A5046519793- Noise Effects and Management
- Structural Health Monitoring Techniques
- Acoustic Wave Phenomena Research
- Vehicle Noise and Vibration Control
- Topic Modeling
- Biomedical Text Mining and Ontologies
- Advanced Algorithms and Applications
- Cancer therapeutics and mechanisms
- Probabilistic and Robust Engineering Design
- Advancements in Transdermal Drug Delivery
- Composite Structure Analysis and Optimization
- Topology Optimization in Engineering
- Cell death mechanisms and regulation
- Numerical methods in engineering
- Hearing Loss and Rehabilitation
- Bioactive Compounds and Antitumor Agents
- Cancer Cells and Metastasis
- Pharmacological Effects of Natural Compounds
- Natural Language Processing Techniques
- Geoscience and Mining Technology
- Solar Energy Systems and Technologies
- Hypothalamic control of reproductive hormones
- Ultrasonics and Acoustic Wave Propagation
- HER2/EGFR in Cancer Research
- Bladed Disk Vibration Dynamics
Seventh People's Hospital of Shanghai
2025
Chinese Academy of Agricultural Sciences
2017-2025
Institute of Plant Protection
2017-2025
Zhejiang University of Science and Technology
2017-2024
Qingdao University
2024
Qingdao Municipal Hospital
2024
Affiliated Hospital of Qingdao University
2024
Anhui University of Traditional Chinese Medicine
2017-2024
Chengdu Medical College
2023
Dalian University of Foreign Languages
2021-2023
Abstract Background The standard first‐line treatment for human epidermal growth factor receptor 2 (HER2)‐positive recurrent/metastatic breast cancer currently includes pertuzumab plus trastuzumab and docetaxel. This study aimed to evaluate the effectiveness of KN026, an anti‐HER2 bispecific antibody, docetaxel in HER2‐positive cancer. Methods open‐label, single‐arm, phase II enrolled patients with 19 centers across China from December 30, 2019 May 27, 2021. Patients were administered KN026...
Fast and powerful: A polyelectrolyte multilayer film was used to fabricate a humidity-responsive actuator that can drive walking device carrying load 120 times heavier than the walk steadily on ratchet substrate under periodic alternation of relative humidity (RH) between 11 40 % (see picture). NOA 63: Norland Optical Adhesive 63, PAA: poly(acrylic acid), PAH: poly(allylamine hydrochloride). Detailed facts importance specialist readers are published as "Supporting Information". Such...
Drug-drug interactions (DDIs) often bring unexpected side effects. The clinical recognition of DDIs is a crucial issue for both patient safety and healthcare cost control. However, although text-mining-based systems explore various methods to classify DDIs, the classification performance with regard in long complex sentences still unsatisfactory. In this study, we propose an effective model that classifies from literature by combining attention mechanism recurrent neural network short-term...
Epithelial-to-mesenchymal transition (EMT) and cancer stem-like cells (CSLCs) play crucial role in tumor metastasis drug-resistance. Disheveled3 (DVL3) is involved malignant behaviors of cancer. However, the potential mechanism DVL3 remain elusive EMT CSLCs colorectal (CRC).
Schnell und leistungsfähig: Aus einem mehrlagigen Polyelektrolytfilm wurde ein feuchtigskeitsempfindlicher Aktuator hergestellt, der einen molekularen Läufer antreibt, durch periodischen Wechsel relativen Feuchte (RH) zwischen 11 40 % auf gerippten Substrat entlangschreitet (siehe Bild) dabei das 120-fache Gewicht des Aktuators trägt. NOA 63: Norland Optical Adhesive 63, PAA: Polyacrylsäure, PAH: Poly(allylaminhydrochlorid). Detailed facts of importance to specialist readers are published as...
Currently, there is no reliable biomarker to clinically predict the prognosis of lung adenocarcinoma (ADC). The receptor-tyrosine-kinase like orphan receptor 1 (ROR1) reported be overexpressed and associated with poor in several tumors. This study aimed examine expression ROR1 evaluate its prognostic significance human ADC patients. In this present study, Western blot analysis immunohistochemistry were performed characterize protein results revealed that was significantly higher tissues than...
Unmanned aerial vehicle (UAV) technologies are rapidly advancing due to the unlimited number of applications from parcel delivery people transportation. As UAV market expands, community noise impact will become a significant problem for public acceptance. Compact drone architectures based on contra-rotating propellers bring benefits in terms aerodynamic performance and redundancy ensure control case component failure. However, severely noisy if not designed appropriately. In framework...
The present study was to investigate the anticancer effect of chloroquine on proliferation mouse colon cancer cell line CT26 in vivo and vitro possible mechanism. We found that inhibited by concentration- time-dependent manner. This associated with apoptosis induction decreased level phosphorylated p42/44 mitogen-activated protein kinase Akt. showed chloroquine-reduced tumor volume prolonged survival time CT26-bearing mice. These observations indicated could inhibit inducing both vivo,...
Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer. OSCC cells are highly invasive, a characteristic that involves epithelial‑mesenchymal transition (EMT); conversion immotile epithelial into motile mesenchymal cells. EMT involved in progression various types cancer by promoting tumour scattering and conferring to these stem (CSC)‑like characteristics, such as self‑renewal. Hepatocyte growth factor (HGF) signalling plays an important role induction and, therefore,...
The aviation sector is rapidly evolving with more electric propulsion systems and a variety of new technologies vertical take-off landing manned unmanned aerial vehicles. Community noise impact one the main barriers for wider adoption these Within framework perception-driven engineering approach, this paper investigates relationship between sound quality first order physical parameters in rotor to aid design. Three case studies are considered: (i) contra-rotating versus single systems, (ii)...
The postnatal development of gonadal glands in seasonal breeders, particularly small rodent species, is influenced by photoperiodic patterns. However, little research has been conducted on the effects pattern similarity and age differentiation especially molecular features. This study compares expression hypothalamic genes related to reproductive regulation male offspring Brandt's voles (Lasiopodomys brandtii) born under three types changing patterns: increasing long photoperiod (ILP, 12 h +...
Chloroquine is an antimalarial drug that has been used in the treatment and prophylaxis of malaria since 1950s. The present study was undertaken to examine effects chloroquine on Bcap-37 human breast cancer cells’ growth, cell cycle modulation, apoptosis induction, associated molecular alterations vitro. decreased viability cells a concentration- time-dependent manner, which correlated with G2/M phase arrest. chloroquine-mediated arrest decrease protein levels/activity polo-like kinase 1...
Abstract Seasonal breeding is a universal reproductive strategy in many animals. Hypothalamic genes, especially type 2 and 3 iodothyronine deiodinases ( Dio2 / ), RFamide‐related peptide Rfrp‐3 kisspeptin Kiss‐1 ) gonadotropin‐releasing hormone GnRH are involved photoperiodic pathway that encodes seasonal signals from day length vertebrate species. However, the expression patterns of these genes wild mammals less studied. Here, we present four‐year field investigation to reveal rhythm...
Most of the existing methods neglect their complementary relation and only use welding pool images to detect defects. Therefore, a new triple pseudo-siamese network improve identification performance using complementarity is proposed in this paper. The consists three branches that extract effective features image, sound, current voltage, respectively. Moreover, we employ convolutional block attention module (CBAM) propose cross-modal (CMA) focus on vital regions image. To train our model,...
Particle swarm optimizations (PSOs) are drawing extensive attention from both research and engineering fields due to their simplicity powerful global search ability. However, there two issues needing be improved: one is that the classical PSO converges slowly; other tends result in premature convergence, especially for multi-modal problems. This paper attempts address these issues. Firstly, improve convergent efficiency, this proposes an asymptotic predicting model of globally-optimal...
Abstract Background Inflammation is a complex physiological and pathological process. Although many types of inflammation are well characterized, their functions largely unknown. tRNA aspartic acid methyltransferase 1 (TRDMT1) has been implicated as stress‐related protein, but its intrinsic biological role unclear. Methods We constructed Trdmt1 knockout rat adopted the LPS‐induced sepsis model. Survival curve, histopathological examination, expression inflammatory factors, protein level TLR4...