A5028807967- BRCA gene mutations in cancer
- Breast Cancer Treatment Studies
- Nutrition, Genetics, and Disease
- Global Cancer Incidence and Screening
- Ovarian cancer diagnosis and treatment
- Cancer Risks and Factors
- Breast Lesions and Carcinomas
- Inflammatory Biomarkers in Disease Prognosis
- Dysphagia Assessment and Management
- Machine Learning in Healthcare
- Cardiovascular Disease and Adiposity
- Bone health and treatments
- Pharmaceutical Practices and Patient Outcomes
- Colorectal Cancer Screening and Detection
- Emergency and Acute Care Studies
- Breast Implant and Reconstruction
- Metabolism, Diabetes, and Cancer
- Autopsy Techniques and Outcomes
- COVID-19 and healthcare impacts
- Health Systems, Economic Evaluations, Quality of Life
- COVID-19 Clinical Research Studies
- Gestational Diabetes Research and Management
- PARP inhibition in cancer therapy
- COVID-19 epidemiological studies
- Cancer, Lipids, and Metabolism
Women's College Hospital
2016-2025
Public Health Ontario
2015-2024
University of Toronto
2015-2024
Institute for Clinical Evaluative Sciences
2016-2024
Holland Bloorview Kids Rehabilitation Hospital
2024
Women's Hospital
2024
St. Michael's Hospital
2015-2021
Centre for Global Health Research
2015-2021
Sunnybrook Health Science Centre
2017
Health Sciences Centre
2017
Women with ductal carcinoma in situ (DCIS), or stage 0 breast cancer, often experience a second primary cancer (DCIS invasive), and some ultimately die of cancer.To estimate the 10- 20-year mortality from following diagnosis DCIS to establish whether rate is influenced by age at diagnosis, ethnicity, initial treatment received.Observational study women who received 1988 2011 Surveillance, Epidemiology, End Results (SEER) 18 registries database. Age race/ethnicity, pathologic features, date...
Guidelines advocate screening all acute stroke patients for dysphagia. However, limited data are available regarding how many and which screened failing a swallowing screen affects patient outcomes. We sought to evaluate predictors of receiving dysphagia after ischemic outcomes test.We used the Ontario Stroke Registry from April 1, 2010, March 31, 2013, identify hospitalized with determine documented test, including pneumonia, disability, death.Among 7171 patients, 6677 were eligible receive...
Increasing numbers of women experience pregnancy around the time of, or after, a diagnosis breast cancer. Understanding effect on survival in with cancer will help counseling and treatment these women.To compare overall diagnosed during postpartum period that who had but did not become pregnant.This population-based, retrospective cohort study linked health administrative databases Ontario, Canada, comprising 7553 aged 20 to 45 years at invasive cancer, from January 1, 2003, December 31,...
Calcium channel blockers (CCBs) are commonly prescribed agents for hypertension that can cause peripheral edema. A prescribing cascade occurs when the edema is misinterpreted as a new medical condition and diuretic subsequently to treat The extent which this at population level not well understood.To measure association between being newly dispensed CCB subsequent dispensing of loop in older adults with hypertension.A population-based cohort study was performed using linked health...
<h3>Importance</h3> Individuals with cancer often have an elevated platelet count at the time of diagnosis. The extent to which is indicator unclear. <h3>Objective</h3> To evaluate association a <h3>Design, Setting, and Participants</h3> This nested case-control study included Ontario residents enrolled in provincial health insurance plan who had 1 or more routine complete blood (CBC) tests performed between January 1, 2007, December 31, 2017, follow-up through 2018. Case patients were...
<h3>Importance</h3> It is not clear to what extent a diagnosis of ductal carcinoma in situ (DCIS) impacts woman's lifetime risk dying breast cancer. Under ideal circumstances, treatment will eliminate the invasive ipsilateral recurrence and prevent subsequent mortality from The cancer after DCIS had been compared with that women without general population. <h3>Objective</h3> To determine death large cohort patients treated for compare <h3>Design, Setting, Participants</h3> This study...
Thrombocytosis is associated with cancer progression and death for many types. It unclear if platelet count also survival. We conducted a cohort study of 112,231 adults in Ontario diagnosis between January 2007 December 2016. included patients who had complete blood (CBC) completed the 30 days prior to their diagnosis. Subjects were assigned one three categories according count: low (≤25th percentile), medium (>25 <75th high (≥75th percentile). Study subjects followed from date...
<h3>BACKGROUND:</h3> Understanding the extent to which current antibiotic prescribing behaviour is influenced by clinicians' historical patterns of practice will help target interventions optimize use in long-term care. Our objective was evaluate whether behaviours influence start, prolongation and class selection for treatment with antibiotics residents care facilities. <h3>METHODS:</h3> We conducted a retrospective cohort study all physicians who prescribed facilities Ontario between Jan....
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China, late 2019 and spread globally, resulting the COVID-19 pandemic. During two previous epidemics, Middle East syndrome, male sex was associated with worse clinical outcomes.1 Emerging incidence outcome data indicate that men, especially older may also be more affected.2-6 It is unclear whether these findings skewed because of unreported sex-based differences SARS-CoV-2 testing age distributions study...
Verbal autopsies (VA) are increasingly used in low- and middle-income countries where most causes of death (COD) occur at home without medical attention, deaths differ substantially from hospital deaths. Hence, there is no plausible "standard" against which VAs for may be validated. Previous studies have shown contradictory performance automated methods compared to physician-based classification CODs. We sought compare the classic naive Bayes classifier (NBC) versus existing classifiers,...
<h3>Importance</h3> Nursing home residents with advanced dementia have limited life expectancies yet are commonly subjected to burdensome interventions at the very end of life. Whether sex-specific differences in receipt these exist and what levels physical restraints antibiotics used this terminal setting unknown. <h3>Objective</h3> To evaluate population-based frequency, factors, sex antibiotic therapy among nursing dementia. <h3>Design, Setting, Participants</h3> This cohort study from...
Antiresorptive medications have been explored for treating knee osteoarthritis (OA); however, little data exist on the effects of today's more potent nitrogen-containing oral bisphosphonates radiographic disease-progression in patients with varying disease-severity, especially those who are not overweight. The primary objective this cohort study was to determine if use is protective against 2-year radiographic-progression OA Osteoarthritis Initiative (OAI) participants, stratified by...
Abstract Background/Objectives Gabapentinoids are commonly prescribed to relieve pain. The development of edema, an established adverse effect gabapentinoids, may lead a potentially harmful prescribing cascade whereby individuals subsequently diuretics and exposed diuretic‐induced events. frequency this is unknown. Our objective was measure the association between new dispensing gabapentinoid subsequent diuretic in older adults with low back Design Population‐based cohort study. Setting...
<h3>Importance</h3> Individuals with newly diagnosed cancer often have a high platelet count (thrombocytosis). Whether thrombocytosis is associated the presence of an undiagnosed remains unknown. <h3>Objective</h3> To assess whether new diagnosis subsequent risk among adults. <h3>Design, Setting, and Participants</h3> This population-based retrospective cohort study was conducted using linked laboratory data from Ontario, Canada, January 1, 2007, to December 31, 2017, follow-up until 2018....
Objective: The study evaluated the association between physician follow-up within 30 days after hospital discharge and psychiatric readmission subsequent 180 days. Methods: Among inpatients with schizophrenia who were discharged 2007 2012 in Ontario (N=19,132), those had a 30-day visit primary care (PCP) only, psychiatrist or both compared no-follow-up group. outcome was Secondary analyses stratified sample on basis of risk at discharge. Results: About 65% patients postdischarge. Psychiatric...
<h3>Importance</h3> Patients with ductal carcinoma in situ (DCIS) are treated radiotherapy to reduce their risk of local invasive recurrence after breast-conserving surgery. However, the association breast cancer survival patients DCIS has not yet been clearly established. <h3>Objective</h3> To determine extent which is associated reduced mortality a large cohort for DCIS, using propensity score–based matching approach. <h3>Design, Setting, and Participants</h3> This study women who had...
Background: The coronavirus disease 2019 (COVID-19) pandemic originated in China late and continues to spread globally (1).At the time of writing, there were nearly 2 million COVID-19 cases causing approximately 110 000 deaths across more than 200 affected countries territories (2).As some health care systems approach collapse, a pressing need exists for tools modeling capacity acute critical during pandemic.Objective: To develop an online tool estimate maximum number that could be managed...
Although sometimes appropriate, antipsychotic medications are associated with increased risk of significant adverse events. In 2014, a series newspaper articles describing high prescribing rates in nursing homes Ontario, Canada, garnered substantial interest. Subsequently, an online public reporting initiative home-level data was launched. We examined the impact these interventions on homes.Time analysis all home residents between 1 October 2013 and 31 March 2016. The primary outcome...
Importance Subtle but important differences have been described in the way that male and female physicians care for their patients, with some evidence suggesting women are more likely to adhere best practice recommendations. Objective To determine if differ prescribing practices as measured by initiation of lower-than-recommended dose cholinesterase inhibitor (ChEI) drug therapy dementia management. Design, setting, participants All community-dwelling Ontario residents aged 66 years older...