A5103030805- Adrenal and Paraganglionic Tumors
- Radiomics and Machine Learning in Medical Imaging
- Hormonal Regulation and Hypertension
- Pituitary Gland Disorders and Treatments
- Renal cell carcinoma treatment
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- AI in cancer detection
- Advanced X-ray and CT Imaging
- Gastric Cancer Management and Outcomes
- Bladder and Urothelial Cancer Treatments
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MRI in cancer diagnosis
- Apelin-related biomedical research
- Cancer Immunotherapy and Biomarkers
- Natural product bioactivities and synthesis
- Hormonal and reproductive studies
- Healthcare Systems and Reforms
- RNA Research and Splicing
- Biochemical Analysis and Sensing Techniques
- Urinary Bladder and Prostate Research
- Birth, Development, and Health
- Colorectal Cancer Screening and Detection
- Curcumin's Biomedical Applications
Chongqing Medical and Pharmaceutical College
2025
Central South University
2014-2024
Xiangya Hospital Central South University
2014-2024
Second Affiliated Hospital of Nanjing Medical University
2022-2023
Guilin Medical University
2021-2023
National Clinical Research Center for Digestive Diseases
2022
Nanjing Medical University
2022
Peking Union Medical College Hospital
2020
Chinese Academy of Medical Sciences & Peking Union Medical College
2020
Army Medical University
2016-2017
Background Clear cell renal carcinoma (ccRCC) is the most common cancer and it has worst prognosis among all cancers. However, traditional radiological characteristics on computed tomography (CT) scans of ccRCC have been insufficient to predict pathological grade before surgery. Methods Patients with were retrospectively enrolled into this study separated two groups according World Health Organization (WHO)/International Society Urological Pathology (ISUP) grading system, i.e., low-grade...
Abstract Maternal inflammation contributes to the increased incidence of adult cardiovascular disease. The current study investigated susceptibility cardiac damage responding isoproterenol (ISO) in offspring that underwent maternal (modeled by pregnant Sprague-Dawley rats with lipopolysaccharides (LPS) challenge). We found 2 weeks ISO treatment LPS-treated mothers led augmented heart damage, characterized left-ventricular systolic dysfunction, hypertrophy and myocardial fibrosis....
To assess the accuracy of computed tomography (CT)-based machine learning models for differentiating subclinical pheochromocytoma (sPHEO) from lipid-poor adenoma (LPA) in patients with adrenal incidentalomas.The study included 188 tumors 183 LPA and 92 86 sPHEO. Pre-enhanced CT imaging features were evaluated. Machine prediction scoring systems sPHEO built using logistic regression (LR), support vector (SVM) random forest (RF) approaches.The LR model performed better than other models. The...
Computed tomography is the most commonly used imaging modality for preoperative assessment of lymph node status, but reported accuracy unsatisfactory. To evaluate and verify predictive performance computed deep learning on presurgical evaluation metastasis in patients with gastric cancer. 347 were retrospectively selected (training cohort: 242, test 105). The enhanced arterial phase images cancer lesion segmentation, radiomics feature extraction. Three methods selection. Support vector...
Chronic prostatitis/Chronic pelvic pain syndrome (CP/CPPS) is the most common type of prostatitis. Due to lack a suitable animal model partly, pathogenesis for this condition obscure. In current study we developed and validated an nonbacterial prostatitis prostate inflammation-induced chronic in rats with use intraprostatic injection λ-carrageenan.
Fast-track surgery (FTS), which combines various techniques with evidence-based adjustments, is aimed to reduce postoperative morbidity, attenuate surgical stress response, thereby accelerating recovery and shorting length of stay. To further investigate the effectiveness fast-track surgery, we compared short-term outcomes laparoscopic radical cystectomy ileal conduit diversion for Chinese bladder cancer patients FTS or CS in our hospital. Patients were included divided into two consecutive...
The urinary, psychosocial, organ-specific, infection, neurological/systemic and tenderness (UPOINT) phenotype system has been validated to be an effective in classifying patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) western populations. To validate the utility of UPOINT evaluate effect multimodal therapy based on Chinese CP/CPPS, we performed this study. CP/CPPS were prospectively offered using re-examined after 6 months. A minimum 6-point drop National Institutes...
Prenatal exposure to an inflammatory stimulus has been shown cause renal damage in offspring. Our present study explored the role of intra-renal NF-κB activation development progressive fibrosis offspring that underwent prenatal stimulus. Time-dated pregnant rats were treated with saline (control group) or 0.79 mg/kg lipopolysaccharide (LPS) through intra-peritoneal injection on gestational day 8, 10 and 12. At age 7 weeks, from control LPS group either tap water (Con+Ve LPS+Ve pyrollidine...
Abstract Context Intraoperative hemodynamic instability (HDI) can lead to cardiovascular and cerebrovascular complications during surgery for pheochromocytoma/paraganglioma (PPGL). Objectives We aimed assess the risk of intraoperative HDI in patients with PPGL improve surgical outcome. Methods A total 199 consecutive confirmed by pathology were retrospectively included this study. This cohort was separated into 2 groups according systolic blood pressure, group (n = 101) stability (HDS) 98)....
Abstract Background Maintaining intraoperative haemodynamic stability can reduce cardiovascular complications during surgery for pheochromocytoma and paraganglioma (PPGL). Risk factors such as tumour size catecholamine levels are reported to predict responses PPGL. We hypothesized that additional including body composition genetic information could further improve prediction. Methods Consecutive patients with PPGL confirmed by surgical pathology between June 2010 2019 were retrospectively...
Abstract Context Pheochromocytomas and paragangliomas (PPGLs) are being increasingly discovered by imaging performed for unrelated conditions. The genetic landscape of incidental PPGLs remains to be elucidated. Objective We aimed describe the characteristics incidentally in a large PPGL cohort. Methods This retrospective cross-sectional study included 697 patients with pathology confirmed PPGLs, including 283 incidentalomas 414 nonincidentalomas, at 2 tertiary care centers China 2009-2019....
This study aimed to compare the World Health Organization/International Society of Urological Pathology (WHO/ISUP) grading system and Fuhrman verify WHO/ISUP grade as a prognostic parameter clear cell renal carcinoma (ccRCC) in Chinese population.The consisted 753 ccRCC patients treated with curative surgery between 2010 2018 at Xiangya Hospital Central South University (Changsha, China). All pathologic data were retrospectively reviewed by two pathologists. Cancer-specific survival (CSS)...
Abstract Mammalian cardiomyocytes undergo a critical hyperplastic-to-hypertrophic growth transition at early postnatal age, which is important in establishing normal physiological function of hearts. In the current study, we intended to explore role long non-coding (lnc) RNAs this transitional stage. We analyzed lncRNA expression profiles mouse hearts day (P) 1, P7 and P28 via microarray. identified 1,146 differentially expressed lncRNAs with more than 2.0-fold change when compared P1 P7,...