A5045224461- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- MicroRNA in disease regulation
- Microtubule and mitosis dynamics
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Sarcoma Diagnosis and Treatment
- Advanced X-ray and CT Imaging
- Genetic factors in colorectal cancer
- Renal cell carcinoma treatment
- Advanced MRI Techniques and Applications
- Statistical Methods and Inference
- Forecasting Techniques and Applications
- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Cardiac tumors and thrombi
- RNA Research and Splicing
- Neuroendocrine Tumor Research Advances
- Prostate Cancer Treatment and Research
- Cancer, Stress, Anesthesia, and Immune Response
- Colorectal Cancer Screening and Detection
Hunan Normal University
2025
Xiangya Hospital Central South University
2015-2024
Central South University
2015-2024
Monash University
2024
Southeast University
2021
Changsha University
2017
Sun Yat-sen Memorial Hospital
2016
Sun Yat-sen University
2016
Background Prediction of microvascular invasion (MVI) may help determine treatment strategies for hepatocellular carcinoma (HCC). Purpose To develop a radiomics approach predicting MVI status based on preoperative multiphase CT images and to identify MVI-associated differentially expressed genes. Materials Methods Patients with pathologically proven HCC from May 2012 September 2020 were retrospectively included four medical centers. Radiomics features extracted tumors peritumor regions...
Background: Conventional methods for predicting treatment response to neoadjuvant chemoradiotherapy (nCRT) in patients with locally advanced rectal cancer (LARC) are limited. Methods: This study retrospectively recruited 134 LARC who underwent standard nCRT followed by total mesorectal excision surgery our institution. Based on pre-operative axial T2-weighted images, machine learning radiomics was performed. A receiver operating characteristic (ROC) curve performed test the efficiencies of...
Objective: To evaluate the feasibility and accuracy of machine learning based texture analysis unenhanced CT images in differentiating subclinical pheochromocytoma (sPHEO) from lipid-poor adenoma (LPA) adrenal incidentaloma (AI).Methods: Seventy-nine patients with 80 LPA 29 30 sPHEO were included study.Texture parameters derived using imaging software (MaZda).Thirty features selected was performed for selected.The number positive used to predict results.Logistic multiple regression on...
The biological functions of exosomes and microRNAs (miRs) in nasopharyngeal carcinoma (NPC) remain largely unexplored. Here, miR-197-3p was screened identified, whose level reduced serum patients with NPC. MiR-197-3p might be a good diagnostic prognostic indicator. Our data showed that expression closely related to radioresistance, apoptosis, proliferation, migration, survival Inhibition vitro could promote the proliferation migration NPC cells, while promotion vivo significantly inhibit...
To assess the safety and efficacy of local ablation plus PD-1 inhibitor toripalimab in previously treated unresectable hepatocellular carcinoma (HCC).In multicenter, two-stage, randomized phase 1/2 trial, patients were randomly assigned to receive alone (240 mg, every 3 weeks), subtotal followed by starting on post-ablation day (Schedule D3), or 14 D14). The first endpoint stage 1 was determine which combination schedule could continue progression-free survival (PFS) as primary for 1/2.A...
Abstract Objectives Creeping fat is a kind of unique abnormal mesenteric tissue at the sites diseased bowel Crohn’s disease. By using dual-energy CT enterography, this study aimed to evaluate feasibility spectral parameters in quantitative analysis adipose or creeping fat. Methods In study, patients with known suspected disease who underwent enterography from March 1, 2019, 31, 2021, were enrolled. Among them, 40 surgery and pathology-proven selected as group, normal control group. The...
Summary Leaf morphogenesis is a crucial process in plants that governs essential physiological functions such as photosynthesis and transpiration. Despite significant advances understanding leaf development, the mechanism of intricate cellular patterning remains elusive. We characterize OsLC1 mutant, which displays curly phenotype alongside reductions plant height tiller number, are indicative multiple morphological abnormalities. Through map‐based cloning, we identified encoding...
Abstract Chronic opioid abusers are more susceptible to bacterial and viral infections, but the molecular mechanism underlying opioid-induced immunosuppression is unknown. MicroRNAs (miRNAs) emerging as key players in control of biological processes, may participate immune regulation. In this study, we investigated mechanisms miRNA-mediated immunosuppression, context miRNA dysregulation abusers. Blood samples heroin were collected analyzed using microarray analysis quantitative PCR...
Pancreatic cancer has one of the highest mortality rates among malignant tumors and is characterized by rapid invasion, early metastasis chemoresistance. X‑linked inhibitor apoptosis (XIAP) survivin are two most important members IAP family. Previous studies have shown that XIAP were overexpressed in pancreatic closely associated with cell proliferation chemoresistance to gemcitabine. In present study, stable inhibition Panc‑1 cells was performed using lentivirus‑carried short hairpin RNAs....
Increasing evidence has suggested that dysregulation of microRNAs (miRNAs) could contribute to tumor progression. Previous miRNA microarray analysis illustrated miR-335 is downregulated in various cancers; however, the role on hepatocellular carcinoma (HCC) not been well elucidated. In this study, we investigated biological functions and molecular mechanisms human HCC vitro, discussing whether it be a therapeutic biomarker future. Four cell lines samples from 62 patients with were analyzed...
Undetectable occult liver metastases block the long-term survival of pancreatic ductal adenocarcinoma (PDAC). This study aimed to develop a radiomics-based model predict and assess its prognostic capacity for survival.
Abstract Breast cancer is the most common malignancy among women worldwide. Kynureninase (KYNU) located in 2q22.2, which was associated with tryptophan utilization and metabolic diseases including cardiac, renal limb defects syndrome 2. However, role of KYNU breast (BC) development remains unclear. The expression examined by immunohistochemistry (IHC) 137 primary BC tissues, correlation clinical pathological characteristics biomarkers (ER, PR, HER2, E‐cad Ki‐67) analysed. cell proliferation,...
Tumor resistance to radiotherapy is one of the main obstacles clinical treatment nasopharyngeal carcinoma (NPC). Improving radiosensitivity tumor cells has an important significance in NPC. This study aimed identify that miR-138-1-3p as a novel therapeutic target radioresistant NPC and found its targets, CRIPTO JAK2/STAT3 pathway.Radioresistant C666-IR HK-1R were derived from cell lines C666-1 HK-1. The different microRNAs (miRNAs) their targeting genes analyzed between using microarray...
Abstract Objectives To evaluate signal enhancement ratio (SER) for tissue characterization and prognosis stratification in pancreatic adenocarcinoma (PDAC), with quantitative histopathological analysis (QHA) as the reference standard. Methods This retrospective study included 277 PDAC patients who underwent multi-phase contrast-enhanced (CE) MRI whole-slide imaging (WSI) from three centers (2015–2021). SER is defined (SI lt − SI pre )/(SI ea ), where , ea, represent intensity of tumor...
AIM:To study the diagnosis of hepatocellular carcinoma (HCC) presenting as bile duct tumor thrombus with no detectable intrahepatic mass. METHODS:Six patients pathologically proven HCC thrombi but mass demonstrated on preoperative imaging or palpated during operative exploration, were collected.Their clinical and data retrospectively analyzed.The major findings signs comprehensive correlated surgical pathologic findings. RESULTS:Jaundice was symptom patients.The elevated serum total...
Distinct vascular patterns, including microvascular invasion (MVI) and vessels encapsulating tumour clusters (VETC), are associated with poor outcomes of hepatocellular carcinoma (HCC). Imaging surrogates these patterns potentially help to predict post-resection recurrence. Herein, a prognostic model integrating imaging-based distinct was developed postoperative recurrence-free survival (RFS) in patients HCC.
Pancreatic cancer (PC) is one of the most aggressive types with an extremely poor prognosis. Invasive growth and early metastasis greatest challenges to overcome for treatment PC. Numerous previous studies have indicated that transcription factor Krüppel-like 8 (KLF8) nuclear cofactor four a half LIM-only protein 2 (FHL2) serve important roles in tumorigenesis tumor progression; however, their PC remain elusive. The present study revealed KLF8 FHL2 expression aberrantly co-overexpressed...
// Chengmin Li 1, * , Bin Zhang 2, Wuwu Lv 1 Chen Lai 3 Zhikang Ran Wang Xueying Long 4 Xueping Feng Institute of Medical Sciences, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China 2 Department Histology and Embryology, School Medicine, General Surgery, Radiology, These authors contributed equally to this work Correspondence to: Feng, email: fxp1029@aliyun.com Keywords: nasopharyngeal carcinoma, CNE2, radioresistance, triptolide, GRP78 Received: November 05,...