A5048152613- Advanced MRI Techniques and Applications
- EEG and Brain-Computer Interfaces
- Sleep and Wakefulness Research
- Neural dynamics and brain function
- Electrical and Bioimpedance Tomography
- Functional Brain Connectivity Studies
- Atomic and Subatomic Physics Research
- Advanced Neuroimaging Techniques and Applications
- Microwave Imaging and Scattering Analysis
- Tendon Structure and Treatment
- Corrosion Behavior and Inhibition
- Organ Transplantation Techniques and Outcomes
- Neuroscience of respiration and sleep
- Traumatic Brain Injury and Neurovascular Disturbances
- Renal Transplantation Outcomes and Treatments
- Sleep and related disorders
- Ferroptosis and cancer prognosis
- NMR spectroscopy and applications
- Geological and Geochemical Analysis
- Sports injuries and prevention
- Concrete Corrosion and Durability
- Anodic Oxide Films and Nanostructures
- Hydrogen Storage and Materials
- FOXO transcription factor regulation
- Bone Metabolism and Diseases
National Institute of Neurological Disorders and Stroke
2020-2025
National Institutes of Health
2020-2025
Beijing Chao-Yang Hospital
2020-2025
Capital Medical University
2020-2025
Stony Brook University
2024
Wuhan Institute of Technology
2023-2024
Mayo Clinic in Arizona
2024
Hebei GEO University
2024
Second Affiliated Hospital of Jilin University
2022
Shandong Institute for Product Quality Inspection
2021
During sleep, slow waves of neuro-electrical activity engulf the human brain and aid in consolidation memories. Recent research suggests that these may also promote health by facilitating removal metabolic waste, possibly orchestrating pulsatile flow cerebrospinal fluid (CSF) through local neural control over vascular tone. To investigate role generation CSF pulsations, we analyzed functional MRI data obtained across full sleep-wake cycle during a waking respiratory task. This revealed novel...
The purpose is to provide a comprehensive review of the electrical properties tomography (EPT) technique, which was introduced image (EPs) tissue noninvasively by exploiting measured field data MRI.
Cerebrospinal fluid (CSF) provides physical protection to the central nervous system as well an essential homeostatic environment for normal functioning of neurons. Additionally, it has been proposed that pulsatile movement CSF may assist in glymphatic clearance brain metabolic waste products implicated neurodegeneration. In awake humans, flow dynamics are thought be driven primarily by cerebral blood volume fluctuations resulting from a number mechanisms, including passive vascular response...
Tissue longitudinal relaxation characterized by recovery time T1 or rate R1 is a fundamental MRI contrast mechanism that increasingly being used to study the brain's myelination patterns in both health and disease. Nevertheless, quantitative relationship between myelination, its dependence on B0 field strength, still not well known. It has been theorized much of brain tissue, field-dependence driven macromolecular protons (MP) through called magnetization transfer (MT). Despite explanatory...
Reducing tendon failure after repair remains a challenge due to its poor intrinsic healing ability. The purpose of this study is investigate the effect novel tissue-engineered purified exosome product (PEP) patch on in canine ex vivo model. Lacerated flexor digitorum profundus (FDP) tendons from three canines' paws underwent simulated with Tisseel alone or biopotentiated PEP. For model, FDP were randomly divided into groups: group (Control), group, and plus PEP (TEPEP) group. Following 4...
Background: Epidemiological associations between kidney stone disease (KSD) and gastrointestinal disorders have been reported, intestinal homeostasis plays a critical role in formation. However, the underlying intrinsic link is not adequately understood. This study aims to investigate genetic these two types of diseases. Methods We obtained summary statistics from large-scale genome-wide association studies KSD diseases, including gastroesophageal reflux (GERD), peptic ulcer disease,...
Abstract Purpose To demonstrate further acceleration of spin echo MRI by combining the simultaneous multi‐slice approach with recently introduced patterned multislice excitation (PME) technique and evaluate application for rapid diffusion‐weighted MRI. Theory Methods Implementation at 3T involved design RF pulses simultaneously acting on four separate slices within hardware limits peak amplitude. This was accomplished time‐shifted sub‐pulses a dedicated switching scheme slice‐select...
To develop and evaluate a technique for imaging electrical properties ((EPs), conductivity permittivity) of an animal tumor model in vivo using MRI.Electrical were reconstructed from the calculated EP gradient, which was derived two sets measured transmit B1 magnitude relative phase maps with sample radiofrequency (RF) coil oriented positive negative z-directions, respectively. An eight-channel transceiver microstrip array RF fitting size developed generating mapping fields to reconstruct...
Purposes To develop and evaluate a boundary informed electrical properties tomography (BIEPT) technique for high‐resolution imaging of tumor (EPs) heterogeneity on rodent xenograft model. Methods Tumor EP distributions were inferred from reference area external to the tumor, as well internal spatial variations derived plurality relative transmit B 1 measurements at 7T. Edge sparsity constraint was enforced enhance numerical stability. Phantom experiments performed determine accuracy...
Abstract Purpose This study aimed to compare the prognostic value of multiple lymph node metastasis (LNM) indicators and develop optimal nomograms for bladder cancer (BC) patients. Methods BC patients were obtained from Surveillance, Epidemiology, End Results (SEER) database between 2004 2015, randomly partitioned into training internal validation cohorts. Genomic clinical data collected The Cancer Genome Atlas (TCGA) as external cohort. predictive efficiency LNM was compared by constructing...
Prevention of adhesion formation following flexor tendon repair is essential for restoration normal finger function. Although many medications have been studied in the experimental setting to prevent adhesions, clinical application limited due complexity and delivery translation. In this study, optimal dosages gelatin pentamidine were validated by concentration test. Following cell viability, migration, live dead cell, assay Turkey tenocytes, a model was established evaluate effectiveness...
Understanding the function of sleep requires studying dynamics brain activity across whole-night and their transitions. However, current gold standard polysomnography (PSG) has limited spatial resolution to track activity. Additionally, previous fMRI studies were too short capture full stages cycling. To study whole-brain transitions sleep, we used an unsupervised learning approach, Hidden Markov model (HMM), on two-night, 16 hr recordings 12 non-sleep-deprived participants who reached all...
Clear cell renal carcinoma (ccRCC) is the most prevalent malignancy in adults with generally poor prognosis. This study aimed to establish a DNA methylation-driven gene-based prognostic model for ccRCC. We collected methylation and gene expression profiles of over 1500 ccRCC samples from The Cancer Genome Atlas (TCGA) dataset, four Gene Expression Omnibus (GEO) datasets, Genotype-Tissue (GTEx) cancer lines Cell Line Encyclopedia database performed comprehensive bioinformatics analysis. As...
Electrical conductivity and permittivity of biological tissues are important diagnostic parameters useful for calculating subject-specific specific absorption rate distribution. On the other hand, water proton density also has clinical relevance diagnosis purposes. These two kinds tissue properties inevitably associated in technique electrical tomography (EPT), which can be used to map vivo based on measured B1 field distribution at Larmor frequency using magnetic resonance imaging (MRI)....
In magnetic resonance-based electrical properties tomography (EPT), circularly polarized field B <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> from a transmit radiofrequency (RF) coil is measured and utilized to infer the conductivity permittivity of biological tissues. Compared with quadrature RF coil, multi-channel provides plurality unique patterns that help alleviate under-determinedness EPT reconstruction problem, it also allows...
The increased availability of ultra-high field scanners provides an opportunity to perform fMRI at sub-millimeter spatial scales and enables in vivo probing laminar function the human brain. In most previous studies, definition cortical layers, or depths, is based on anatomical reference image that collected by a different acquisition sequence exhibits geometric distortion compared functional images. Here, we propose generate with technique incorporating magnetization transfer (MT) weighted...
Understanding the function of sleep requires studying dynamics brain activity across whole-night and their transitions. However, current gold standard polysomnography (PSG) has limited spatial resolution to track activity. Additionally, previous fMRI studies were too short capture full stages cycling. To study whole-brain transitions sleep, we used an unsupervised learning approach, Hidden Markov model (HMM), on two-night, 16-hour recordings 12 non-sleep-deprived participants who reached all...
Background/Aims: Diabetic fracture have poor treatment and serious complications. Therefore, how to treat diabetic is receiving increasing attention. This study aimed investigate the effects of transplanting CXCL13-stimulated bone marrow stromal cells (BMSCs) on healing in rats. Methods: In vitro, RT-PCR was employed examine expression CXCL13 BMSCs high glucose environment. MTT assay apoptosis were utilized determine overexpression proliferation respectively. ALP staining applied detect...
Obesity and osteoporosis are two of the most common chronic disorders with high prevalence rates, literature reports contradictory results when considering relationship between body mass index (BMI)/obesity bone metabolism. Although several arguments support a key role played by adipose tissue in this process, exact mechanism remains poorly understood. First, pattern regional fat deposition into subcutaneous visceral compartments is suggested as stronger predictor risk than overall mass....