A5109577474- Glioma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Cerebrospinal fluid and hydrocephalus
- Kruppel-like factors research
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Meningioma and schwannoma management
- Circular RNAs in diseases
- Virus-based gene therapy research
- Wnt/β-catenin signaling in development and cancer
- interferon and immune responses
- Cancer-related Molecular Pathways
- Cerebrovascular and Carotid Artery Diseases
- Cancer, Hypoxia, and Metabolism
- Intracerebral and Subarachnoid Hemorrhage Research
- Cancer-related gene regulation
- CAR-T cell therapy research
- Advanced MRI Techniques and Applications
- Neurosurgical Procedures and Complications
- Neonatal and fetal brain pathology
- Vascular Malformations Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging and Analysis
- Computational Drug Discovery Methods
- Facial Nerve Paralysis Treatment and Research
First Affiliated Hospital of Xiamen University
2016-2025
Xiamen Blood Center
2024
Wuhan Polytechnic University
2024
Hubei Academy of Agricultural Sciences
2024
Gansu University of Traditional Chinese Medicine
2024
Xiamen University
2012-2023
Fujian Medical University
2008-2021
First Affiliated Hospital of Fujian Medical University
2020
Fujita Health University Hospital
2020
Changsha University of Science and Technology
2017
Glioblastoma multiforme (GBM) is the most lethal primary brain tumor with a poor median survival of less than 15 months. However, clinical strategies and effective therapies are limited. Here, we found that second-generation small molecule multi-CDK inhibitor AT7519 potential drug for GBM treatment according to high-throughput screening via Approved Drug Library Clinical Compound (2718 compounds). We significantly inhibited cell viability proliferation U87MG, U251, patient-derived cells in...
Magnetic nano-size solid acid catalysts were prepared, characterized, and examined, for the first time, esterification of free fatty (FFA) to develop a green efficient pretreatment step producing biodiesel (fatty methyl ester, FAME) from waste grease containing FFA. PGMA-cat 4, consisting core iron oxide magnetic nanoparticles (MNPs), poly(glycidyl methacrylate) (PGMA) shell, sulfonic groups on surface, was synthesized in 98% yield corresponding core–shell structured PGMA–MNPs epoxy surface...
Accumulating evidence in the last decade has pointed to effectiveness of oncolytic virus treatment a variety cancer types preclinical or clinical studies, showing high potency and low toxicity compared conventional treatments. To track this research trend highlight future directions, we conducted bibliometric analysis date.Relevant studies were obtained from Web Science Core Collection between January 2000 December 2018. Data collected terms number publications, country, journal publication,...
OBJECTIVE This study aimed to investigate the effects of bilateral globus pallidus internus (GPi) deep brain stimulation (DBS) on both motor and nonmotor symptoms in patients with Meige syndrome further explore prognostic factors for postoperative outcomes based long-term follow-up results. METHODS The authors retrospectively reviewed medical records a consecutive cohort refractory who underwent GPi-DBS at their center from January 2016 October 2023. Motor function, quality life,...
Accurate identification of the type seizure is very important for treatment plan and drug prescription epileptic patients. Artificial intelligence has shown considerable potential in fields automated EEG analysis classification. However, highly personalized representation seizures led to many research results that are not satisfactory clinical applications. In order improve adaptability algorithm, this paper proposes an adversarial learning-driven domain-invariant deep feature method, which...
Abstract Background Although chronic periodontitis has previously been reported to be linked with Alzheimer's disease (AD), the pathogenesis between two is unclear. The purpose of this study analyze and screen relevant promising molecular markers (AD). Methods In paper, we analyzed three AD expression datasets extracted differentially expressed genes (DEGs), then intersected them obtained from text mining, finally integrated DEGs. We followed that by enriching matching cell signal cascade...
Reactive gliosis had been implicated in injury and recovery patterns associated with hydrocephalus. Our aim is to determine the efficacy of minocycline, an antibiotic known for its anti-inflammatory properties, reduce reactive inhibit development hydrocephalus.The ventricular dilatation were evaluated by MRI at 1-week post drugs treated, while GFAP Iba-1were detected RT-PCR, Immunohistochemistry Western blot. The expression Iba-1 was significantly higher hydrocephalic group compared saline...
Glioblastoma (GBM) patients present poor prognosis. Deubiquitination by deubiquitinating enzymes (DUBs) is a critical process in cancer progression. Ubiquitin-specific proteases (USPs) constitute the largest sub-family of DUBs. Evaluate role USP32 GBM progression and provide potential target for treatment. Clinical significance was investigated using Gene Expression Omnibus databases. Effects on cell growth metastasis were studied vitro vivo. Differentially expressive genes between...
Abstract Background The circular RNA (circRNA) plays a vital role in the pathogenesis of tumors as competitive endogenous (ceRNA). Given high aggressiveness and fatality rate glioblastoma (GBM) well poor prognosis, it is necessary to construct circRNA-related ceRNA network for further studies on mechanism GBM identify possible biomarkers therapeutic drugs. Methods Three datasets from gene expression omnibus (GEO) database were downloaded distinguish differential circRNAs, microRNAs,...
Oncolytic viruses represent a promising therapeutic modality, but they have yet to live up their potential. Safety and efficacy concerns impel us identify least toxic oncolytic agents that would generate durable multifaceted anti-tumor immune responses disrupt the tumors. Here we describe rational engineered herpes virus (OVH) is selective killer for targeting tumors, has strong safety records, induces complete regression of tumors in multiple tumor models, elicits potent antitumor immunity....
The myofibrillar protein (MP) of duck meat is prone to excessive oxidation during thermal processing, resulting in a decline its overall quality. In this paper, the effect shikimic acid on oxidative structure muscle fibrin was studied. findings showed that, at mass ratio 1:50,000 (g/g) between and MP, carbonyl content MP reduced by 74.20%, while sulfhydryl increased 73.56%. demonstrated highest denaturation temperature, whereas absorption lowest. percentage α-helixes β-sheets 16.72% 24.74%,...
Abstract Heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 is involved in the synthesis of RNA. Its expression up‐regulated many tumor cell lines. In this study, we investigated distribution hnRNP matrix, including its co‐localization with products related genes. Results from 2‐DE PAGE and MS showed that components matrix proteins SK‐N‐SH cells, level down‐regulated after retinoic acid (RA) treatment. Protein immunoblotting results further confirm existence as well down‐regulation RA...
Background Considering the high invasiveness and mortality of glioma as well unclear key genes signaling pathways involved in development gliomas, there is a strong need to find potential gene biomarkers available drugs. Methods Eight samples twelve control were analyzed on GSE31095 datasets, differentially expressed (DEGs) obtained via R software. The related further acquired from text mining. Additionally, Venny program was used screen out common two sets DAVID analysis conduct...
Background: Although the tumor microenvironment (TME) is known to influence prognosis of glioblastoma (GBM), underlying mechanisms are not clear. This study aims identify hub genes in TME that affect GBM. Methods: The transcriptome profiles central nervous systems GBM patients were downloaded from Cancer Genome Atlas (TCGA). ESTIMATE scoring algorithm was used calculate immune and stromal scores. application these scores histology classification tested. Univariate Cox regression analysis...