A5056887540- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- BRCA gene mutations in cancer
- Cancer Risks and Factors
- Maternal Mental Health During Pregnancy and Postpartum
- Vitamin D Research Studies
- COVID-19 Impact on Reproduction
- Pancreatic function and diabetes
- Child and Adolescent Psychosocial and Emotional Development
- Nutrition, Genetics, and Disease
- Rheumatoid Arthritis Research and Therapies
- Early Childhood Education and Development
- Family Support in Illness
- Hepatitis C virus research
- CRISPR and Genetic Engineering
- Child Nutrition and Feeding Issues
- Folate and B Vitamins Research
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Protein Hydrolysis and Bioactive Peptides
- Chronic Lymphocytic Leukemia Research
- Fatty Acid Research and Health
- Grief, Bereavement, and Mental Health
- Infant Nutrition and Health
University of Cambridge
2023-2025
University of Alberta
2024
University of Toronto
2020-2023
Mount Sinai Hospital
2022
Western University
2019
BACKGROUNDThe COVID-19 pandemic presents unique social, economic, and psychological challenges for individuals globally. Thus, women who are pregnant face unprecedented mental health challenges.OBJECTIVEWe sought to determine the impact of on perinatal depression anxiety in a longitudinal pregnancy cohort. We hypothesized increased scores during after birth at all time points.STUDY DESIGNParticipants were enrolled Ontario Birth Study, cohort embedded clinical care Mount Sinai Hospital,...
Season of birth/conception has been used to study neurodevelopmental risk in hundreds studies, however the translational impact this work remains limited. We propose a new model season-of- conception effects on neurodevelopment using maternal fall-winter seasonality as key moderating variable, and provide initial empirical data support approach. In an ongoing pregnancy cohort we evaluated associations between season-of history Seasonal Affective Disorder (SAD) child executive functioning 520...
Background: Obesity during pregnancy is related to adverse maternal and neonatal outcomes. Factors involved in these outcomes may include increased insulin resistance, inflammation, oxidative stress, nutrient mishandling. The placenta the primary determinant of fetal outcomes, its function can be impacted by obesity. aim this study on mice was determine effect obesity lipid handling, inflammatory redox state, placental signaling, gene expression relative female male growth. Methods: Female...
Recent advances have significantly expanded our understanding of the gut microbiome's influence on host physiology and metabolism. However, specific role certain microorganisms in gestational health fetal development remains underexplored.
The role of vitamin D and calcium use in the development breast cancer among women general population is not clear. Furthermore, whether supplement are associated with high-risk populations has been evaluated. Thus, we evaluated association between and/or a pathogenic variant (mutation) BRCA1 or BRCA2. BRCA mutation carriers enrolled longitudinal study were invited to complete supplemental questionnaire on lifetime use. Cases included prevalent diagnosis invasive cancer, controls had no...
Surfeit locus protein 4 (SURF4) acts as a cargo receptor to mediate endoplasmic reticulum export of various cargos. We have shown that SURF4 is essential for secretion hepatic very low-density lipoprotein and intestinal chylomicron. Knockdown Surf4 also significantly reduces the development atherosclerosis liver fibrosis without causing overt damage. However, constitutive global knockout results in embryonic lethality. To further understand physiological role SURF4, we generated...
Abstract Introduction Obesity during pregnancy is related to adverse maternal and neonatal outcomes. Factors involved in these outcomes may include increased insulin resistance, inflammation, oxidative stress nutrient mishandling. The placenta the primary determinant of fetal outcomes, its function can be impacted by obesity. aim this study mice was determine effect obesity on lipid handling, inflammatory redox state, placental stress, signaling, gene expression relative female male growth....
Rheumatoid Arthritis (RA) is an autoimmune disease that causes joint and bone damage through inflammation. This chronic condition often linked to genetic environmental factors. With advancements in the field of epigenetics, increased speculation has arisen understand impact DNA methylation, microRNAs, histone modifications on progression RA. Studies have indicated dysregulation epigenetics significantly contributes pro-inflammatory landscape Furthermore, separate lines evidence shown altered...
Abstract Background: Use of vitamin D and calcium-containing supplements are associated with a decreased risk breast cancer among women in the general population. Whether this association exists at high-risk due to BRCA1 or BRCA2 mutation is not known. Thus, we conducted case-control study evaluate between and/or calcium supplement use BRCA carriers. Methods: carriers enrolled longitudinal study, that collected information on history lifestyle factors, were invited complete supplemental...
Objective: The COVID-19 pandemic presents unique mental health challenges for women during pregnancy. We sought to determine its impact on maternal depression and anxiety the perinatal postpartum periods.Methods: Participants were enrolled in Ontario Birth Study, an open longitudinal pregnancy cohort. Depression was assessed using patient questionnaire early Edinburgh postnatal scale late postpartum. Anxiety generalized disorder at all periods. Logistic regression models created examine...