A5022105113- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Breast Cancer Treatment Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Treatment and Pharmacology
- Microtubule and mitosis dynamics
- Neutropenia and Cancer Infections
- Liver physiology and pathology
- Bone health and treatments
- Breast Lesions and Carcinomas
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- Retinal Diseases and Treatments
- Cancer Diagnosis and Treatment
- Cancer Cells and Metastasis
- Estrogen and related hormone effects
- Cancer, Lipids, and Metabolism
- Sleep and related disorders
- Frailty in Older Adults
- Tannin, Tannase and Anticancer Activities
- Erythropoietin and Anemia Treatment
- Nutrition, Genetics, and Disease
- Protein Degradation and Inhibitors
China Pharmaceutical University
2025
Fudan University
2024
Zhongshan Hospital
2024
Shandong Agricultural University
2024
Wenzhou Medical University
2024
University of Electronic Science and Technology of China
2023
Xiangya Hospital Central South University
2023
Central South University
2023
Sichuan Cancer Hospital
2023
Jiaxing University
2021
ObjectiveA recent suggestion is that the predictive value of a single biomarker may rely on genetic background tumor and different breast cancer subgroups have markers response to chemotherapy. The prognostic p53 in outcome adjuvant anthracycline-containing chemotherapy was evaluated according molecular subclasses defined using expression estrogen receptor, progesterone receptor human epidermal growth factor 2.
To assess the safety and efficacy of local ablation plus PD-1 inhibitor toripalimab in previously treated unresectable hepatocellular carcinoma (HCC).In multicenter, two-stage, randomized phase 1/2 trial, patients were randomly assigned to receive alone (240 mg, every 3 weeks), subtotal followed by starting on post-ablation day (Schedule D3), or 14 D14). The first endpoint stage 1 was determine which combination schedule could continue progression-free survival (PFS) as primary for 1/2.A...
Molecular glue degraders induce "undruggable" protein degradation by a proximity-induced effect. Inspired the clinical success of immunomodulatory drugs, we aimed to design novel molecular targeting GSPT1. Here, report series GSPT1 degraders. LYG-409, 2H-chromene derivative, was identified as potent, selective, and orally bioavailable degrader with excellent antitumor activity in vivo (anti-Acute Myeloid Leukemia MV4–11 xenograft model: TGI = 94.34% at 30 mg/kg; prostate cancer 22Rv1 104.49%...
The status of axillary lymph nodes (ALNs) is the most important prognostic factor in breast cancer. purpose this study was to evaluate clinical usefulness ALN involvement by means positron emission tomography-computed tomography (PET-CT) compared with sonography and mammography patients early This involved 108 cancer non-palpable ALNs. All had PET-CT, imaging before sentinel node (SLN) biopsy. After SLN biopsy, all underwent complete dissection. ALNs were evaluated standard hematoxylin eosin...
This study aimed to investigate the association of whole body/regional fat mass (FM) with cardiometabolic disease (CMD) trajectory.
Age is one of the important prognostic factors in thyroid cancer, and old age generally related to higher rate post-operative morbidity mortality. The study analyzed characteristics cancer elderly patients compared with those younger patients.Patients who underwent surgery between 1992 2011 were enrolled. divided into ≥70 years (older group) <70 (younger group). Data including clinicopathological features complications was analyzed. Molecular markers Galectin-3, Cyclooxygenase-2, bcl-2,...
<p>Supplementary Method, Table 1-9</p>
<p>Supplementary Fig. 4 A. Progression-free survival by PD-L1 status. B. Overall Dot marks indicate censored data.</p>
<p>Supplementary Fig. 3 A. Progression-free survival by CD8+ TIL density. B. Overall Dot marks indicate censored data.</p>
<p>Supplementary Fig. 1 Forest plot of subgroup analysis for progression-free survival (A) and overall (B).</p>
<p>Supplementary Fig. 2 The association of CD8+ TIL density and PD-L1 expression with tumor objective response.</p>
<div>Abstract<p>Purpose: To assess the safety and efficacy of local ablation plus PD-1 inhibitor toripalimab in previously treated unresectable hepatocellular carcinoma (HCC). Patients Methods: In multicenter, two-stage, randomized phase 1/2 trial, patients were randomly assigned to receive alone (240mg, every 3 weeks), subtotal followed by starting on post-ablation day (Schedule D3) or 14 D14). The first endpoint stage 1 was determine which combination schedule could continue...
<p>Supplementary Method, Table 1-9</p>
<p>Supplementary Fig. 1 Forest plot of subgroup analysis for progression-free survival (A) and overall (B).</p>
<p>Supplementary Fig. 2 The association of CD8+ TIL density and PD-L1 expression with tumor objective response.</p>
<p>Supplementary Fig. 3 A. Progression-free survival by CD8+ TIL density. B. Overall Dot marks indicate censored data.</p>
<p>Supplementary Fig. 4 A. Progression-free survival by PD-L1 status. B. Overall Dot marks indicate censored data.</p>
Acute myeloid leukemia (AML), a malignant clonal disease originating from hematopoietic stem cells. In the past few decades, AML treatment has been dominated by "3+7" regimen (anthracyclines + cytarabine), and survival curve stagnated. However, these procedures are associated with serious adverse effects. The development of chimeric antigen receptor (CAR)-T cell provides viable alternative, decreased non-relapse death rates. Despite its potential, CAR-T therapy for confronts significant...
Surfeit locus protein 4 (SURF4) acts as a cargo receptor to mediate endoplasmic reticulum export of various cargos. We have shown that SURF4 is essential for secretion hepatic very low-density lipoprotein and intestinal chylomicron. Knockdown Surf4 also significantly reduces the development atherosclerosis liver fibrosis without causing overt damage. However, constitutive global knockout results in embryonic lethality. To further understand physiological role SURF4, we generated...
Frailty is an emerging global health burden, and there no consensus on the precise prediction of frailty. We aimed to explore association between grip strength frailty interpret optimal machine learning (ML) model using SHapley Additive exPlanation (SHAP) predict risk
621 Background: Oral corticosteroids are known to be given for three days the patients having TAC (docetaxel, doxorubicin and cyclophosphamide) chemotherapy in node-positive breast cancer prevent severe fluid retension. But most have been complaining of much weight gain after use more than 10 kilograms. We tried determine whether 24-hour corticosteroid medication (8 mg, bid) is adequate enough retension, instead using full three-day premedications. Methods: Between Jan. 2006 Oct. 2007, 80...
e11552 Background: Despite of its proven therapeutic efficacy, TAC (docetaxel, Doxorubicin and cyclophosphamide) regimen as an adjuvant chemotherapy has some serious adverse effects such fluid retention neutropenia. Even though dexamethasone is known to be given for three days the patients having prevent severe retention, most have ironically been complaining much weight gain more than 15% increase after use dexamethasone. We tried determine abbreviated better decrease extent chemotherapy....
613 Background: TAC (docetaxel, doxorubicin and cyclophosphamide) chemotherapy has been accepted as an adjuvant for the node positive breast cancer. But, moderate to severe adverse reactions, especially neutropenia, right after this regimen have major hurdle wider enthusiasm. Until now, ciprofloxacin given patients on completion of each cycle prevent systemic infection. We tried determine if is be included in post-chemotherapy medications or not stop possible Methods: randomly assigned 100...