A5100347750- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Cancer Mechanisms and Therapy
- MRI in cancer diagnosis
- Liver Disease and Transplantation
- Cancer Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Renal cell carcinoma treatment
- Colorectal Cancer Treatments and Studies
- Liver physiology and pathology
- Cancer Immunotherapy and Biomarkers
- Pneumonia and Respiratory Infections
- Vaccine Coverage and Hesitancy
- Immune Cell Function and Interaction
- Immune cells in cancer
- Ultrasound Imaging and Elastography
- Single-cell and spatial transcriptomics
- Ferroptosis and cancer prognosis
- Inflammatory Biomarkers in Disease Prognosis
- Ultrasound and Hyperthermia Applications
- Hepatitis Viruses Studies and Epidemiology
- Cancer Genomics and Diagnostics
- Respiratory viral infections research
The First Affiliated Hospital, Sun Yat-sen University
2019-2024
Sun Yat-sen University
2015-2024
Shandong First Medical University
2023-2024
Guizhou Center for Disease Control and Prevention
2023-2024
Shandong Provincial Hospital
2023-2024
Peking University
2015-2023
Peking University Cancer Hospital
2015-2023
Third Hospital of Hebei Medical University
2022
Hebei Medical University
2022
Institute of Electrical and Electronics Engineers
2022
Patients with intermediate or locally advanced hepatocellular carcinoma (HCC) who are not eligible for radical treatment typically have a poor overall prognosis. Treatment strategies that can convert unresectable HCC into resectable may improve patient survival. We conducted single arm phase 2 trial to evaluate the efficacy and safety of Sintilimab plus Lenvatinib as conversion therapy HCC.A single-arm, single-center study in China (NCT04042805). Adults (≥18 years) Barcelona Clinic Liver...
Abstract Purpose This trial evaluated the addition of cetuximab to a modified FOLFOXIRI (mFOLFOXIRI: 5-fluorouracil/folinic acid, oxaliplatin, irinotecan) as conversion therapy in two-group, nonrandomized, multicenter, phase II patients with initially technically unresectable colorectal liver-limited metastases (CLM) and BRAF/RAS wild-type. Patients Methods were enrolled receive (500 mg/m2) plus mFOLFOXIRI (oxaliplatin 85 mg/m2, irinotecan 165 folinic acid 400 5-fluorouracil 2,800 mg/m2...
The prognosis of adrenal metastases (AM) from hepatocellular carcinoma (HCC) with surgical contraindication was poor. This study evaluated the feasibility, safety and treatment efficacy percutaneous ultrasound (US)-guided radiofrequency ablation (RFA) for local AM originated HCC.A retrospective carried out on 22 patients (21 male 1 female, mean age, 53.0 ± 13.0 years) who had single (mean diameter, 4.0 1.8 cm, range, 1.7-8.0 cm) HCC received US-guided RFA at our institution. diagnosis...
Purpose: To retrospectively compare the treatment outcome of multiple-electrode switching-based radiofrequency ablation (switching RFA) and conventional RFA for early-stage hepatocellular carcinoma (HCC). Methods: A total 122 patients with single HCC ranging from 2.1 to 5.0 cm received ultrasonography-guided percutaneous as first-line treatment. Seventy-one underwent switching RFA, 51 RFA. Tumor response, major complication, local tumor progression (LTP), overall survival (OS) were compared...
Objectives To establish a modified strategy of the feeding artery ablation (FAA) procedure as an add-on to percutaneous radiofrequency (RFA) for patients with hypervascular hepatocellular carcinoma (HCC), and evaluate outcomes.Materials methods For this prospective, single-arm study, from June 2014 August 2016, twenty-five HCC, 2–5 cm in diameter were treated by contrast-enhanced ultrasound (CEUS)-guided FAA before conventional RFA. Technical success subsequent perfusion change tumor...
Sorafenib, lenvatinib and regorafenib, the multi-RTK inhibitors with potent anti-angiogenesis effects, are currently therapeutic drugs generally recommended for patients advanced hepatocellular carcinoma (HCC). To date, however, there have been no published studies on mechanism underling differential effects of three HCC cell proliferation, proteomic analysis in lines treated by regorafenib or lenvatinib. The present study first time performed a direct comparison cycle arrest apoptosis...
The objective of our study was to prospectively evaluate the feasibility, effectiveness, and safety 1.0T open multiparametric magnetic resonance (MR)-guided monitored microwave ablation (MWA) liver cancer.Fifty-six lesions (12 - initial hepatocellular carcinoma, 34 recurrent 10 metastatic cancers) in 45 patients were treated with MWA using MR guidance monitoring. mean diameter 1.7 ± 0.9 cm (range, 0.5-4.6 cm). 56 divided into 3 groups according diameter: <1.0 group (17 lesions), 1.0-2.0 (19...
To evaluate the local efficacy, safety, and long-term outcomes of combined radiofrequency ablation (RFA) multipronged ethanol (EA) in treatment unfavorable hepatocellular carcinoma (HCC) to determine prognostic factors for survival.Between August 2009 December 2017, 98 patients with 110 HCC nodules who underwent RFA EA were retrospectively enrolled study. Unfavorable was defined as a medium (3.1-5.0 cm) or large (5.1-7.0 nodule, tumor located at high-risk site, perivascular tumor. The...
Infant hepatitis B vaccine coverage in China is high, with over 95% of infants immunized; however, high can often mask low timeliness. The vaccination interval between the second and third doses not clearly defined by immunization guidelines China. This retrospective cohort study assessed time distribution among a randomly selected live births from Centers for Disease Control Prevention across four provinces or municipalities January 2017 December 2021. Among analyzed, 163,224 received first...
Objectives This study aimed to investigate and compare 2‐dimensional shear wave elastography (2D‐SWE) measurements influencing factors among 2 different devices evaluate the ability of these assess liver fibrosis. Methods From October 2022 September 2023, 290 hepatocellular carcinoma (HCC) patients 30 healthy volunteers were prospectively included. The 2D‐SWE performed using AixPlorer V (SEmean) APLIO i900 (CEmean). compared between instruments for evaluating fibrosis stage analyzed...
Objective To study the feasibility, efficacy and safety of ultrasound-guided percutaneous radiofrequency ablation (RFA) in treatment hepatocellular carcinoma (HCC) caudate lobe. Methods From November 2006 to June 2017, 31 patients with HCCs located lobe were treated RFA at First Affiliated Hospital Sun Yat-sen University. The efficacy, complications, local tumor progression (LTP), disease-free survival (DFS) overall (OS) rates analyzed. Results Residual tumors detected 5 after...
The meningococcal meningitis (MM) vaccine reduces the incidence of MM significantly; however, outbreaks still occur in communities with high coverage. We aimed to analyze driving factors infection from a community outbreak. A total 266 children aged 9 15 years old three junior schools Tongzi county were identified. documented cases using laboratory tests and analyzed attack rates, rates risk for transmission. index case School was identified, rate 0.03%. Children showed significantly low...
Objective To analyze the influence factors of local efficacy by parametric contrast enhanced ultrasound (CEUS) hepatocellular carcinoma (HCC) patient treated with transcatheter arterial chemoembolization (TACE), and to investigate application value CEUS in TACE. Methods From August 2011 March 2014, a total 61 HCC patients [60 men, 1 women; age range: 18-76 years, mean age: (53±13)years old] who underwent one procedure TACE were enrolled this prospective study. All cases scanned 1-7...