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Yan Ji

ORCID: 0009-0007-4506-8788
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A5001581319
Research Areas
  • Immune Cell Function and Interaction
  • Cancer-related gene regulation
  • Epigenetics and DNA Methylation
  • Diamond and Carbon-based Materials Research
  • RNA modifications and cancer
  • High-Temperature Coating Behaviors
  • Tribology and Wear Analysis
  • HVDC Systems and Fault Protection

Army Medical University
 2024

 mTOR Signaling Promotes Rapid m6A mRNA Methylation to Regulate NK-Cell Activation and Effector Functions
OPENALEX - Publications 
Meng Meng Zhaoyang Zhong Liang Song Zhaohui Zhang Xiaofeng Yin and 18 more Xiqiang Xie Lei Tian Wei Wu Yao Yang Yafei Deng Hongyan Peng Shuting Wu Guanghe Ran Yuqing Lin Qiangqiang Lai Qinghua Bi Fulin Yan Yan Ji Yang Wang Xiaohui Li Ping Yi Jianhua Yu Youcai Deng

NK cells can be rapidly activated in response to cytokines during host defense against malignant or viral infection. However, it remains unclear what mechanisms precisely and regulate the expression of a large number genes involved activating cells. In this study, we discovered that NK-cell N6-methyladenosine (m6A) methylation levels were upregulated upon short-term activation repressed tumor microenvironment (TME). Deficiency methyltransferase-like 3 (METTL3) METTL14 moderately influenced...

10.1158/2326-6066.cir-23-0339 article EN Cancer Immunology Research 2024-04-19
 Data from mTOR Signaling Promotes Rapid m<sup>6</sup>A mRNA Methylation to Regulate NK-Cell Activation and Effector Functions
OPENALEX - Publications 
Meng Meng Zhaoyang Zhong Liang Song Zhaohui Zhang Xiaofeng Yin and 18 more Xiqiang Xie Lei Tian Wei Wu Yao Yang Yafei Deng Hongyan Peng Shuting Wu Guanghe Ran Yuqing Lin Qiangqiang Lai Qinghua Bi Fulin Yan Yan Ji Yang Wang Xiaohui Li Ping Yi Jianhua Yu Youcai Deng

&lt;div&gt;Abstract&lt;p&gt;NK cells can be rapidly activated in response to cytokines during host defense against malignant or viral infection. However, it remains unclear what mechanisms precisely and regulate the expression of a large number genes involved activating NK cells. In this study, we discovered that NK-cell &lt;i&gt;N&lt;/i&gt;&lt;sup&gt;6&lt;/sup&gt;-methyladenosine (m&lt;sup&gt;6&lt;/sup&gt;A) methylation levels were upregulated upon short-term activation repressed tumor...

10.1158/2326-6066.c.7380107 preprint EN 2024-08-01
 Supplementary Figure S3 from mTOR Signaling Promotes Rapid m<sup>6</sup>A mRNA Methylation to Regulate NK-Cell Activation and Effector Functions
OPENALEX - Publications 
Meng Meng Zhaoyang Zhong Liang Song Zhaohui Zhang Xiaofeng Yin and 18 more Xiqiang Xie Lei Tian Wei Wu Yao Yang Yafei Deng Hongyan Peng Shuting Wu Guanghe Ran Yuqing Lin Qiangqiang Lai Qinghua Bi Fulin Yan Yan Ji Yang Wang Xiaohui Li Ping Yi Jianhua Yu Youcai Deng

&lt;p&gt;Supplementary Figure S3&lt;/p&gt;

10.1158/2326-6066.26423090 preprint EN cc-by 2024-08-01
 Supplementary Figure S1 from mTOR Signaling Promotes Rapid m<sup>6</sup>A mRNA Methylation to Regulate NK-Cell Activation and Effector Functions
OPENALEX - Publications 
Meng Meng Zhaoyang Zhong Liang Song Zhaohui Zhang Xiaofeng Yin and 18 more Xiqiang Xie Lei Tian Wei Wu Yao Yang Yafei Deng Hongyan Peng Shuting Wu Guanghe Ran Yuqing Lin Qiangqiang Lai Qinghua Bi Fulin Yan Yan Ji Yang Wang Xiaohui Li Ping Yi Jianhua Yu Youcai Deng

&lt;p&gt;Supplementary Figure S1&lt;/p&gt;

10.1158/2326-6066.26423096 preprint EN cc-by 2024-08-01
 Supplementary Figure S1 from mTOR Signaling Promotes Rapid m<sup>6</sup>A mRNA Methylation to Regulate NK-Cell Activation and Effector Functions
OPENALEX - Publications 
Meng Meng Zhaoyang Zhong Liang Song Zhaohui Zhang Xiaofeng Yin and 18 more Xiqiang Xie Lei Tian Wei Wu Yao Yang Yafei Deng Hongyan Peng Shuting Wu Guanghe Ran Yuqing Lin Qiangqiang Lai Qinghua Bi Fulin Yan Yan Ji Yang Wang Xiaohui Li Ping Yi Jianhua Yu Youcai Deng

&lt;p&gt;Supplementary Figure S1&lt;/p&gt;

10.1158/2326-6066.26423096.v1 preprint EN cc-by 2024-08-01
 Supplementary Figure S7 from mTOR Signaling Promotes Rapid m<sup>6</sup>A mRNA Methylation to Regulate NK-Cell Activation and Effector Functions
OPENALEX - Publications 
Meng Meng Zhaoyang Zhong Liang Song Zhaohui Zhang Xiaofeng Yin and 18 more Xiqiang Xie Lei Tian Wei Wu Yao Yang Yafei Deng Hongyan Peng Shuting Wu Guanghe Ran Yuqing Lin Qiangqiang Lai Qinghua Bi Fulin Yan Yan Ji Yang Wang Xiaohui Li Ping Yi Jianhua Yu Youcai Deng

&lt;p&gt;Supplementary Figure S7&lt;/p&gt;

10.1158/2326-6066.26423078 preprint EN cc-by 2024-08-01
 Supplementary Figure S3 from mTOR Signaling Promotes Rapid m<sup>6</sup>A mRNA Methylation to Regulate NK-Cell Activation and Effector Functions
OPENALEX - Publications 
Meng Meng Zhaoyang Zhong Liang Song Zhaohui Zhang Xiaofeng Yin and 18 more Xiqiang Xie Lei Tian Wei Wu Yao Yang Yafei Deng Hongyan Peng Shuting Wu Guanghe Ran Yuqing Lin Qiangqiang Lai Qinghua Bi Fulin Yan Yan Ji Yang Wang Xiaohui Li Ping Yi Jianhua Yu Youcai Deng

&lt;p&gt;Supplementary Figure S3&lt;/p&gt;

10.1158/2326-6066.26423090.v1 preprint EN cc-by 2024-08-01
 Supplementary Figure S5 from mTOR Signaling Promotes Rapid m<sup>6</sup>A mRNA Methylation to Regulate NK-Cell Activation and Effector Functions
OPENALEX - Publications 
Meng Meng Zhaoyang Zhong Liang Song Zhaohui Zhang Xiaofeng Yin and 18 more Xiqiang Xie Lei Tian Wei Wu Yao Yang Yafei Deng Hongyan Peng Shuting Wu Guanghe Ran Yuqing Lin Qiangqiang Lai Qinghua Bi Fulin Yan Yan Ji Yang Wang Xiaohui Li Ping Yi Jianhua Yu Youcai Deng

&lt;p&gt;Supplementary Figure S5&lt;/p&gt;

10.1158/2326-6066.26423084 preprint EN cc-by 2024-08-01
 Supplementary Figure S6 from mTOR Signaling Promotes Rapid m<sup>6</sup>A mRNA Methylation to Regulate NK-Cell Activation and Effector Functions
OPENALEX - Publications 
Meng Meng Zhaoyang Zhong Liang Song Zhaohui Zhang Xiaofeng Yin and 18 more Xiqiang Xie Lei Tian Wei Wu Yao Yang Yafei Deng Hongyan Peng Shuting Wu Guanghe Ran Yuqing Lin Qiangqiang Lai Qinghua Bi Fulin Yan Yan Ji Yang Wang Xiaohui Li Ping Yi Jianhua Yu Youcai Deng

&lt;p&gt;Supplementary Figure S6&lt;/p&gt;

10.1158/2326-6066.26423081.v1 preprint EN cc-by 2024-08-01
 Data from mTOR Signaling Promotes Rapid m<sup>6</sup>A mRNA Methylation to Regulate NK-Cell Activation and Effector Functions
OPENALEX - Publications 
Meng Meng Zhaoyang Zhong Liang Song Zhaohui Zhang Xiaofeng Yin and 18 more Xiqiang Xie Lei Tian Wei Wu Yao Yang Yafei Deng Hongyan Peng Shuting Wu Guanghe Ran Yuqing Lin Qiangqiang Lai Qinghua Bi Fulin Yan Yan Ji Yang Wang Xiaohui Li Ping Yi Jianhua Yu Youcai Deng

&lt;div&gt;Abstract&lt;p&gt;NK cells can be rapidly activated in response to cytokines during host defense against malignant or viral infection. However, it remains unclear what mechanisms precisely and regulate the expression of a large number genes involved activating NK cells. In this study, we discovered that NK-cell &lt;i&gt;N&lt;/i&gt;&lt;sup&gt;6&lt;/sup&gt;-methyladenosine (m&lt;sup&gt;6&lt;/sup&gt;A) methylation levels were upregulated upon short-term activation repressed tumor...

10.1158/2326-6066.c.7380107.v1 preprint EN 2024-08-01
 Supplementary Figure S4 from mTOR Signaling Promotes Rapid m<sup>6</sup>A mRNA Methylation to Regulate NK-Cell Activation and Effector Functions
OPENALEX - Publications 
Meng Meng Zhaoyang Zhong Liang Song Zhaohui Zhang Xiaofeng Yin and 18 more Xiqiang Xie Lei Tian Wei Wu Yao Yang Yafei Deng Hongyan Peng Shuting Wu Guanghe Ran Yuqing Lin Qiangqiang Lai Qinghua Bi Fulin Yan Yan Ji Yang Wang Xiaohui Li Ping Yi Jianhua Yu Youcai Deng

&lt;p&gt;Supplementary Figure S4&lt;/p&gt;

10.1158/2326-6066.26423087 preprint EN cc-by 2024-08-01
 Supplementary Figure S2 from mTOR Signaling Promotes Rapid m<sup>6</sup>A mRNA Methylation to Regulate NK-Cell Activation and Effector Functions
OPENALEX - Publications 
Meng Meng Zhaoyang Zhong Liang Song Zhaohui Zhang Xiaofeng Yin and 18 more Xiqiang Xie Lei Tian Wei Wu Yao Yang Yafei Deng Hongyan Peng Shuting Wu Guanghe Ran Yuqing Lin Qiangqiang Lai Qinghua Bi Fulin Yan Yan Ji Yang Wang Xiaohui Li Ping Yi Jianhua Yu Youcai Deng

&lt;p&gt;Supplementary Figure S2&lt;/p&gt;

10.1158/2326-6066.26423093 preprint EN 2024-08-01
 Supplementary Figure S2 from mTOR Signaling Promotes Rapid m<sup>6</sup>A mRNA Methylation to Regulate NK-Cell Activation and Effector Functions
OPENALEX - Publications 
Meng Meng Zhaoyang Zhong Liang Song Zhaohui Zhang Xiaofeng Yin and 18 more Xiqiang Xie Lei Tian Wei Wu Yao Yang Yafei Deng Hongyan Peng Shuting Wu Guanghe Ran Yuqing Lin Qiangqiang Lai Qinghua Bi Fulin Yan Yan Ji Yang Wang Xiaohui Li Ping Yi Jianhua Yu Youcai Deng

&lt;p&gt;Supplementary Figure S2&lt;/p&gt;

10.1158/2326-6066.26423093.v1 preprint EN cc-by 2024-08-01
 Supplementary Figure S7 from mTOR Signaling Promotes Rapid m<sup>6</sup>A mRNA Methylation to Regulate NK-Cell Activation and Effector Functions
OPENALEX - Publications 
Meng Meng Zhaoyang Zhong Liang Song Zhaohui Zhang Xiaofeng Yin and 18 more Xiqiang Xie Lei Tian Wei Wu Yao Yang Yafei Deng Hongyan Peng Shuting Wu Guanghe Ran Yuqing Lin Qiangqiang Lai Qinghua Bi Fulin Yan Yan Ji Yang Wang Xiaohui Li Ping Yi Jianhua Yu Youcai Deng

&lt;p&gt;Supplementary Figure S7&lt;/p&gt;

10.1158/2326-6066.26423078.v1 preprint EN cc-by 2024-08-01
 Supplementary Figure S6 from mTOR Signaling Promotes Rapid m<sup>6</sup>A mRNA Methylation to Regulate NK-Cell Activation and Effector Functions
OPENALEX - Publications 
Meng Meng Zhaoyang Zhong Liang Song Zhaohui Zhang Xiaofeng Yin and 18 more Xiqiang Xie Lei Tian Wei Wu Yao Yang Yafei Deng Hongyan Peng Shuting Wu Guanghe Ran Yuqing Lin Qiangqiang Lai Qinghua Bi Fulin Yan Yan Ji Yang Wang Xiaohui Li Ping Yi Jianhua Yu Youcai Deng

&lt;p&gt;Supplementary Figure S6&lt;/p&gt;

10.1158/2326-6066.26423081 preprint EN cc-by 2024-08-01
 Supplementary Figure S5 from mTOR Signaling Promotes Rapid m<sup>6</sup>A mRNA Methylation to Regulate NK-Cell Activation and Effector Functions
OPENALEX - Publications 
Meng Meng Zhaoyang Zhong Liang Song Zhaohui Zhang Xiaofeng Yin and 18 more Xiqiang Xie Lei Tian Wei Wu Yao Yang Yafei Deng Hongyan Peng Shuting Wu Guanghe Ran Yuqing Lin Qiangqiang Lai Qinghua Bi Fulin Yan Yan Ji Yang Wang Xiaohui Li Ping Yi Jianhua Yu Youcai Deng

&lt;p&gt;Supplementary Figure S5&lt;/p&gt;

10.1158/2326-6066.26423084.v1 preprint EN cc-by 2024-08-01
 Supplementary Figure S4 from mTOR Signaling Promotes Rapid m<sup>6</sup>A mRNA Methylation to Regulate NK-Cell Activation and Effector Functions
OPENALEX - Publications 
Meng Meng Zhaoyang Zhong Liang Song Zhaohui Zhang Xiaofeng Yin and 18 more Xiqiang Xie Lei Tian Wei Wu Yao Yang Yafei Deng Hongyan Peng Shuting Wu Guanghe Ran Yuqing Lin Qiangqiang Lai Qinghua Bi Fulin Yan Yan Ji Yang Wang Xiaohui Li Ping Yi Jianhua Yu Youcai Deng

&lt;p&gt;Supplementary Figure S4&lt;/p&gt;

10.1158/2326-6066.26423087.v1 preprint EN cc-by 2024-08-01
 Cell Biology and Signaling
OPENALEX - Publications 
P. M. Long U. V. Wesley D. M. Jaworski M. Rana T.-R. Kiehl and 95 more K. So P. Gould N. Ajewung D. Kamnasaran M. R. Emmett X. Wang A. G. Marshall Yan Ji I. Fokt S. Skora C. A. Conrad W. Priebe H. Zhu X. Cao S. Keir F. Ali-Osman Hui‐Wen Lo Clóvis Orlando da Fonseca Vishalakshi Arun J. C. Wiley Hardeesh Kaur A. Guha K. Fenton M. G. Abdelwahab P. Stafford J. M. Rho M. C. Preul A. C. Scheck N. M. Brossier S. L. Carroll A. Gajadhar A. Guha J. Mukherjee A. Wolf C. Hawkins A. Guha P. Costa Ana L. Cardoso L. P. de Almeida Maria C. Pedroso de Lima P. Canoll J. Bruce I. Lavon A. Granit O. Einstein T. Ben-Hur T. Siegal Jia Chern Pang W. S. Poon L. Zhou H.-K. Ng R. A. Rovin J. E. Lawrence J. J. Segula R. J. Winn Sagar Patil Stanisław R. Burzyński E. Mrowczynski K. Grela Sy‐Chyi Cheng K. Liu Huali Feng Renas Bacho A. Kazlauskas E. M. Smith K. Symes Bingjie Hu C. Y. Lee A. Fotovati S. E. Dunn M. A. Proescholdt E.-M. Storr A. Lohmeier A. Brawanski Bingjie Hu Huali Feng M. J. Jarzynka K. Liu K. S. Ravichandran K. Vuori C. Tang R. Nshikawa T. G. Johns F. B. Furnari W. K. Cavenee Sy‐Chyi Cheng J. Zhong G. M. O'Neill Loic P. Deleyrolle M. Rahman E. M. Dunbar M. A. Caldeira B. A. Reynolds X. Liu S. Yacyshyn

10.1093/neuonc/noq116.s2 article EN Neuro-Oncology 2010-10-21
 Influence of Interface Temperature and Strain Gradients on Impact Energy Model of Soft Particle on Hard Substrate in Kinetic Spraying
OPENALEX - Publications 
Yan Ji S. Yoon G. Bae S. Kumar C. Lee and 1 more H. Choi

Abstract In this study, individual particle impact behaviors of soft on hard substrate were observed. The ratio bonds was compared to the difference between adhesion and rebound energies. To improve existing model, equation for effective yield strength modified finite element analysis applied estimate temperature strain gradients. energy derived from elements experimental bonds.

10.31399/asm.cp.itsc2008p1262 article EN Thermal spray 2008-06-02
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