A5056377023- Immune Cell Function and Interaction
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Cytomegalovirus and herpesvirus research
- RNA modifications and cancer
- Mitochondrial Function and Pathology
- Cancer-related molecular mechanisms research
- Adipose Tissue and Metabolism
- Immune Response and Inflammation
- HVDC Systems and Fault Protection
- IL-33, ST2, and ILC Pathways
- Cytokine Signaling Pathways and Interactions
- Pharmacological Effects of Natural Compounds
- Metabolism and Genetic Disorders
- Environmental Impact and Sustainability
- Autophagy in Disease and Therapy
- Vehicle emissions and performance
- Immune cells in cancer
- Energy, Environment, and Transportation Policies
Army Medical University
2021-2025
China Academy of Transportation Sciences
2022
Although great progresses have been made in the diagnosis and treatment of hepatocellular carcinoma (HCC), its prognostic marker remains controversial. In this current study, weighted correlation network analysis Cox regression showed significant value five autophagy-related long non-coding RNAs (AR-lncRNAs) (including TMCC1-AS1, PLBD1-AS1, MKLN1-AS, LINC01063, CYTOR) for HCC patients from data The Cancer Genome Atlas. By using them, we constructed a five-AR-lncRNA signature, which...
NK cells can be rapidly activated in response to cytokines during host defense against malignant or viral infection. However, it remains unclear what mechanisms precisely and regulate the expression of a large number genes involved activating cells. In this study, we discovered that NK-cell N6-methyladenosine (m6A) methylation levels were upregulated upon short-term activation repressed tumor microenvironment (TME). Deficiency methyltransferase-like 3 (METTL3) METTL14 moderately influenced...
Chinese government has proposed ambitious targets to combat climate change. As carbon emissions of China’s transportation have been rapidly increasing in past decades, massive efforts for reduction need be taken by sector. Research on practical action paths sector’s low-carbon development are critical achieving the Paris Agreement goals and “Dual-Carbon” Target. Based transportation’s historical new possible trends future, this paper uses a forecast model predict emission. Then we adopt...
<div>Abstract<p>NK cells can be rapidly activated in response to cytokines during host defense against malignant or viral infection. However, it remains unclear what mechanisms precisely and regulate the expression of a large number genes involved activating NK cells. In this study, we discovered that NK-cell <i>N</i><sup>6</sup>-methyladenosine (m<sup>6</sup>A) methylation levels were upregulated upon short-term activation repressed tumor...
Abstract Background Docosahexaenoic acid (DHA) supplementation is beneficial for several chronic diseases; however, its effect on immune regulation still debated. Given the prevalence of cytomegalovirus (CMV) infection and because natural killer (NK) cells are a component innate immunity critical controlling CMV infection, current study explored DHA-enriched diet susceptibility to murine (M) NK cell effector response MCMV infection. Results Male C57BL/6 mice fed control or 3 weeks were...
Natural killer (NK) cells play important roles in controlling virus-infected and malignant cells. The identification of new molecules that can activate NK may effectively improve the antiviral antitumour activities these In this study, by using a commercially available metabolism-related compound library, we initially screened capacity compounds to determining ratio interferon-gamma (IFN-γ)+ flow cytometry after incubation peripheral blood mononuclear (PBMCs) with IL-12 or IL-15 for 18 h....
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<div>Abstract<p>NK cells can be rapidly activated in response to cytokines during host defense against malignant or viral infection. However, it remains unclear what mechanisms precisely and regulate the expression of a large number genes involved activating NK cells. In this study, we discovered that NK-cell <i>N</i><sup>6</sup>-methyladenosine (m<sup>6</sup>A) methylation levels were upregulated upon short-term activation repressed tumor...
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