A5016835638- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Acute Myeloid Leukemia Research
- CNS Lymphoma Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- Neutropenia and Cancer Infections
- Viral-associated cancers and disorders
- Chronic Lymphocytic Leukemia Research
- COVID-19 Clinical Research Studies
- Cutaneous lymphoproliferative disorders research
- Multiple Myeloma Research and Treatments
- Chronic Myeloid Leukemia Treatments
- Antifungal resistance and susceptibility
- Cancer Immunotherapy and Biomarkers
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Reliability and Agreement in Measurement
- Acute Lymphoblastic Leukemia research
- Vascular Tumors and Angiosarcomas
- COVID-19 Impact on Reproduction
- Health Education and Validation
- SARS-CoV-2 and COVID-19 Research
- Monoclonal and Polyclonal Antibodies Research
- Blood disorders and treatments
- Autoimmune and Inflammatory Disorders Research
Istanbul Medipol University
2015-2025
Istanbul University
2019-2022
Palmetto Hematology Oncology
2019
Istanbul Memorial Hospital
2011
Istanbul Florence Nightingale Hospital
2009
Akdeniz University
2004
Glofitamab is a CD3xCD20 bi-specific antibody with two fragments directed to the CD20 antigen and single CD3-binding fragment. Encouraging response survival rates were recently reported in pivotal phase II expansion trial conducted patients relapsed/refractory (R/R) B-cell lymphoma. However, real-world data of all ages no strict selection criteria are still lacking. Herein, this retrospective study aimed evaluate outcomes diffuse large lymphoma (DLBCL) who received glofitamab via...
Background/aim: Primary antifungal prophylaxis (AFP) is recommended by guidelines as the gold standard for patients with hematologic malignancies. This study aimed to investigate level of knowledge and translation guideline recommendations into real-life setting among physicians in Türkiye.Materials methods: In this prospective, observational study, physicians' ΑFP acute myeloid leukaemia (AML) or myelodysplastic syndrome (MDS) undergoing first remission-induction (Group I),...
Abstract Myelodysplastic syndrome (MDS) represents a heterogeneous group of potentially malignant diseases bone‐marrow stem cells. Acute myelogenous leukaemia (AML) is an inevitable outcome for many patients with MDS. Azacitidine has been reported to result in comparably higher response rates and improved survival than other treatment strategies. In this retrospective study, we report the results on 25 ‘real life’ MDS, CMML or AML treated azacitidine between 2005 2009. All fulfilled World...
Patients with solid malignancies are more vulnerable to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection than the healthy population. The outcome of SARS-CoV-2 in highly immunosuppressed populations, such as patients hematological malignancies, is a point interest. We aimed analyze symptoms, complications, intensive care unit admissions, and mortality rates infected Turkey.In this multicenter study, we included 340 adult pediatric diagnosed from March November 2020....
Objectives: Accurate, reliable laboratory reference ranges are essential for effective clinical evaluation and monitoring. We present robust established hematology parameters using the Sysmex XT2000i analyzer. Methods: Blood samples were taken from 17409 healthy adults (19 to 49 years, 51.4% men 48.6% women) routine analysis performed. Patients assessed as on basis of a medical history examinations. Serum hematinic assays (vitamin B12, folate, iron ferritin) also analyzed in order exclude...
Sarcoidosis is a granulomatous disease that mostly involves the lungs. Its association with malignancies has been well documented. Several mechanisms have proposed may underlie this concurrence including triggering tumour antigens and defective cellular immunity.We briefly review literature on malignancy associated sarcoidosis report two female lymphoma patients of 49 56 years age who, during their course disease, developed was misinterpreted as relapse positron emission tomography-computed...
In chronic myeloid leukemia (CML), the occurrence of blastic transformation is rare. Treatment outcome generally poor. Allogeneic stem cell transplantation (allo-SCT) only potentially curative treatment option for advanced-phase CML. Infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates are associated with high morbidity and mortality rates, particularly in patients haematological malignancies. Infection colonization these multiresistant bacteria may represent a...
Chimeric antigen receptor T (CAR-T) cell therapies have already made an impact on the treatment of B-cell malignancies. Although CAR-T are promising, there concerns about commercial products regarding their affordability and sustainability. In this preliminary study, results first production clinical data academic (ISIKOK-19) trial in Turkey presented.A pilot (NCT04206943) designed to assess safety feasibility ISIKOK-19 T-cell therapy for patients with relapsed refractory CD19+ tumors was...
Background/aim: A SARS-Cov2 infection which was first arised from Wuhan in December 2019 and named as COVID-19. Still there lacks either a specific treatment or vaccine to treat Convalescent plasma (CP) previously used successfully SARS-CoV-1 MERS infections. Health authority Turkey has published guideline integrate this promising option the process of patients who are prone high risk developing severe COVID 19. Materials Methods: Forty consecutive had received CP at our center were included...
Evans syndrome (ES) is a rare hematological disease characterized by autoimmune hemolytic anemia, immune thrombocytopenia, and/or neutropenia, all of which may be seen simultaneously or subsequently. Thrombotic events in ES are uncommon. Furthermore, non-ST segment-elevation myocardial infarction (NSTEMI) during very condition. Here, we describe case 69-year-old female patient presenting with NSTEMI and ES. Revascularization via percutaneous coronary intervention (PCI) was scheduled...
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative treatment option for patients with acute lymphoblastic leukemia (ALL). The potential of allo-HSCT ALL is, in part, due to the graft‑vs.‑leukemia (GVL) effect, addition intensive conditioning chemo‑radiotherapy. However, relapse remains major cause failure following allo‑HSCT ALL. In setting, testing genetic markers chimerism has become part routine diagnostic program. Routine analysis usually performed...