A5100769375- Bone Tissue Engineering Materials
- Mesenchymal stem cell research
- Orthopaedic implants and arthroplasty
- Dental Implant Techniques and Outcomes
- Cancer-related molecular mechanisms research
- ICT Impact and Policies
- Periodontal Regeneration and Treatments
- Aquaculture disease management and microbiota
- Virology and Viral Diseases
- Mosquito-borne diseases and control
- Orthopedic Infections and Treatments
- Cellular Mechanics and Interactions
- MicroRNA in disease regulation
- Silk-based biomaterials and applications
- Tissue Engineering and Regenerative Medicine
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Extracellular vesicles in disease
- Facial Trauma and Fracture Management
- Assembly Line Balancing Optimization
- Liver Disease Diagnosis and Treatment
- Tendon Structure and Treatment
- Autophagy in Disease and Therapy
- Ocular Surface and Contact Lens
- Planarian Biology and Electrostimulation
- Effects of Radiation Exposure
Shenzhen Academy of Inspection and Quarantine
2025
Sichuan University
2008-2022
West China Medical Center of Sichuan University
2007-2020
Xinjiang Medical University
2018
Air Force Medical University
2012-2015
Changhong (China)
2014
Hiroshima University
2013
First Affiliated Hospital of Soochow University
2011
Soochow University
2011
KTH Royal Institute of Technology
2003
ABSTRACT Although anti‐angiogenic therapies (AATs) have some effects against multiple malignancies, they are limited by subsequent tumor vasculogenesis and progression. To investigate the mechanisms which progression following AATs, we transfected microRNA (miR)‐9 into human umbilical vein endothelial cells (HUVECs) to mimic tumor‐associated in hepatocellular carcinoma simulated AATs vitro vivo. We found that administration of angiogenesis inhibitor vandetanib completely abolished...
Corneal integrity, transparency and vision acuity are maintained by corneal epithelial cells (CECs), which continuously renewed limbal stem (LSCs). Deficiency of CECs and/or LSCs is associated with numerous ocular diseases. Paired box (PAX)6 an eye development-associated transcription factor that necessary for cell fate determination differentiation CECs. In the present study, PAX6 gene was introduced into adipose-derived rat mesenchymal (ADMSCs) to investigate whether PAX6-transfected were...
Abstract: Titanium implants have been widely used for many medical applications, but bacterial infection after implant surgery remains one of the most common and intractable complications. To this end, long-term antibacterial ability surface is highly desirable to prevent implant-associated infection. In study, a novel coating containing new agent, (Z-)-4-bromo-5-(bromomethylene)-2(5H)-furanone loaded poly(L-lactic acid) nanoparticles, was fabricated on microarc-oxidized titanium purpose....
Dental implants have become increasingly common for the management of missing teeth. However, peri-implant infection remains a problem, is usually difficult to treat, and may lead eventually dental implant failure. The aim this study was fabricate novel antibacterial coating containing halogenated furanone compound, ie, (Z-)-4-bromo-5-(bromomethylene)-2(5H)-furanone (BBF)-loaded poly(L-lactic acid) (PLLA) nanoparticles on microarc-oxidized titanium evaluate its release behavior in...
Shear stress is thought to be important in maintaining vascular homeostasis and regulating remodeling. The authors have previously shown that low shear increases interleukin (IL)-8 gene expression endothelial cells. However, the detailed events contribute regulation of this remain identified. In study, examined whether stress-induced IL-8 mRNA cells mechanotransduced by integrins cytoskeleton. Exposure (4.2 dyne/cm(2)) rapidly increased mRNA. induced was inhibited GRGDNP, which blocked...
Pulsed electromagnetic field (PEMF) is a non-invasive physical therapy used in the treatment of fracture nonunion or delayed healing. PEMF can facilitate osteogenic differentiation bone marrow mesenchymal stem cells vitro. Amniotic epithelial (AECs) have been proposed as potential source for cell therapy. However, whether could modulate AECs unknown. In present study, effects on were investigated. isolated from amniotic membrane human placenta by trypsin digestion and induced and/or...
Studying the feasibility and viability of various future infrastructure architectures potential road-maps their deployment is focus 4th Generation Wireless Infrastructures (4GW) project within strategic Personal Computing Communication (PCC) program (Molin 1998). In attempting to realize PCC vision "mobile multimedia all at today's prices for fixed telephony", a difficult problem arises. contrast process solving engineering business problems in current or imminent wireless systems, where...
Much attention has been paid to the modification of a titanium surface with an alkylphosphonic acid (PA)-based self-assembled monolayer (SAM) accelerate hydroxyapatite (HA) deposition on surface. In order further rate HA deposition, we examined here effect alkyl chain length SAMs formation layer. PAs three different lengths (3, 6, and 16 methylene units) were used for preparation SAM titanium. The specimens monolayers soaked in simulated body fluid under physiological conditions 4 weeks....
Emerging evidence suggests that both apoptosis and autophagy contribute to global cerebral ischemia‑reperfusion (GCIR)‑induced neuronal death, which results from cardiac arrest (CA). However, the mechanism of how GCIR may affect balance between resulting CA remains be elucidated. Additionally, role adiponectin (APN) in reversing induced by following arrest‑cardiopulmonary resuscitation (CA‑CPR) is unclear. Thus, aim present study was investigate response clarify whether APN alter death...
Mesenchymal stem cells (MSCs) have been used for the treatment of various human diseases. To better understand mechanism this action and fate these cells, magnetic resonance imaging (MRI) has tracking transplanted cells. Prussian blue nanoparticles (PBNPs) demonstrated to ability labeling visualize them as an effective MRI contrast agent. In study, we aimed investigate efficiency biological effects labeled MSCs using PBNPs. We first synthesized characterized Then, iCELLigence real-time cell...
A novel hydroxyapatite-wollastonite/silk fibroin (AW/SF) composite was prepared for bone repair and replacement by a modified coprecipitation method. The wollastonite powders introduced in the were sintered with full crytallinity ground to diameter of 30–50 nm. FT-IR XRD analyses showed that silk fibroin, wollastonite, hydroxyapatite co-existed composite, but newly formed had low crystallinity ascribing temperature procedure. exhibited both higher compressive strength (84.4 MPa) Barcol...
We co-modified rat mesenchymal stem cells (rMSCs) with bone morphogenetic protein-2 (BMP-2) and basic fibroblast growth factor (bFGF) genes, then evaluated their osteogenic activity in vitro ectopic formation vivo.Nude mice (male, 20±2 g) were randomly divided into 2 groups: a control group (n=30) transfection (n=30). In the group, rMSCs+scaffold was implanted intramuscular pocket left femur, BMP-2 gene modified right femur. bFGF BMP-2+bFGF Under anesthesia, an 8-mm incision made over...
Aseptic loosening induced by wear debris particles of artificial joint is characterized a considerable suppression osteogenesis. The objective this investigation was to determine the effect different-sized titanium particle on protein synthesis, and mineralization in bone marrow–derived mesenchymal stem cells(BMSCs) toward osteogenic differentiation vitro. Rat cells (rBMSCs) osteogenesis were cultured presence or absence varied size, 0.9µm, 2.7µm, 6.9µm, respectively. Flow cytometry...
Background: Preliminary research has shown an inhibited growth rate of well-differentiated laryngeal squamous cell carcinoma cells (FD-LSC-1) in below-background radiation (BBR), but how the respond to this environmental stress and potential mechanisms are yet unknown. The current study aimed reveal molecular differences grown under BBR conditions normal at transcriptional level. Methods: expression profiles between FD-LSC-1 a deep underground laboratory above ground collected on day 4 were...