A5100364425- Advanced biosensing and bioanalysis techniques
- Electrochemical sensors and biosensors
- Biosensors and Analytical Detection
- DNA and Nucleic Acid Chemistry
- RNA Interference and Gene Delivery
- Advanced Nanomaterials in Catalysis
- Advanced Biosensing Techniques and Applications
- RNA and protein synthesis mechanisms
- Electrochemical Analysis and Applications
- Carbon and Quantum Dots Applications
- Molecular Sensors and Ion Detection
- Click Chemistry and Applications
- Pharmacological Effects and Assays
- Bacteriophages and microbial interactions
- Nanopore and Nanochannel Transport Studies
- Molecular Junctions and Nanostructures
- Pharmaceutical and Antibiotic Environmental Impacts
- interferon and immune responses
- Metal complexes synthesis and properties
- Polymer Surface Interaction Studies
- 2D Materials and Applications
- Microplastics and Plastic Pollution
- Photodynamic Therapy Research Studies
- Mycotoxins in Agriculture and Food
- Drug Transport and Resistance Mechanisms
Hefei University of Technology
2018-2024
Yangzhou University
2024
Liaocheng University
2021-2023
Institute of Intelligent Machines
2023
Huaqiao University
2023
Zhejiang Sci-Tech University
2023
State Key Laboratory of Chemobiosensing and Chemometrics
2022
Hunan University
2022
Shangqiu Normal University
2022
Xi'an Jiaotong University
2021-2022
Label-free MoS2 nanosheet-based field-effect biosensor detects cancer marker protein Prostate Specific Antigen in real time with high sensitivity and selectivity, exhibiting great potential point-of-care diagnostics application.
Both disease diagnosis and therapeutic treatments require real-time information from assays capable of identifying multiple targets. Among various multiplexed biochips, suspension quantum dot (QD)-encoded microspheres are highly advantageous. This arises the excellent fluorescent properties QDs incorporated into these microspheres, thus allowing them to serve as "QD barcodes". QD barcodes can be prepared through approaches. However, formulation improved synthetic techniques that may allow...
Abstract Azido 18 F‐arenes are important and versatile building blocks for the radiolabeling of biomolecules via Huisgen cycloaddition (“click chemistry”) positron emission tomography (PET). However, routine access to such clickable agents is challenged by inefficient and/or poorly defined multistep radiochemical approaches. A high‐yielding direct radiofluorination azido was achieved through development an ortho ‐oxygen‐stabilized iodonium derivative (OID). This OID strategy addresses unmet...
As one of the most toxic forms arsenic, inorganic As(III) is easy to accumulate in rice, leading severe public health problems. Effective control requires development fast analytical methods for its detection with high sensitivity and specificity. Toward this end, work, we report fabrication an electrochemical sensor based on a solution-gated graphene transistor (SGGT) platform novel sensing mechanism. The gold gate electrode SGGT was modified DNA probes then blocked bovine serum albumin...
The capacity to precisely modulate aptamer affinity is important for a wide variety of applications. However, most such engineering strategies entail laborious trial-and-error testing or require prior knowledge an aptamer's structure and ligand-binding domain. We describe here simple generalizable strategy allosteric modulation by employing double-stranded molecular clamp that destabilizes secondary through mechanical tension. demonstrate the effectiveness approach with thrombin-binding show...
Fluorescent light-up RNA aptamers (FLAPs) have become promising tools for visualizing RNAs in living cells. Specific binding of FLAPs to their non-fluorescent cognate ligands results a dramatic fluorescence increase, thereby allowing imaging. Here, we present color-shifting aptamer-fluorophore system, where the free dye is cyan fluorescent and aptamer-dye complex near-infrared (NIR) fluorescent. Unlike other reported FLAPs, this system enables ratiometric To design synthesized series...
Most biosensors relying on antibodies as recognition elements fail in harsh environment conditions such elevated temperatures, organic solvents, or proteases because of antibody denaturation, and require strict storage with defined shelf life, thus limiting their applications point-of-care resource-limited settings. Here, a metal–organic framework (MOF) encapsulation is utilized to preserve the biofunctionality conjugated nanotransducers. This study investigates several parameters MOF...
Abstract The development of plant viral nanoparticles (VNP) loaded with different molecular versions a photodynamic drug is described. Specifically, tobacco mosaic virus (TMV) and mild green (TMGMV) are developed as carriers that encapsulate the monocationic, dicationic, tricationic, tetracationic porphyrin‐based photosensitizer (Zn‐Por). While TMV has been extensively explored for various nanotechnology applications, this first study investigating TMGMV medical applications. Light‐activated...
Cytometric bead assays have caught much attention because of their many exceptional advantages. Unfortunately, the immobilization existing molecular recognition elements including monoclonal antibodies and aptamers onto solid particles may lead to functional failure since they are generally obtained in free state. Herein we develop a powerful screening approach for direct rapid discovery aptamer based cytometric (AB-CBAs) by individually measuring activity every library sorting them at rates...