 GBM progression and provide potential target for treatment. Clinical significance was investigated using Gene Expression Omnibus databases. Effects on cell growth metastasis were studied vitro vivo. Differentially expressive genes between...
miR-126-5p plays an important role in promoting endothelial cell (EC) proliferation. We thus explored whether can promote EC proliferation and angiogenesis chronically ischemic brains (CIBs).Improved revascularization moyamoya patients was correlated with upregulated expression the TM DM. In vitro experiments showed that promoted through PI3K/Akt pathway. CIBs from agomir group exhibited significantly higher p-Akt, VEGF, CD31 eNOS compared control CIBs. The ICBP RCF were better...
Background and Aims: It has recently emerged the concept of “obesity paradox,” a term used to describe an inverse association between obesity clinical outcomes in cardiovascular diseases stroke. The purpose this study was investigate body mass index (BMI) risk intracranial aneurysm rupture. Methods: In study, we conducted retrospective analysis prospectively maintained database patients with aneurysms from 21 medical centers China. A total 3,965 4,632 saccular were enrolled. Patients...
Objective This study investigates the extent of resection, duration surgery, intraoperative blood loss, and postoperative complications in patients with high-grade glioma who received surgery or without sodium fluorescein guidance. Methods A single-center retrospective cohort was conducted on 112 visited our department underwent between July 2017 June 2022, 61 group 51 non-fluorescein group. Baseline characteristics, duration, resection extent, were documented. Results The significantly...
At present, there is no consensus on the treatment of common carotid artery occlusion (CCAO). We explored surgical indications and observed therapeutic effects carotid-carotid crossover bypass ring-stripping hybrid operation for Rile's type 1A CCAO.The imaging data, clinical manifestations, complications postoperative ischemic events were retrospectively collected from 6 cases with CCAO that underwent surgery in our department 2011 to 2018. Of cases, 4 received 2 operation.Of male females, a...
Basic research on the factors influencing indirect anastomosis formation in a 2-vessel occlusion plus encephalo-myo-synangiosis (2VO + EMS) rat model is conducive to improving efficacy of revascularization surgery clinic. However, time point at which between temporal muscle (TM) and brain naturally has greatest effect after (EMS) remains unknown. Therefore, we conducted this study explore peak 2VO EMS model.Forty rats were randomly divided into five groups (n=8) according length (by week)...
Abstract: The filtered feature selection method has low computational complexity and less time, is widely used in selection, but the only considers importance of features for label classification ignores correlation between features. For this reason, a with improved principal component analysis proposed. main idea that on basis components, loadings each indicator different components their variance contribution ratios are considered. A number indicators largest cumulative rates were...
Abstract Aim Glioblastoma (GBM) has been reported to be the most common high‐grade primary malignant brain tumor in clinical practice and a poor prognosis. O 6 ‐methylguanine‐DNA methyltransferase (MGMT) promoter methylation related prolonged overall survival (OS) GBM patients after temozolomide treatment. Methods Proteomics metabolomics were combined explore dysregulated metabolites possible protein expression alterations white matter (control group), MGMT unmethylated (GBM group) or...