A5063241635- Antimicrobial Peptides and Activities
- Biochemical and Structural Characterization
- Venomous Animal Envenomation and Studies
- Invertebrate Immune Response Mechanisms
- Gut microbiota and health
- Genomics, phytochemicals, and oxidative stress
- Natural product bioactivities and synthesis
- Diet and metabolism studies
- Seaweed-derived Bioactive Compounds
- Circadian rhythm and melatonin
- Natural Compound Pharmacology Studies
- Heavy metals in environment
- Protein Hydrolysis and Bioactive Peptides
- Toxoplasma gondii Research Studies
- RNA Research and Splicing
- Plant-derived Lignans Synthesis and Bioactivity
- Silk-based biomaterials and applications
- Machine Learning in Bioinformatics
- Ferroptosis and cancer prognosis
- Esophageal and GI Pathology
- Ophthalmology and Visual Impairment Studies
- MicroRNA in disease regulation
- IL-33, ST2, and ILC Pathways
- vaccines and immunoinformatics approaches
- Lower Extremity Biomechanics and Pathologies
Wenzhou University
2017-2025
Second Military Medical University
2023
Peking University
2023
Nanning Normal University
2022
Queen's University Belfast
2016-2020
Sargassum fusiforme fucoidan (SFF) exhibits diverse biological activities. Insulin resistance (IR) implicated in type 2 diabetes (T2D) has become an epidemic health issue worldwide. In this study, we investigated whether SFF can improve insulin sensitivity high-fat diet (HFD)-fed mice. Our present data showed that significantly reduced fasting blood glucose and IR index along with improved tolerance. Impaired phosphorylation of Akt was also restored by SFF. Furthermore, decreased the levels...
Insulin resistance is a characteristic feature of type 2 diabetes. Sulforaphane (SFN) natural antioxidant extracted from the cruciferous vegetables. Recent study reported that SFN exhibits excellent anti-diabetic effects, however, underlying mechanism still unclear. This aimed to investigate therapeutic effects on high-fat diet (HFD)-induced insulin and potential mechanism. was found effectively reduce body weight, fasting blood glucose hyperlipidemia, improve liver function in HFD-fed mice....
The dermaseptin antimicrobial peptide family contains members of 27-34 amino acids in length that have been predominantly isolated from the skins/skin secretions phyllomedusine leaf frogs. By use a degenerate primer Rapid amplification cDNA ends (RACE) PCR designed to common conserved domain within 5'-untranslated regions previously-characterized encoding cDNAs, two novel this family, named dermaseptin-PD-1 and dermaseptin-PD-2, were identified skin secretion frog, Pachymedusa dacnicolor....
Antimicrobial peptides (AMPs) in the skin secretions of amphibians are fundamental components a unique defense system that has evolved to protect these hosts from microbial invasion. Medusins constitute recently-discovered AMP family phyllomedusine leaf frog and exhibit highly-conserved structural characteristics. Here, we report novel medusin, medusin-PT, secretion Tarsier Leaf Frog, Phyllomedusa tarsius. The mature peptide was initially identified its cloned biosynthetic precursor-encoding...
Metformin is widely used to surmount insulin resistance (IR) and type 2 diabetes. Accumulating evidence suggests that metformin may improve IR through regulating gut microbiota bile acids. However, the underlying mechanisms remain unclear. Our metabolomic analysis showed significantly increased accumulation of tauroursodeoxycholic acid (TUDCA) in intestine liver from high-fat diet (HFD)-induced mice. TUDCA also alleviated IR, reduced oxidative stress intestinal inflammation ob/ob blocked...
Antimicrobial peptides belonging to the phylloseptin family are mainly found in phyllomedusine frogs. These not only possess potent antimicrobial activity but exhibit low toxicity against eukaryotic cells. Therefore, they considered as promising drug candidates for a number of diseases. In recent study, was correlated with conserved structures and cationic amphiphilic characteristics members this peptide family. A precursor discovered here skin secretion Phyllomedusa tarsius mature validated...
Chlordane, a previously extensively utilized insecticidal pesticide, has since been prohibited, however, owing to its limited degradability, it continues persist significantly in soil and water reservoirs, subsequently accumulating within plant animal organisms, representing substantial threat human health. Despite extensive research conducted over the past few decades investigate toxic effects of chlordane, there remains notable dearth studies focusing on impact sleep activity. Therefore,...
Obesity is associated with significant microvascular complications including renal injuries and may induce end-stage disease. Emerging studies have demonstrated microRNAs (miRNAs) are potential mediators in the pathophysiological process of nephropathy. The present study aimed to investigate role miR-802 obesity-related nephropathy molecular mechanisms. Through utilizing obese mouse model human subjects, we explored therapeutic benefits clinical application protecting against Renal level was...
Antimicrobial peptides (AMPs) are promising therapeutic alternatives compared to conventional antibiotics for the treatment of drug-resistant bacterial infections. However, application overwhelming majority AMPs is limited because high toxicity and manufacturing costs. Amphibian skin secretion has been proven be a source discovery development novel AMPs. Herein, we discovered AMP from Odorrana schmackeri, designed analogues by altering key factors, including conformation, net charge...
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The therapeutic potential of fucoidan (FUC), a natural polysaccharide, in metabolic disorders is recognized, yet its underlying mechanisms remain unclear. We conducted investigations into the FUC sourced from Sargassum fulvellum concerning induced by high-sucrose diet (HSD), employing Drosophila melanogaster and mice models. larvae were subjected to HSD exposure monitor growth inhibition, reduced pupation, developmental delays. Additionally, we examined impact on growth- development-related...
Schisandrin B (Sch B), an active extract of Schisandra chinensis, has demonstrated antioxidant activity in a number vitro and vivo models. In the present study, capacity Sch to protect against oxidative injury keratinocytes using human keratinocyte‑derived HaCaT cell line was investigated. To induce injury, tert‑Butyl hydroperoxide (tBHP) employed. The results indicate that efficiently reduced tBHP‑induced death, reactive oxygen species (ROS) generation, protein oxidation, lipid peroxidation...
Objective: Acne is a chronic skin disease that involves four key pathogenic factors: excess sebum production, ductal epidermal hyperproliferation, Propionibacterium acnes (P. acnes) colonization, and inflammation. Mangostins are well-known for their anti-bacterial anti-inflammatory effects, suggesting mangostins may have therapeutic potential acne. The present study aimed to explore the anti-acne effects of from perspective multiple mechanisms acne.Methods: α- γ-mangostins on growth P....
Amphibian skin secretions are unique sources of bioactive molecules, particularly peptides. In this study, the secretion white-lipped tree frog (Litoria infrafrenata) was obtained to identify peptides with putative therapeutic potential. By utilizing secretion-derived mRNA, a cDNA library constructed, frenatin gene cloned and its encoded were deduced confirmed using RP-HPLC, MALDI-TOF MS/MS. The identified as 4.1 (GFLEKLKTGAKDFASAFVNSIKGT) post-translationally modified peptide, 4.2...
Phylloseptin (PS) peptides, derived from South American hylid frogs (subfamily Phyllomedusinae), have been found to broad-spectrum antimicrobial activities and relatively low haemolytic activities. Although PS peptides identified several well-known widely-distributed species of the Phyllomedusinae, there remains merit in their study additional, more obscure specialised members this taxon. Here, we report discovery two novel named PS-Du PS-Co, which were respectively for first time isolated...
Amphibian skin secretions are an important treasure house of bioactive antimicrobial peptides (AMPs). Despite having been the focus decades research in this context, investigations phyllomedusine frogs continue to identify new AMPs from their secretions. In study, prototype a novel family AMP distinctin-like-peptide-PH (DLP-PH) was identified secretion otherwise well-studied Tiger-Legged Tree Frog Phyllomedusa hypochondrialis through cloning its precursor-encoding cDNA secretion-derived...
The Bowman–Birk protease inhibitor (BBI) family is a prototype group found mainly in plants, particularly grasses and legumes, which have been subjected to decades of study. Recently, the discovery attenuated peptides containing canonical inhibitory motif has detected skin secretions amphibians, from Ranidae members. roles these amphibian defense proposed work cooperatively with antimicrobial reduce peptide degradation. A novel trypsin peptide, named livisin, was secretion green cascade...
Abstract Proinflammatory cytokines/chemokines are commonly regulated by RNA-binding proteins at posttranscriptional levels. Human Ag R (HuR)/embryonic lethal abnormal vision-like 1 (ELAVL1) is one of the well-characterized that increases stability short-lived mRNAs, which encode proinflammatory mediators. HuR employs its nucleocytoplasmic shuttling sequence (HNS) domain, interacting with poly(ADP-ribose) polymerase (PARP1), accounts for enhanced poly-ADP-ribosylation and cytoplasmic HuR....