A5100394411- Advanced Neuroimaging Techniques and Applications
- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Functional Brain Connectivity Studies
- Nephrotoxicity and Medicinal Plants
- Monoclonal and Polyclonal Antibodies Research
- Multiple Sclerosis Research Studies
- Cardiac Imaging and Diagnostics
- Marine Sponges and Natural Products
- Renal Diseases and Glomerulopathies
- Stroke Rehabilitation and Recovery
- Glycosylation and Glycoproteins Research
- Drug-Induced Hepatotoxicity and Protection
- Microbial Natural Products and Biosynthesis
- Advancements in Battery Materials
- Advanced Battery Materials and Technologies
- Cerebral Palsy and Movement Disorders
- Advanced Battery Technologies Research
- Proteins in Food Systems
- Coronary Interventions and Diagnostics
- Renal cell carcinoma treatment
- Boron Compounds in Chemistry
- Medical Imaging Techniques and Applications
- Cancer Research and Treatments
Nanjing University
2015-2025
National Clinical Research Center for Digestive Diseases
2025
Air Force Medical University
2025
Xijing Hospital
2025
Nanjing University of Chinese Medicine
2016-2024
Yangzhou University
2021-2024
Shanghai Institute of Technology
2024
State Key Laboratory of Pharmaceutical Biotechnology
2024
Second Affiliated Hospital of Nanchang University
2024
Nanchang University
2024
Little is currently known about the alterations in topological organization of white matter (WM) structural networks patients with multiple sclerosis (MS). In present study, we used diffusion tensor imaging and deterministic tractography to map WM 39 MS age- gender-matched healthy controls. Graph theoretical methods were applied investigate network efficiency these patients. The controls exhibited efficient small-world properties their networks. However, global local efficiencies...
Resistance remains an obstacle to anti-programmed cell death protein 1 (PD-1) therapy in human cancer. One critical resistance mechanism is the lack of T chemotaxis tumor microenvironment (TME). CXCL10-CXCR3 signaling required for infiltration and immunotherapy. Oncolytic viruses (OVs), including oncolytic adenoviruses (AdVs), induce effective immunity infiltration. Thus, arming OV with CXCL10 would be attractive strategy overcome anti-PD1 therapy. Here, we successfully constructed a novel...
Abstract The brain connectome of multiple sclerosis (MS) has been investigated by several previous studies; however, it is still unknown how the network changes in clinically isolated syndrome (CIS), earliest stage MS, and alterations on a functional level relate to structural MS disease. Here, we topological both connectomes 41 CIS 32 patients, compared 35 healthy controls, combining diffusion tensor imaging resting-state MRI with graph analysis approaches. We found that showed deviation...
Background: It remains uncertain whether neuromyelitis optica (NMO) exhibits diffuse cerebral abnormalities or the pathology is truly restricted to optic nerves and spinal cord in majority of cases. We examined NMO patients with diffusion tensor imaging (DTI) utilized a tract-based spatial statistics (TBSS) method analyze data. Methods: Twenty-seven (25 females, age mean ± SD: 35.1 12 years) 27 age- sex-matched normal controls were included this study. Voxel-wise analyses performed TBSS...
Polyhedral borane derivatives have been utilized in the treatment of boron neuron capture therapy (BNCT) for brain glioma, and much attention has paid to search excellent biocompatible boron-rich composites effective cancer BNCT therapy. In this study, we exploited self-assembly gold nanoclusters with carborane amino (GNCs-CB) precise bioimaging cells targeted delivery compound tumors. Our observations demonstrate that GNCs-CB can readily realize accurate tumor imaging long-term accumulation...
Hepatocellular carcinoma (HCC) is a well-known inflammation-related cancer, that accounts for fifth most prevalent neoplasm and the third major driver of cancer associated fatality globally. Accumulating evidence has elucidated C-X-C motif chemokine ligands (CXCLs) are aberrantly upregulated in HCC involved inflammation-induced hepatocarcinogenesis metastasis. Herein, we identified novel function DEAD-box RNA helicase 17 (DDX17) as an oncogenic factor via transactivating CXCL8 HCC. Unlike...
Arterial spin labeling (ASL) magnetic resonance (MR) perfusion imaging has been proposed as an effective method to measure brain tumor perfusion. The aim of the present study was evaluate utility this technique in differentiation recurrent gliomas from radiation necrosis. Twenty-one patients with surgically treated primary gliomas, including 16 cases glioma and 5 necrosis were examined using 3.0T MR (MRI). ASL dynamic susceptibility contrast-weighted (DSC) MRI scans performed. Maps...
Objective To investigate the topological alterations of whole-brain white-matter (WM) structural networks in patients with neuromyelitis optica (NMO). Methods The present study involved 26 NMO and age- sex-matched healthy controls. WM connectivity each participant was imaged diffusion-weighted MRI represented terms a matrix using deterministic tractography method. Graph theory-based analyses were then performed for characterization brain network properties. A multiple linear regression...
Acyl migration of fatty acid at sn-2 is often observed alongside enzymatic interesterification (EIE), causing the loss lipase selectivity toward acyl group sn-1,3. In this study, an oil blend consisting palm stearin (PST) and olein (POL) was interesterified via a chemical (CIE) method using packed bed reactor. Characterization in terms triacylglycerol (TAG) compositions, distributions, solid fat content profiles performed. comparison to that CIE fats, EIE fats showed different modification...
Objective : To investigate the efficacy and safety of a novel lower-limb exoskeletal robot, BEAR-H1 (Shenzhen Milebot Robot Technology), in locomotor function subacute stroke patients. Methods The present study was approved by ethical committee First Affiliated Hospital Nanjing Medical University (No. 2019-MD-43), registration recorded on Chinese Clinical Trial Registry with unique identifier: ChiCTR2100044475. A total 130 patients within 6 months were randomly divided into two groups: robot...
The rs72613567:TA polymorphism in 17-beta hydroxysteroid dehydrogenase 13 (HSD17B13) has been found to reduce the progression from steatosis nonalcoholic steatohepatitis. In this study, we sought define pathogenic role of HSD17B13 triggering liver inflammation. Here find that forms liquid-liquid phase separation (LLPS) around lipid droplets livers steatohepatitis patients. dimerization supports LLPS formation and promotes its enzymatic function. increases biosynthesis platelet activating...
Abstract Objectives To evaluate signal enhancement ratio (SER) for tissue characterization and prognosis stratification in pancreatic adenocarcinoma (PDAC), with quantitative histopathological analysis (QHA) as the reference standard. Methods This retrospective study included 277 PDAC patients who underwent multi-phase contrast-enhanced (CE) MRI whole-slide imaging (WSI) from three centers (2015–2021). SER is defined (SI lt − SI pre )/(SI ea ), where , ea, represent intensity of tumor...
Aim: Diosbulbin B (DB) is a major diterpenoid compound found in Dioscorea bulbifera L, traditional medicinal herb China. Clinical reports have confirmed that L. can induce significant hepatotoxicity. In this study, we showed DB mitochondria-dependent apoptosis and investigated the role of autophagy DB-induced hepatotoxicity L-02 hepatocytes. Methods: hepatocytes were treated with different concentrations for 48 h, after which indicators measured. 3-Methyladenine (3-MA) rapamycin (Rapa) used...
The cathode materials of Li-ion batteries for electric vehicles require not only a large gravimetric capacity but also high volumetric capacity. A new Li-rich layered oxide with superior capacity, Li[Li0.20Ni0.16Co0.10Mn0.54]O2 (denoted as LNCM), is synthesized from precursor, coprecipitated spherical metal hydroxide. preparation technology precursor such stirring speed, concentration solution, and reaction time are regulated elaborately. final product LNCM shows well-ordered,...
Abstract In this work, we propose an effective way to prepare nanosized Li 4 Ti 5 O 12 (LTO) microspheres and 0.5 2 MnO 3 ⋅0.5 LiNi 0.4 Co 0.2 Mn (NCM) by similar spray‐drying methods. Both obtained materials are accumulated primary nanoparticles show a spherical morphology with particle distribution of 10–20 μm. The LTO deliver tap density 1.04 g cm −3 , while the NCM is 2.07 which means enhanced volumetric energy density. as‐prepared have reversible capacity 170 mA h −1 at 0.1 C retention...
Mesophotic coral ecosystems (MCEs) have complex but understudied biodiversity, especially for natural products discovery. Untargeted metabolomics research on 80 extracts prepared from marine sponge-associated fungi, half shallow reefs (<30 m) and MCEs (30–150 m), facilitated prioritization further study a Cymostachys fungus 103 m deep Aaptos sponge. LC-MS target-directed isolation yielded series of new compounds, cymopolyphenols A−F ( 1 – 6 ), two known phenylspirodrimanes, F1839-I 7...