A5015393438- Tendon Structure and Treatment
- Shoulder Injury and Treatment
- Orthopedic Surgery and Rehabilitation
- Connective tissue disorders research
- Sports injuries and prevention
- Foot and Ankle Surgery
- Diabetic Foot Ulcer Assessment and Management
- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Pulmonary Hypertension Research and Treatments
- Elbow and Forearm Trauma Treatment
- Hip disorders and treatments
- Knee injuries and reconstruction techniques
- Ophthalmology and Eye Disorders
- Orthopedic Infections and Treatments
- Nerve Injury and Rehabilitation
- Connective Tissue Growth Factor Research
- Veterinary Equine Medical Research
- Spine and Intervertebral Disc Pathology
- Medical Research and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Periodontal Regeneration and Treatments
- Craniofacial Disorders and Treatments
- Musculoskeletal synovial abnormalities and treatments
- Ultrasound and Hyperthermia Applications
Central South University
2019-2024
Xiangya Hospital Central South University
2019-2024
Hunan Children's Hospital
2022-2024
Hunan Provincial People's Hospital
2024
University of South China
2022-2024
Soil and Fertilizer Institute of Hunan Province
2020-2023
National Clinical Research
2023
Nanjing Drum Tower Hospital
2015
China Medical University
2014
Tianjin Medical University
2007-2010
Background: Bone-tendon injury is characterized by poor self-healing. It established that exosomes are favorable for tissue repair and regeneration. However, their effect on bone-tendon healing has not yet been determined. Purpose: To compare the effectiveness of derived from adipose-derived mesenchymal stromal cells (ADSC-Exos) bone marrow–derived (BMSC-Exos) interface in murine rotator cuff model explore underlying mechanisms thereof. Study Design: Controlled laboratory study. Methods: A...
Abstract Periosteal stem cells are critical for bone regeneration, while the numbers will decrease with age. This study focused on whether Prx1 + cell, a kind of periosteal could stimulate regeneration in aged mice. Four weeks and 12 months old Prx1CreER‐GFP; Rosa26 tdTomato mice were used to reveal degree participating femoral fracture healing procedure. One week, 8 weeks, 24 Prx1CreER‐GFP analyse real‐time distribution cells. Twelve C57BL/6 male (n = 96) create defect model and,...
Proper mechanical stimulation can improve rotator cuff enthesis injury repair. However, the underlying mechanism of promoting repair is still unknown. In this study, we found that Prrx1 + cell was essential for murine development identified by single-cell RNA sequence and involved in could promote migration cells to enhance Meantime, TGF-β signaling primary cilia played an role mediating transmission. enhanced release active TGF-β1 cells. Inhibition eliminated stimulatory effect on addition,...
It has been established that mechanical stimulation benefits tendon-bone (T-B) healing, and macrophage phenotype can be regulated by cues; moreover, the interaction between macrophages mesenchymal stem cells (MSCs) plays a fundamental role in tissue repair. This study aimed to investigate of macrophage-mediated MSC chondrogenesis load-induced T-B healing depth. C57BL/6 mice rotator cuff (RC) repair model was explore effects on polarization, transforming growth factor (TGF)-β1 generation,...
Abstract Postoperative exercise has been found able to accelerate bone‐tendon (B‐T) healing. In this study, we systematically compared tendon‐to‐bone healing in mice subjected postoperative treadmill and free cage recovery a murine rotator cuff repair model. Specifically, C57BL/6 underwent unilateral supraspinatus tendon (SST) detachment were randomly allocated into group control group. Treadmill received daily running initiated from day 7 while the was allowed activity. Mice euthanized at 4...
Injuries at the bone-tendon interface (BTI) are common findings in clinical practice. Rehabilitation procedures after BTI surgery important but controversial.To investigate effects of different exercise intensities on healing by means an established mouse rotator cuff injury model.Controlled laboratory study.A total 150 specific pathogen free male C57BL/6 mice, with supraspinatus insertion injury, were randomly assigned to 1 5 groups according postoperative rehabilitation intensities: (1)...
It is challenging to create an ideal artificial acetabulum during total hip arthroplasty (THA) in adult DDH. Our team developed a new patient-specific instrument (PSI) that uses the superolateral rim of as positioning mark assist production Crowe II/III DDH patients. The purpose this retrospective study verify whether PSI can be used implement preoperative plan accurately and quickly THA We selected suitable patients from registration system for joint surgery at our hospital April 2016 March...
Achilles tendon (AT) defects often occur in traumatic and chronic injuries. Currently, no graft can satisfactorily regenerate parallel tendinous tissue at the defect site to completely restore AT function.To develop a cell-free functional by tethering bone morphogenetic protein 12 (BMP-12) on book-shaped decellularized matrix (BDTM) determine whether this is more beneficial for healing than an autograft.Controlled laboratory study.Canine patellar was sectioned into book shape fabricate BDTM....
The microstructure of the bone-tendon interface (BTI) deserves in-depth investigation. In this study, we first aimed to extend application synchrotron radiation μCT characterize gradient structure supraspinatus tendon (SST) enthesis, from both tissue morphology cell distribution. Second, acquire detailed morphological information SST enthesis when after injury. Our results showed that in normal phenotype chondrocyte BTI was dependent on its distance subchondral bone. After injury,...
Abstract Background A simulation and model (SM) teaching aid using 3D printing was developed to improve a training course for total hip arthroplasty of adult developmental dysplasia the (adult DDH-THA). We named this new method Surgery Simulation Teaching based on Real Reconstruction Aid (RRA-SST). prospective randomized comparison performed with traditional surgical live evaluate effectiveness RRA-SST DDH-THA. Methods Twenty-six trainees, who were already practicing but not experienced,...
The attachment site of the rotator cuff (RC) is a classic fibrocartilaginous enthesis, which junction between bone and tendon with typical characteristics fibrocartilage transition zone. Enthesis development has historically been studied lineage tracing individual genes selected priori, does not allow for determination single-cell landscapes yielding mature cell types tissues. Here, in together open-source GSE182997 datasets (three samples) provided by Fang et al., we applied Single-cell RNA...
Postoperative exercise has been demonstrated to be beneficial for bone-tendon interface (BTI) healing, yet the debate regarding optimal time initiate after tendon enthesis repair is ongoing. This study aimed evaluate initiation times repair. A total of 192 C57BL/6 mice underwent acute supraspinatus injury The animals were then randomly assigned four groups: free cage activity (control group); treadmill running started on postoperative day 2 (2-day delayed 7 (7-day group), and 14 (14-day...
How to improve rotator cuff healing remains a challenge. Little is known about the effect of parasympathetic transmitter acetylcholine (ACh) and acetylcholinesterase inhibitor pyridostigmine (PYR), both which have anti-inflammatory properties, in process injury.ACh PYR could enhance bone-tendon interface murine model repair.Controlled laboratory study.A total 160 C57BL/6 mice underwent unilateral repair surgery. Fibrin gel (FG) was used as drug carrier. The were randomly assigned 4 groups...
Abstract Background Traditional methods for minimally invasive internal fixation (MIIF) of calcaneal fractures require extensive intraoperative fluoroscopy, and fracture recovery is usually not ideal. We developed a new surgical procedure using digital simulation constructed patient-specific instrument (PSI) that we used during the operation. This study investigated whether PSI-assisted MIIF enables rapid accurate execution preoperative plan. Methods retrospectively analyzed patients with...
<title>Abstract</title> <bold>Background: </bold>Hereditary Multiple Osteochondroma (HMO) is a rare condition that frequently impacts the forearm and results in radial head dislocation. Consequently, orthopedic surgeons prioritize prognostication of factors contributing to dislocation implementing preventive measures. The purpose this study was introduce specific type HMO prone provide potential therapeutic strategies for clinical prevention. We retrospectively reviewed patients with treated...
Abstract Background Bone-tendon interface (BTI) is a typical fibrocartilaginous insertion consisting of continuous yet functionally graded structure. However, the underlying mechanism enthesis formation poorly understood. It was reported that primary cilia sense changes in microenvironment BTI undergoing mechanical stimulation to regulate repairing. The objective this study investigate how mediate formation. Methods Mice at different ages were used for tracing spatiotemporal distribution...
Количественная ПЦР в реальном времени становится рутинным методом изучения экспрессии генов. Однако экспрессию генов масличной камелии невозможно точно анализировать количественно из-за отсутствия подходящих референсных С целью обнаружения стабильно экспрессирующихся нами собраны образцы разных тканей (в том числе корней, стеблей, листьев, цветков и семян) шести видов камелии. Из базы данных секвенированных РНК (RNA-seq) семян Camellia oleifera С.Abel отобрали нуклеотидные последовательности...