A5072187328- Tendon Structure and Treatment
- Shoulder Injury and Treatment
- Orthopedic Surgery and Rehabilitation
- Knee injuries and reconstruction techniques
- Sports injuries and prevention
- Antimicrobial Resistance in Staphylococcus
- Shoulder and Clavicle Injuries
- Bacterial biofilms and quorum sensing
- Electrodeposition and Electroless Coatings
- Metal and Thin Film Mechanics
- Machine Learning in Healthcare
- Antibiotic Resistance in Bacteria
- Surface Modification and Superhydrophobicity
- Antimicrobial Peptides and Activities
- Neuroscience and Neural Engineering
- Structural Behavior of Reinforced Concrete
- SARS-CoV-2 and COVID-19 Research
- Photopolymerization techniques and applications
- COVID-19 diagnosis using AI
- High Entropy Alloys Studies
- Nerve Injury and Rehabilitation
- Structural Load-Bearing Analysis
- Polymer composites and self-healing
- Additive Manufacturing Materials and Processes
- Electrohydrodynamics and Fluid Dynamics
Central South University
2014-2024
Xiangya Hospital Central South University
2014-2024
Mayo Clinic
2019-2024
North China University of Science and Technology
2022-2023
Hunan Provincial Center for Disease Control and Prevention
2023
Shenzhen University Health Science Center
2017-2022
Soil and Fertilizer Institute of Hunan Province
2019-2022
Hebei Medical University
2022
Second Hospital of Hebei Medical University
2022
Second Xiangya Hospital of Central South University
2021
Renewable energy technologies, particularly in electric vehicles (EVs), have received significant attention recent years. The wasted a vehicle's shock absorber can be converted into an alternative source by regenerative absorbers. In this paper, high-efficiency considering twin ball screws transmissions is proposed for application range-extended vehicles. convert vibrational kinetic energy, which traditionally dissipated as heat suspension systems, electricity. system divided four modules:...
Rotator cuff (RC) attaches to humerus across a triphasic yet continuous tissue zones (bone-fibrocartilage-tendon), termed "enthesis". Regrettably, rapid and functional enthesis regeneration is challenging after RC tear. The existing grafts bioengineered for repair are insufficient, as they were engineered by scaffold that did not mimic normal in morphology, composition, tensile property, meanwhile cannot simultaneously stimulate the formation of bone-fibrocartilage-tendon tissues. Herein, an...
Background: Low-intensity pulsed ultrasound stimulation (LIPUS) has been proven to be a beneficial biophysical therapy for tendon-bone (T-B) healing. However, the optimal time initiate LIPUS treatment not determined yet. initiated at different stages of inflammatory phase may profoundly affect T-B Purpose: An established rabbit model was used preliminarily investigate effect initiation timing on Study Design: Controlled laboratory study. Methods: A total 112 mature rabbits that underwent...
Biofilm formation and hemolysis induced by Staphylococcus aureus are closely related to pathogenicity. However, no drugs exist inhibit biofilm or S. in clinical practice. This study found diclazuril had antibacterial action against with minimum inhibitory concentrations (MICs) at 50 μM for both methicillin-sensitive (MSSA) methicillin-resistant (MRSA). Diclazuril (at 1/4× 1/8× MICs) significantly inhibited of under static flow-based conditions also aureus. The RNA levels transcriptional...
Fluorescence lifetime is not only associated with the molecular structure of fluorophores, but also strongly depends on environment around them, which allows fluorescence imaging microscopy (FLIM) to be used as a tool for precise measurement cell or tissue microenvironment. This review introduces basic principle technology and its application in clinical medicine, including research diagnosis diseases skin, brain, eyes, mouth, bone, blood vessels cavity organs, drug evaluation. As...
Reducing tendon failure after repair remains a challenge due to its poor intrinsic healing ability. The purpose of this study is investigate the effect novel tissue-engineered purified exosome product (PEP) patch on in canine ex vivo model. Lacerated flexor digitorum profundus (FDP) tendons from three canines' paws underwent simulated with Tisseel alone or biopotentiated PEP. For model, FDP were randomly divided into groups: group (Control), group, and plus PEP (TEPEP) group. Following 4...
Defining the optimal rehabilitation programs for rotator cuff healing remains a challenge. Early treadmill running may have negative effects on tendon-bone interface (TBI) with increased expression of Neuropeptide Y (NPY). However, underlying mechanism is still unknown. The mice were randomly assigned to four groups: control group, + BIBO3304 group and BIBO3304 alone. Specifically, was allowed free cage activity without any treatment after surgery. received early initiated from...
Rotator cuff injuries increase with age. The enthesis is the most frequent site of rotator injury and degeneration. Understanding age-related changes are essential to determine mechanism injuries, degeneration, guide mechanistically driven therapies. In this study, we explored cellular in young, mature, aged rats. Here found that typified by an increased mineralized zone decreased nonmineralized zone. Proliferation, migration, colony-forming potential derived cells (RCECs) was attenuated...
This study was designed to evaluate the effects of low-intensity pulsed ultrasound on bone regeneration during bone–tendon junction healing process and explore application synchrotron radiation micro computed tomography in three dimensional visualization microarchitecture new trabecular bone. Twenty four mature New Zealand rabbits underwent partial patellectomy establish a injury model at patella–patellar tendon complex. Animals were then divided into treatment (20 min/day, 7 times/week)...
Tendon-bone interface (TBI) injuries are common in sports activities. Owing to the limited regenerative ability of TBI, its functional healing remains a difficulty clinical practice. Icariin (ICA) provides strong stimulation for osteogenesis. Platelet-rich plasma (PRP) can be used as carrier bioactive molecules, although provide sustained release such molecules needs improvement.Freeze-dried PRP (FD-PRP) ICA into tendon-bone (T-B) site, thus accelerating T-B healing.Controlled laboratory...
The Ni-Co/SiC composite coatings were prepared via jet electrodeposition in the presence of magnetic field. microstructure and texture orientation analyzed field emission scanning electron microscopy, three-dimensional profiling, X-ray diffraction. microhardness wear resistance characterized by a tester friction–abrasion testing machine. results indicated that nano-SiC particles improved surface morphology coating. In electrodeposition, globular structure aggregation began to form...
The decrease and functional failure of the central cholinergic neurons caused by degeneration necrosis, not only directly led to a series clinical symptoms Alzheimer's disease (AD), but also seriously affected efficacy cholinesterase inhibitors. At present, treatment AD has extremely limited effect. In this work, novel nanoparticle incorporating Nogo Receptor-siRNA (NgR-siRNA) brain derived neurotrophic factor (BDNF) was designed synthesized realize synergic with high efficiency. After...
Dysregulated cardiac function after sepsis in intensive care unit is known to predict poor long-term outcome and increase mortality. Their pathological feature molecular mechanism remain unclear. We observed that septic patients with depressed left ventricular ejection fraction (LVEF) have the highest in-hospital 28 days mortality comparing hyperdynamic LVEF or heart failure preserved LVEF. Echocardiograms reveal survivors post cecum ligation puncture (CLP) on rodents stable non-survivors...
Objective The aim of the study was to evaluate dosage effect low-intensity pulsed ultrasound stimulation on tendon-bone healing. Design Standard partial patellectomies were performed 120 mature New Zealand rabbits randomly assigned into following three groups: a control group (daily mock sonication, 20 mins), qd ultrasonication, and bid (ultrasonication twice day, mins each time). killed 8 or 16 wks postoperatively, microarchitectural, histological, mechanical properties patella-patellar...
Understanding the three-dimensional ultrastructure morphology of tendon-to-bone interface may allow development effective therapeutic interventions for enhanced healing. This study aims to assess feasibility propagation phase-contrast synchrotron radiation microtomography (PPC-SRµCT) characterization microstructure in rabbit patella–patellar tendon (PPTI). Based on phase retrieval PPC-SRµCT imaging, this technique is capable visualizing internal architecture PPTI at a cellular high spatial...
Postoperative exercise has been demonstrated to be beneficial for bone-tendon interface (BTI) healing, yet the debate regarding optimal time initiate after tendon enthesis repair is ongoing. This study aimed evaluate initiation times repair. A total of 192 C57BL/6 mice underwent acute supraspinatus injury The animals were then randomly assigned four groups: free cage activity (control group); treadmill running started on postoperative day 2 (2-day delayed 7 (7-day group), and 14 (14-day...
In order to strengthen the wear resistance of a Nickel-Polytetrafluoroethylene (Ni-PTFE) composite coating, nano-Silicon Carbide (SiC) particles and nano-PTFE were thoroughly mixed into nickel Watts plating solution. The Ni-PTFE/SiC coating was then deposited by jet magnetic electroplating compared with traditional jet-electroplated Ni, Ni-PTFE, coatings. microstructures nanoparticle distributions coatings characterized field emission scanning electron microscopy (FESEM), energy dispersive...
Low-intensity pulsed ultrasound (LIPUS) has been proven to facilitate bone-tendon interface (BTI) healing and regulate some inflammatory cytokines. However, the role of macrophages, a key type cell, during treatment remains unknown. This study aimed investigate macrophages in BTI injury with LIPUS rotator cuff tear animal model.In this experimental comparative study, total 160 C57BL/6 mature male mice that underwent supraspinatus tendon detachment repair were randomly assigned 4 groups:...