A5088183888- Transgenic Plants and Applications
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Bacteriophages and microbial interactions
- Plant Virus Research Studies
- Mosquito-borne diseases and control
- Atherosclerosis and Cardiovascular Diseases
- CAR-T cell therapy research
- Antimicrobial Peptides and Activities
- Polymer Surface Interaction Studies
- Photodynamic Therapy Research Studies
- S100 Proteins and Annexins
- interferon and immune responses
- Toxin Mechanisms and Immunotoxins
- Influenza Virus Research Studies
- Characterization and Applications of Magnetic Nanoparticles
- Virus-based gene therapy research
- Hemoglobinopathies and Related Disorders
- Respiratory viral infections research
- Galectins and Cancer Biology
- Biosensors and Analytical Detection
- Viral Infections and Vectors
- Viral Infections and Outbreaks Research
- SARS-CoV-2 detection and testing
- Monoclonal and Polyclonal Antibodies Research
University of California, San Diego
2018-2022
Case Western Reserve University
2018-2019
University of Utah
2015-2017
Amine/thiol-reactive chemistries are commonly used to conjugate antibodies pharmaceuticals or nanoparticles. Yet, these conjugation strategies often result in unfavorable outcomes such as heterogeneous antibody display with hindered biological activity aggregation due multivalent interactions of the and Here, we report application a site-specific enzymatically driven strategy functionalize virus-based nanoparticles (VNPs). Specifically, an azide-handle was introduced into Fc region set...
Abstract Prognosis and treatment of metastatic cancer continues to be one the most difficult challenging areas oncology. Treatment usually consists chemotherapeutics, which may ineffective due drug resistance, adverse effects, dose‐limiting toxicity. Therefore, novel approaches such as immunotherapy have been investigated improve patient outcomes minimize side effects. S100A9 is a calcium‐binding protein implicated in tumor metastasis, progression, aggressiveness that modulates...
Tobacco mosaic viral delivery of thrombolytics increases safety profile the therapy.
Abstract The development of plant viral nanoparticles (VNP) loaded with different molecular versions a photodynamic drug is described. Specifically, tobacco mosaic virus (TMV) and mild green (TMGMV) are developed as carriers that encapsulate the monocationic, dicationic, tricationic, tetracationic porphyrin‐based photosensitizer (Zn‐Por). While TMV has been extensively explored for various nanotechnology applications, this first study investigating TMGMV medical applications. Light‐activated...
TMV-based plant virus nanoparticles targeting S100A9 exhibited high specificity to atherosclerotic lesions in ApoE<sup>−/−</sup> mice, which provides a new diagnostic strategy for atherosclerosis with risk factors.
Stable suspensions of magnetic nanoparticles (MNPs) with large moment, m, per particle have tremendous utility in a wide range biological applications. However, because the strong coupling interactions often present these systems, it is challenging to stabilize individual, high-moment, ferro- and ferrimagnetic nanoparticles. A novel approach encapsulate large, that is, >100 nm, zinc ferrite nanocubes (ZFNCs) silica after an intermediary layer-by-layer polyelectrolyte deposition step...
Magnetic particles are widely used as labels in magnetoresistive sensors. To use magnetic labels, several important characteristics should be considered, such superparamagnetism, a high moment per particle (m), facile surface functionalization and biomolecule immobilization, colloidal stability, analyte specificity. In this paper, we describe the preparation of with m, using assemblies superparamagnetic zinc ferrite nanoparticles (ZFNPs, ∼9 nm). Also, properties these compared those...
Thromboembolic conditions are a leading cause of death worldwide, and deep vein thrombosis (DVT), or occlusive venous clot formation, is critical rising problem that contributes to damage vital organs, long-term complications, life-threatening such as pulmonary embolism. Early diagnosis treatment correlated better prognosis. However, current technologies in these areas, ultrasonography for diagnostics anticoagulants treatment, limited terms their accuracy therapeutic windows. In this work,...
Abstract The current study investigates the use of an immunostimulatory plant virus nanoparticle called cowpea mosaic (CPMV) in both prophylaxis and treatment metastatic breast cancer melanoma. Metastatic remains to this day one most difficult areas oncology treat diagnose. Current standardized treatments consist systemically administered chemotherapeutics, which are not targeted diseased oftentimes cause significant side effects. Therefore, novel such as immunotherapies under development....