A5112428176- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis Viruses Studies and Epidemiology
- Reproductive Biology and Fertility
- Cancer Mechanisms and Therapy
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Lung Cancer Treatments and Mutations
- Abdominal vascular conditions and treatments
- Birth, Development, and Health
- Catalysis and Hydrodesulfurization Studies
- Endometriosis Research and Treatment
- Robotic Path Planning Algorithms
- Assisted Reproductive Technology and Twin Pregnancy
- Radiopharmaceutical Chemistry and Applications
- Pelvic floor disorders treatments
- Ovarian cancer diagnosis and treatment
- Ovarian function and disorders
- Wireless Sensor Networks and IoT
- Endometrial and Cervical Cancer Treatments
- Renal and Vascular Pathologies
- Osteoarthritis Treatment and Mechanisms
- Complement system in diseases
Tianshui Normal University
2023-2025
Air Force Medical University
2015-2024
Xijing Hospital
2015-2024
National Clinical Research Center for Digestive Diseases
2017-2024
Huazhong University of Science and Technology
2024
Northwest University
2023
Lanzhou University
2022-2023
Nanjing University of Chinese Medicine
2022
Jiangsu Province Hospital
2022
Guiyang Medical University
2022
Abstract Renal fibrosis is the common pathological feature in a variety of chronic kidney diseases. Aging highly associated with progression renal fibrosis. Among several determinants, mitochondrial dysfunction plays an important role aging. However, underlying mechanisms age‐related are not elucidated. Herein, we found that Wnt/β‐catenin signaling and renin–angiotensin system (RAS) activity were upregulated aging kidneys. Concomitantly, mass functions impaired Ectopic expression Klotho,...
Objective Limited data are available on the prevention of variceal rebleeding in cirrhotic patients with portal vein thrombosis (PVT). This study aimed to compare transjugular intrahepatic portosystemic shunt (TIPS) covered stents versus endoscopic band ligation (EBL) plus propranolol for among cirrhosis and PVT. Design Consecutive (94% Child-Pugh class A or B) PVT who had bleeding past 6 weeks were randomly assigned TIPS group (n=24) EBL (EBL+drug, n=25), respectively. Primary endpoint was...
To evaluate the long-term outcomes of percutaneous recanalization and determine predictors patency survival in a large case series Chinese patients with Budd-Chiari syndrome (BCS).This retrospective study was approved by institutional ethics committee. Informed consent for procedure obtained from all patients. Between July 1999 August 2010, 177 consecutive primary BCS were treated followed up until death or their last clinical evaluation. Recanalization therapeutic strategy complications...
Objectives Early placement of transjugular intrahepatic portosystemic shunt (TIPS) has been shown to improve survival in high-risk patients (Child-Pugh B plus active bleeding at endoscopy or Child-Pugh C 10–13) with cirrhosis and acute variceal (AVB). However, early TIPS criteria may overestimate the mortality risk a significant proportion patients, benefit conferred by such questioned. Alternative have proposed refine used identify candidates for TIPS. Nevertheless, true provided (or not)...
Temporal development of the human gut microbiome from infancy to childhood is driven by a variety factors. We surveyed fecal 729 Chinese children aged 0-36 months, aiming identify age-specific patterns microbiota succession, and evaluate impact birth mode, gender, geographical location, gastrointestinal tract symptoms on shaping microbiome. demonstrated that phylogenetic diversity increased gradually over time, which was accompanied an increase in Bacteroidetes reduction Proteobacteria...
In Western countries, transjugular intrahepatic portosytemic shunt (TIPS) is widely applied for the treatment of Budd-Chiari syndrome (BCS). However, outcome Chinese BCS patients treated with TIPS extremely limited. Furthermore, timing conversion from percutaneous recanalization to remains uncertain.All consecutive between December 2004 and June 2012 were included. Patients classified as early converted groups. Indications, TIPS-related complications, post-TIPS hepatic encephalopathy,...
INTRODUCTION: Current guidelines recommend anticoagulation as the mainstay of portal vein thrombosis (PVT) treatment in cirrhosis. However, because heterogeneity PVT, alone does not always achieve satisfactory results. This study aimed to prospectively evaluate an individualized management algorithm using a wait-and-see strategy (i.e., no treatment), anticoagulation, and transjugular intrahepatic portosystemic shunt (TIPS) treat PVT METHODS: Between February 2014 June 2018, 396 consecutive...
The role of transjugular intrahepatic portosystemic shunt (TIPS) for the secondary prophylaxis variceal bleeding in cirrhotic patients with portal vein thrombosis (PVT) remains obscure. This prospective cohort study aimed to assess risk factors associated TIPS technical success, outcome and prognosis PVT a history bleeding.Between May 2009 April 2011, 51 who attempted procedures prevention rebleeding were enrolled.TIPS success rate was 84% (43/51). An increased degree within trunk branches...
Automatic detection and alarm of abnormal electrocardiogram (ECG) events play an important role in ECG monitor system; however, popular classification models based on supervised learning fail to detect effectively. Thus, we propose anomaly framework (ECG-AAE) adversarial autoencoder temporal convolutional network (TCN) which consists three modules (autoencoder, discriminator, outlier detector). The ECG-AAE is trained only with normal data. Normal signals could be mapped into latent feature...
Tubular epithelial cell apoptosis contributes to tubulointerstitial fibrosis but its regulation remained unclear. Here, in fibrotic kidney induced by unilateral ureteral obstruction (UUO), we demonstrated that miR-34a was markedly up-regulated spaces and microvesicles isolated from kidney. However, the increased not de novo synthesized proximal tubular cells fibroblasts after incubated with TGF-β1. MiR-34a culture media of TGF-β1 treated fibroblasts. These acted as a vector for delivery...
Oxidative stress plays an important role in the pathogenesis of various liver diseases. Safflower yellow B (SYB) has been reported to protect brain against damage induced by oxidative stress; however, whether SYB can also hepatocytes from remains unknown. In present study, determine pre-treatment with reduces hydrogen peroxide (H2O2)‑induced HepG2 cells, we investigated H2O2-induced cells treated or without SYB. Cell viability was measured MTT assay and cytotoxicity evaluated lactate...
Background Use of TIPSS is associated with increases in ammonia concentration and hepatic encephalopathy (HE) risk. l-ornithine-l-aspartate (LOLA) effective reducing concentration. Aim To evaluate the effects LOLA on venous after TIPSS. Methods The included patients were randomised to receive or no-LOLA treatment for 7 days. Fasting post-prandial levels primary outcomes. Psychometric performance, post-TIPSS HE, liver renal function assessed as secondary Results Of 133 cirrhotic who received...
Abstract This retrospective cohort study aimed to evaluate the prognostic value of alpha-fetoprotein (AFP) response in advanced-stage hepatocellular carcinoma (HCC) patients treated with sorafenib combined transarterial chemoembolization. From May 2008 July 2012, 118 HCC baseline AFP levels >20 ng/ml combination therapy were enrolled. A receiver operating characteristic curve was used generate a cutoff point for changes predicting survival. The defined as an decrease rate [ΔAFP(%)]...
Background and Aims Optimal candidates for early transjugular intrahepatic portosystemic shunt (TIPS) in patients with Child‐Pugh B cirrhosis acute variceal bleeding (AVB) remain unclear. This study aimed to test the hypothesis that risk stratification using Chronic Liver Failure Consortium Acute Decompensation score (CLIF‐C ADs) may be useful identify a subgroup at high of mortality or further benefit from TIPS AVB. Approach Results We analyzed pooled individual data two previous studies...