A5100452046- Genetic Mapping and Diversity in Plants and Animals
- Cell Adhesion Molecules Research
- Rice Cultivation and Yield Improvement
- Molecular Biology Techniques and Applications
- GABA and Rice Research
- Plant Disease Resistance and Genetics
- Monoclonal and Polyclonal Antibodies Research
- Hepatitis B Virus Studies
- Cellular Mechanics and Interactions
- RNA Research and Splicing
- Immunotherapy and Immune Responses
- Neuroscience and Neuropharmacology Research
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Parvovirus B19 Infection Studies
- MicroRNA in disease regulation
- Hepatitis C virus research
- Cytokine Signaling Pathways and Interactions
- Protease and Inhibitor Mechanisms
- Cancer Mechanisms and Therapy
- Galectins and Cancer Biology
- Nuclear physics research studies
- Ubiquitin and proteasome pathways
- Oral and Maxillofacial Pathology
- HIV/AIDS drug development and treatment
Emory University
2024
Education Department of Heilongjiang Province
2024
Biotechnology Research Institute
2021-2024
Air Force Medical University
2013-2023
Tianjin Medical University
2023
Tianjin Medical University Eye Hospital
2023
Xi'an Medical University
2023
Xinjiang Medical University
2022
State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation
2022
Modular Genetics (United States)
2022
Background A better understanding of the molecular mechanisms that manifest in immunosuppressive tumor microenvironment (TME) is crucial for developing more efficacious immunotherapies hepatocellular carcinoma (HCC), which has a poor response to current immunotherapies. Regulatory T (Treg) cells are key mediators HCC-associated immunosuppression. We investigated selective mechanism exploited by HCC lead Treg expansion and find Methods used matched tissues blood samples from 150 patients with...
The mass table in the deformed relativistic Hartree-Bogoliubov theory continuum (DRHBc) with PC-PK1 density functional has been established for even-$Z$ nuclei $8\le Z\le120$, extended from previous work even-even [Zhang $\it{et.~al.}$ (DRHBc Mass Table Collaboration), At. Data Nucl. Tables 144, 101488 (2022)]. calculated binding energies, two-nucleon and one-neutron separation root-mean-square (rms) radii of neutron, proton, matter, charge distributions, quadrupole deformations, neutron...
Abstract The main etiopathogenesis of rheumatoid arthritis (RA) is overexpressed inflammatory cytokines and tissue injury mediated by persistent NF-κB activation. MicroRNAs widely participate in the regulation target gene expression play important roles various diseases. Here, we explored mechanisms microRNAs RA. We found that microRNA (miR)-10a was downregulated fibroblast-like synoviocytes (FLSs) RA patients compared with osteoarthritis (OA) controls this downregulation could be triggered...
Abstract Tamoxifen remains the most effective treatment for estrogen receptor α (ERα)‐positive breast cancer. However, many patients still develop resistance to tamoxifen in association with metastatic recurrence, which presents a tremendous clinical challenge. To better understand from perspective of tumor microenvironment, whole microenvironment landscape is charted by single‐cell RNA sequencing and new cancer‐associated fibroblast (CAF) subset, CD63 + CAFs, identified that promotes...
Abstract A wide range of genes involved in breast cancer metastasis have been reported to be related the microenvironment. We studied role discoidin domain receptor 2 ( DDR2 ), a collagen‐binding receptor, progression under hypoxic conditions. showed that protein expression closely correlated with marker HIF ‐1α clinical specimens. The vitro data demonstrated hypoxia treatment increased levels both and phosphorylation human cell lines. In vivo , orthotopic tumour xenografts knockdown...
Forkhead box protein 3 (FOXP3) plays an important role in breast cancer as X-linked tumor suppressor gene. However, the biological functions and significance of FOXP3 metastasis remain unclear. Here, we find that, clinically, nuclear expression is inversely correlated with metastasis. Moreover, demonstrate that significantly inhibits adhesion, invasion cells vivo vitro. In addition, adhesion molecule CD44 found to be suppressed by through transcriptome sequence analysis (RNA-seq). A...
Purpose: Glioblastoma is the most common and aggressive type of primary brain malignancy associated with a poor prognosis. Previously, we found that phosphatase regenerating liver-3 (PRL-3) was significantly up-regulated in glioblastoma as determined by microarray analysis. However, function PRL-3 remains unknown. We aimed to investigate clinical relationship between glioblastoma, uncover mechanisms process glioblastoma. Methods: expression evaluated 61 samples 4 cell lines RT-qPCR...
Regulation of matrix metalloproteinases (MMPs) by collagen in the fibroblast-like synoviocytes (FLSs) plays a critical role joint destruction rheumatoid arthritis (RA). Our previous study indicated that discoidin receptor 2 (DDR2) mediated upregulation MMPs. However, precise underlying mechanism remains unclear. We report here CYR61, secreted, extracellular matrix-associated signaling protein which is capable regulating broad range cellular activities, including cell adhesion, migration,...
Abstract Malignant melanoma involving the respiratory tract is nearly always metastatic in origin, and primary tumors are very rare. To our knowledge, about 30 cases have been reported English literature, one of which involved multiple brain metastases. Here, we report two pulmonary malignant melanoma. The first case, occurred a 52-year-old Chinese female patient who died 4 months after initial diagnosis, rapid intrapulmonary intracranial second patient, 65-year-old female, underwent...
Objective This study was undertaken to uncover the pathophysiologic role of discoidin domain receptor 2 (DDR‐2), a putative fibrillar collagen receptor, in inflammation promotion and joint destruction rheumatoid arthritis (RA). Methods In synovial tissue from patients with RA mice antibody–induced (CAIA) (using Ddr2 −/− DBA/1 mice), gene protein expression levels DDR‐2, interleukin‐15 (IL‐15), Dkk‐1 were measured by quantitative reverse transcription–polymerase chain reaction, Western...
Abstract FOXP3 is an important X-linked suppressor of breast cancer. It reported that usually mutant, absent, or cytoplasmic distribution in cancer cells, which increases the risk However, our study full-length transcript can be detected cells and nuclear expressed some samples. Therefore, question how tumor-suppressive function wild-type negated these cancers. We found Gal-1 a novel interacting protein Furthermore, results show FKH domain essential for its interaction with Gal-1. Through...
Colon cancer stem cell (cCSC) is considered as the seed of colon initiation and metastasis. Cyclooxygenase-2 (COX2), a downstream target NFκB, found to be essential in promoting renewal. However, how COX2 dysregulated cCSCs largely unknown. In this study, we that expression transcription factor FOXP3 was much lower spheroids than parental tumor cells. Overexpression significantly decreased numbers spheres, reduced side population. Accordingly, size weight xenograft model. The inhibitory...
Oilseed-vegetable-dual-purpose (OVDP) rapeseed can effectively alleviate the land contradiction between crops and it supplements vegetable supplies in winter or spring. The soluble solids content (SSC) is an important index that used to evaluate quality sugar of fruits vegetables. However, genetic architecture underlying SSC Brassica napus shoots still unclear. Here, quantitative trait loci (QTLs) for B. were investigated by performing linkage mapping using a recombinant inbred line...
Tumor targeting agents are being developed for early tumor detection and therapeutics. We previously identified the peptide SNFYMPL (SNF*) demonstrated its specific binding to human esophageal specimens of high-grade dysplasia (HGD) adenocarcinoma with imaging ex vivo. Here, we aim identify target this investigate potential applications in drug delivery. With SNF* conjugated affinity chromatography, mass spectrum, Western blot, enzyme-linked immunosorbent assay (ELISA), molecular docking,...
Abstract We examined whether lamivudine treatment, in addition to the rapid decline of HBV serum DNA described a large number laboratories, causes changes composition and amount discernable circulating viral RNA. Nucleic acids were extracted from serial samples patient infected chronically treated with for 14 weeks. Three sequence segments genome synthesized successively during replication, X, C, X‐preC, analyzed by competitive PCR RT/PCR. In addition, RNA was differential polyadenylation....
Glypican-3 (GPC3) has been reported to be a novel serum and histochemical marker for HCC. The positivity or negativity GPC3 in hepatic precancerous lesions, such as dysplastic nodules (DN), also described. Moreover, our previous studies have demonstrated that some DN liver cirrhosis represent monoclonal hyperplasia, confirmed their neoplastic nature. However, additional must performed investigate further the relationship between with Thus, we first investigated expression of 136 HCC 103...
Botryosphaeria dothidea causes diseases in many different hosts worldwide. This species has become the most prominent fungal taxon causing grapevine trunk disease China, with a recent outbreak. To reveal genetic diversity and explore origin of B. dothidea, six novel microsatellite markers were developed used for genotyping 151 isolates obtained from China overseas. The results demonstrated high populations. Bayesian cluster analysis separated total into five Chinese grapevines observed to...