A5087749880- BRCA gene mutations in cancer
- Ovarian cancer diagnosis and treatment
- Nutrition, Genetics, and Disease
- Cancer Risks and Factors
- Cancer Genomics and Diagnostics
- Bone Metabolism and Diseases
- Genetic factors in colorectal cancer
- Folate and B Vitamins Research
- Heavy Metal Exposure and Toxicity
- DNA Repair Mechanisms
- Endometrial and Cervical Cancer Treatments
- Ovarian function and disorders
- Reproductive Biology and Fertility
- RNA modifications and cancer
- Health, Environment, Cognitive Aging
- Bone health and treatments
- Biomarkers in Disease Mechanisms
- Trace Elements in Health
- Heat shock proteins research
- Cytokine Signaling Pathways and Interactions
- Estrogen and related hormone effects
- Cancer-related Molecular Pathways
- Genomic variations and chromosomal abnormalities
- Selenium in Biological Systems
- CRISPR and Genetic Engineering
Public Health Ontario
2016-2025
University of Toronto
2016-2025
Women's College Hospital
2016-2025
Karolinska Institutet
2017
Medical University of Vienna
2017
Canada Research Chairs
2016
3M (United States)
2010-2015
Regional Cancer Center
2012
Sunnybrook Health Science Centre
2012
Pomeranian Medical University
2012
Background: Whether oophorectomy reduces breast cancer risk among BRCA mutation carriers is a matter of debate. We undertook prospective analysis bilateral and in carriers. Methods: Subjects had no history cancer, both breasts intact, information on status (n = 3722). Women were followed until diagnosis, prophylactic mastectomy, or death. A Cox regression model was used to estimate the hazard ratios (HRs) 95% confidence intervals (CIs) associated with (coded as time-dependent variable). All...
Magnetic resonance imaging (MRI) surveillance is offered to women with a pathogenic variant in the BRCA1 or BRCA2 gene who face high lifetime risk of breast cancer. Surveillance MRI effective downstaging cancers, but association mortality has not been well defined.
Prophylactic bilateral salpingo-oophorectomy is recommended for BRCA1 mutation carriers to prevent ovarian cancer. Whether or not hormone replacement therapy (HRT) initiated after oophorectomy associated with an increased risk of breast cancer has been evaluated in a prospective study.To determine the association between HRT use and BRCA1-associated cancer.A prospective, longitudinal cohort study BRCA2 from 80 participating centers 17 countries was conducted 1995 2017 mean follow-up 7.6...
Abstract BACKGROUND: Circulating estrogens and androgens are important factors in the development of various female cancers. Caffeine intake may decrease risk breast ovarian cancer, although data not entirely consistent. Whether or caffeine affects cancer by altering sex hormone levels is currently unknown. METHODS: We examined relationship caffeine, coffee, decaffeinated tea with plasma concentrations estrogens, androgens, progesterone, prolactin, hormone–binding globulin (SHBG) 524...
Abstract Introduction Breastfeeding has been inversely related to breast cancer risk in the general population. Clarifying role of breastfeeding among women with a BRCA1 or BRCA2 mutation may be helpful for assessment and recommendations regarding prevention. We present an updated analysis using large matched sample BRCA carriers. Methods conducted case-control study 1,665 pairs deleterious either ( n = 1,243 pairs) 422 pairs). Breast cases unaffected controls were on year birth, status,...
<h3>Importance</h3> Individuals with cancer often have an elevated platelet count at the time of diagnosis. The extent to which is indicator unclear. <h3>Objective</h3> To evaluate association a <h3>Design, Setting, and Participants</h3> This nested case-control study included Ontario residents enrolled in provincial health insurance plan who had 1 or more routine complete blood (CBC) tests performed between January 1, 2007, December 31, 2017, follow-up through 2018. Case patients were...
Abstract Background Several anthropometric measures have been found to be associated with the risk of breast cancer. Current weight, body mass index, and adult weight gain appear predictors postmenopausal These factors a reduced premenopausal We asked whether there is an association between changes in cancer women who carry mutation either susceptibility gene, BRCA1 or BRCA2 . Methods A matched case–control study was conducted 1,073 pairs carrying deleterious ( n = 797 pairs) 276 pairs)....
Abstract Background: Temporal variability of biomarkers should be evaluated before their use in epidemiologic studies. Methods: We the reproducibility, using intraclass correlation coefficients (ICC), 27 plasma, 50 red blood cell, and 9 urinary over 1 to 3 years among premenopausal (n = 40) postmenopausal 35-70) participants from Nurses' Health Study II. Results: Plasma stress hormones melatonin were measured women, whereas remaining women. ICCs good excellent for plasma carotenoids...
Abstract Introduction Ductal and lobular carcinomas are the two most common types of invasive breast cancer. Whether well-established risk factors differentially associated with on basis histologic subtype is not clear. We prospectively investigated association between a number hormonal nonhormonal exposures defined by among 4,655 ductal 659 cases postmenopausal cancer from Nurses' Health Study. Methods Multivariate Cox proportional hazards regression stratified time period was used to...
Various epidemiologic factors have been shown to influence the risk of ovarian cancer development. Given high fatality associated with this disease, it is interest evaluate association prediagnostic hormonal, reproductive, and lifestyle exposures cancer-specific survival. We included 1421 patients invasive epithelial diagnosed in Ontario, Canada. Clinical information was obtained from medical records exposure collected by telephone interview. Survival status determined linkage Ontario Cancer...
Thrombocytosis is associated with cancer progression and death for many types. It unclear if platelet count also survival. We conducted a cohort study of 112,231 adults in Ontario diagnosis between January 2007 December 2016. included patients who had complete blood (CBC) completed the 30 days prior to their diagnosis. Subjects were assigned one three categories according count: low (≤25th percentile), medium (>25 <75th high (≥75th percentile). Study subjects followed from date...
Abstract Women at high inherited risk of ovarian cancer are offered risk‐reducing salpingo‐oophorectomy (RRSO) from age 35 to 45 years. Although potentially life‐saving, RRSO may induce symptoms that negatively affect quality life and impair long‐term health. Clinical care following is often suboptimal. This scoping review describes how affects short‐ health provides evidence‐based international consensus recommendations for preoperative counselling disease prevention. includes the efficacy...
Ovarian cancer has a high case fatality rate, but patients who have no visible residual disease after surgery relatively good prognosis. The presence of any cells left in the peritoneal cavity treatment may precipitate recurrence. In many cases, these are occult and not to surgeon. Analysis circulating tumour DNA blood (ctDNA) offer sensitive method predict (non-visible) help We assessed 48 women diagnosed with serous ovarian (47 high-grade 1 low-grade) for ctDNA. Plasma, formalin-fixed...
The role of the lifetime number ovulatory cycles has not been evaluated in context BRCA-associated ovarian cancer. Thus, we conducted a matched case-control study to evaluate relationship between cumulative (and contributing components) and risk developing cancer BRCA mutation carriers (1,329 cases 5,267 controls). Information regarding reproductive hormonal factors was collected from routinely administered questionnaire. Conditional logistic regression used all associations. We observed 45%...