A5101592859- Cancer-related gene regulation
- Oral microbiology and periodontitis research
- Biochemical effects in animals
- Cancer Cells and Metastasis
- Olfactory and Sensory Function Studies
- Protein Hydrolysis and Bioactive Peptides
- Proteoglycans and glycosaminoglycans research
- Lung Cancer Treatments and Mutations
- Oral Health Pathology and Treatment
- Antimicrobial Peptides and Activities
- Wireless Communication Security Techniques
- Vasculitis and related conditions
- Primate Behavior and Ecology
- Medicinal plant effects and applications
- Fungal Biology and Applications
- Wnt/β-catenin signaling in development and cancer
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cryptography and Data Security
- Food Quality and Safety Studies
- Natural product bioactivities and synthesis
- dental development and anomalies
- Analytical Chemistry and Chromatography
- Nuts composition and effects
- Polydiacetylene-based materials and applications
- Bone Metabolism and Diseases
Sichuan University
2016-2024
State Key Laboratory of Oral Diseases
2020-2024
Macau University of Science and Technology
2024
Xi'an Medical University
2021
Air Force Medical University
2021
University of Macau
2017-2020
State Key Laboratory of Biotherapy
2019
First Hospital of Jilin University
2019
Jilin University
2019
Fairfield University
2016-2018
Currently, there is no reliable biomarker to clinically predict the prognosis of lung adenocarcinoma (ADC). The receptor-tyrosine-kinase like orphan receptor 1 (ROR1) reported be overexpressed and associated with poor in several tumors. This study aimed examine expression ROR1 evaluate its prognostic significance human ADC patients. In this present study, Western blot analysis immunohistochemistry were performed characterize protein results revealed that was significantly higher tissues than...
There is a lack of reliable prognosis biomarker in the current treatment colorectal cancer. The receptor-tyrosine-kinase-like orphan receptor 1 (ROR1) overexpressed and associated with poor certain tumors. This study aimed to explore prognostic significance ROR1 Western blot analysis immunohistochemistry showed that expression cancer was significantly higher than adjacent normal tissues. positively clinical stage lymph-node metastasis (p < 0.01). Kaplan-Meier survival revealed patients had...
Dental caries is a multifactorial disease primarily mediated by biofilm formation, resulting in net loss of mineral content and degradation organic matrix dental hard tissues. Caries lesions varying depths can result demineralization the superficial enamel, formation deep cavities extending into dentin, even pulp infection. Electrospun nanofibers (ESNs) exhibit an expansive specific surface area porous structure, closely mimicking unique architecture natural extracellular (ECM). This...
Ocean life contains a wealth of bioactive peptides that could be utilized in nutraceuticals and pharmaceuticals. This study aimed to obtain neuroprotective antioxidant sea squirt (Halocynthia roretzi) through protamex enzymolysis. Fraction F4 (ultrafiltration generated four fractions) had lower molecular weight (<500 Dalton (Da)) with greater 1,1-diphenyl-2-picrylhydrazyl (DPPH) 2,2-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt (ABTS) radical scavenging activities...
Notopterol, an active component isolated from the traditional Chinese medicine Notopterygium incisum Ting ex H.T. Chang, exerts anti-inflammatory activity in rheumatoid arthritis. However, its roles suppression of inflammatory insults and halting progression tissue destruction periodontitis remain elusive. In this study, we reveal that notopterol can inhibit osteoclastogenesis, thereby limiting alveolar bone loss vivo. vitro results demonstrated administration inhibited synthesis mediators...
Abstract Background Serving as a stop signal of inflammation, the role lipoxin A4 (LXA4) in periodontitis remains to be clarified. This study is aimed examine changes LXA4 levels gingival crevicular fluid (GCF) after scaling and root planing (SRP) determine relationship between treatment outcomes periodontal pathogens severe periodontitis. Methods A total 74 GCF samples were collected from 21 participants at deepest affected sites. These sites re-sampled 1, 3, 6 months SRP. Besides, also 25...
Anti-glomerular basement membrane (GBM) disease is an autoimmune disorder with rapidly progressive glomerulonephritis and alveolar haemorrhage. Fever symptoms prodromal infections have been reported in many cases, but still not elucidated.Our study enrolled 140 consecutive patients anti-GBM retrospectively analyzed the characteristics of fever possible reasons.Among patients, 94 (67.1%) presented (over 37.5°C) prior to admission or within 48 h hospitalization. Among those fever, 74 (78.7%)...
Slow lorises are enigmatic animal that represent the only venomous primate lineage. Their defensive secretions have received little attention. In this study we determined full length sequence of protein secreted by their unique brachial glands. The sequences displayed homology to main allergenic present in cat dander. We thus compared molecular features slow loris gland and dander allergen protein, showing remarkable similarities between them. Thus postulate proteins play a role arsenal....
Peanut (Arachis hypogaea) peptides have various functional activities and a high utilization value. This study aims to isolate characterize antioxidant from peanut protein hydrolysates further evaluate their neuroprotection against oxidative damage PC12 cells induced by 6-hydroxydopamine (6-OHDA). After the was hydrolyzed with pepsin purified using ultrafiltration gel chromatography, six were identified sequenced high-performance liquid chromatography (HPLC) chromatography-tandem mass...
Peanuts are a rich dietary source of lipids, which essential for human health. In this study, the lipid contents 13 peanut cultivars were analyzed using UPLC-Q-TOF-MS and GC-MS. The OXITEST reactor was used to test their oxidation stabilities. A total 27 subclasses, 229 individual lipids detected. combined analysis stability showed that unsaturation inversely correlated with stability. Moreover, profiles differed significantly among different cultivars. 11 molecules (TG 18:2/18:2/18:2, TG...
To explore the application of combined use baseline salivary biomarkers and clinical parameters in predicting outcome scaling root planing (SRP).Forty patients with advanced periodontitis were included. Baseline saliva samples analysed for interleukin-1β (IL-1β), matrix metalloproteinase-8 loads Porphyromonas gingivalis, Prevotella intermedia, Aggregatibacter actinomycetemcomitans Tannerella forsythia. After SRP, pocket closure further attachment loss at 6 months post-treatment chosen as...
Although cementum plays an essential role in tooth attachment and adaptation to occlusal force, the regulatory mechanisms of cementogenesis remain largely unknown. We have previously reported that Axin2-expressing (Axin2+ ) mesenchymal cells periodontal ligament (PDL) are main cell source for growth, constitutive activation Wnt/β-catenin signaling Axin2+ results hypercementosis. Therefore, aim present study was further evaluate effects β-catenin deletion on cementogenesis.We generated triple...
Background: Glycogen storage diseases (GSDs) are genetic disorders that result from defects in the processing of glycogen synthesis or breakdown within muscles, liver, and other cell types. It also manifests with impaired neutrophil chemotaxis neutropenic episodes which results severe destruction supporting dental tissues, namely periodontium. Although GSD Type Ib cannot be cured, associated symptoms debilitating oral manifestations disease can managed through collaborative medical care...
Abstract Lipoxin A4 (LXA4) has been identified as the braking signal of inflammation, but specific role LXA4 in regulating regenerative potential periodontal ligament stem cells (PDLSCs) remains unclear. The aim this study was to investigate whether and, if so, how improves osteogenic differentiation PDLSCs a lipopolysaccharide (LPS)‐induced inflammatory environment. We detected effects on vitro and explored bone LXA4‐treated vivo using calvarial critical sized defect model male rats. RNA...
Introduction: Asymptomatic displacement of dental implants into the maxillary sinus after a transcrestal augmentation is rare complication that can occur when there poor bone quality and minimal residual height. Patient compliance with postoperative appointments failure to comply denture‐wearing instructions are critical contributing factors. To best authors’ knowledge, no cases implant dislodgement attributable removable prosthesis have been reported in literature, although some studies...