Yu Wu

ORCID: 0000-0002-3435-1074
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About
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Research Areas
  • Esophageal Cancer Research and Treatment
  • Mesenchymal stem cell research
  • Colorectal Cancer Screening and Detection
  • Osteoarthritis Treatment and Mechanisms
  • Ultrasound and Hyperthermia Applications
  • Surgical Sutures and Adhesives
  • Ferroptosis and cancer prognosis
  • Multiple and Secondary Primary Cancers
  • Wound Healing and Treatments
  • Esophageal and GI Pathology
  • Silk-based biomaterials and applications
  • Shoulder Injury and Treatment
  • Seaweed-derived Bioactive Compounds
  • Electrospun Nanofibers in Biomedical Applications
  • Nerve injury and regeneration
  • Healthcare and Venom Research
  • Helicobacter pylori-related gastroenterology studies
  • Echinoderm biology and ecology
  • Planarian Biology and Electrostimulation
  • Ultrasound Imaging and Elastography
  • Photoacoustic and Ultrasonic Imaging
  • Wireless Body Area Networks
  • Wnt/β-catenin signaling in development and cancer
  • Genomics, phytochemicals, and oxidative stress
  • Invertebrate Immune Response Mechanisms

Jiangnan University
2024-2025

Wenzhou University
2024

Institute of Remote Sensing and Digital Earth
2021

Third Affiliated Hospital of Sun Yat-sen University
2021

Sun Yat-sen University
2021

Tianjin Medical University General Hospital
2018-2020

Shaanxi Provincial People's Hospital
2019

Shanxi Medical University
2019

Sichuan Cancer Hospital
2011

Summary Stem cell transplantation, especially treatment with bone marrow mesenchymal stem cells (BMSCs), has been considered a promising therapy for the locomotor and neurological recovery of spinal cord injury (SCI) patients. However, clinical benefits BMSCs transplantation remain limited because considerably low viability inhibitory microenvironment. In our research, low‐intensity pulsed ultrasound (LIPUS), which widely applied to applications fundamental was employed improve properties...

10.1111/cns.13071 article EN CNS Neuroscience & Therapeutics 2018-10-08

Abstract Severe burns are challenging to heal and result in significant death throughout the world. Adipose-derived mesenchymal stem cells (ADSCs) have emerged as a promising treatment for full-thickness burn healing but impeded by their low viability efficiency after grafting vivo. Nitric oxide (NO) is beneficial promoting cell bioactivity, whether it can function effectively vivo still largely unknown. In this study, we bioprinted an efficient biological scaffold loaded with ADSCs NO...

10.1093/rb/rbab014 article EN cc-by Regenerative Biomaterials 2021-04-25

New cases and deaths of gastrointestinal cancers are predicted to increase significantly by 2040. This study aims explore cross-country inequalities trends in global burdens colon rectum cancer (CRC), esophageal (EC) gastric (GC). Data from the Global Burden Diseases Study 2019 were analyzed examine disability-adjusted life-years (DALYs) for three with estimated annual percentage change (EAPC) Joinpoint analysis. Inequality their DALYs rates was assessed slope index inequality concentration...

10.1007/s12672-025-01762-6 article EN cc-by-nc-nd Discover Oncology 2025-01-13

Background Neuraminidase-1 (NEU1) is an enzyme that breaks down sialic acids on glycoproteins and glycolipids. Aberrant expression of NEU1 has been linked to the progression numerous malignancies, including liver cancer. Oseltamivir phosphate (OP) a drug used treat prevent influenza, which specifically inhibits NEU1. However, molecular mechanisms in cancer potential therapeutic effects OP remain largely unclear. Methods was evaluated using public databases validated our samples. CRISPR/Cas9,...

10.3389/fphar.2025.1556661 article EN cc-by Frontiers in Pharmacology 2025-03-24

The therapeutic potential of fucoidan (FUC), a natural polysaccharide, in metabolic disorders is recognized, yet its underlying mechanisms remain unclear. We conducted investigations into the FUC sourced from Sargassum fulvellum concerning induced by high-sucrose diet (HSD), employing Drosophila melanogaster and mice models. larvae were subjected to HSD exposure monitor growth inhibition, reduced pupation, developmental delays. Additionally, we examined impact on growth- development-related...

10.1016/j.jare.2024.05.034 article EN cc-by-nc-nd Journal of Advanced Research 2024-05-01

Failing to regenerate native tendon tissue in chronic massive rotator cuff tears (CMRCTs) results high retear rates after surgery. Gelatin is a hydrolyzed form of collagen which bioactive and biocompatible. This study intends investigate the suitability integrating gelatin poly (l-lactic acid) (PLLA) fibrous membranes for promoting healing CMRCTs. PLLA/Gelatin electrospun (PGEM) are fabricated using electrospinning technology. The fourier transform infrared, static contact angles tested...

10.1002/mabi.202100281 article EN Macromolecular Bioscience 2021-10-28

To investigate how a back propagation neural network based on genetic algorithm (GA-BPNN) optimizes the low-intensity pulsed ultrasound (LIPUS) stimulation parameters to improve bone marrow mesenchymal stem cells (BMSCs) viability further. The LIPUS were set at various frequencies (0.6, 0.8, 1.0, and 1.2 MHz), voltages (5, 6, 7, 8 V), durations (3, 9 minutes). As only some discrete points can be up in experiments, optimal parameter may not value of these settings. GA-BPNN is used optimize...

10.1155/2019/8386024 article EN cc-by Computational and Mathematical Methods in Medicine 2019-10-01

<title>Abstract</title> Purpose To explore cross-country inequalities in global disease burdens of colon and rectum cancer (CRC), esophageal (EC) gastric (GC). Methods Data from the Global Burden Diseases Study 2019 were analyzed to examine trends disability-adjusted life-years (DALYs) for three cancers using Estimated Annual Percentage Change (EAPC) Joinpoint analysis. Inequality DALYs rates was assessed with Slope Index Concentration Index, based on Socio-Demographic (SDI). Results From...

10.21203/rs.3.rs-4826804/v1 preprint EN cc-by Research Square (Research Square) 2024-08-30

In the present study, we have demonstrated that alginate and collagen sponge can act as scaffolds in order to support 3-dimensional structure for differentiated bone marrow derived mesenchymal stem cells (BMSCs) during chondrogenesis vitro vivo. The chondrogenic induced BMSCs were well distributed differentiation system before implantation, then they produced sufficient ECM implants form chondroid aggregates our opinion, well-differentiated is a crucial feature of cartilage repair only be...

10.4028/www.scientific.net/kem.474-476.1935 article EN Key engineering materials 2011-04-01
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