A5054826252- Cancer-related molecular mechanisms research
- Radiomics and Machine Learning in Medical Imaging
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Sarcoma Diagnosis and Treatment
- PI3K/AKT/mTOR signaling in cancer
- RNA modifications and cancer
- Colorectal Cancer Surgical Treatments
- Pancreatic and Hepatic Oncology Research
- Potassium and Related Disorders
- Cancer-related gene regulation
- Colorectal Cancer Screening and Detection
- Kruppel-like factors research
- Calcium signaling and nucleotide metabolism
- Extracellular vesicles in disease
- RNA Research and Splicing
- Autophagy in Disease and Therapy
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Cell death mechanisms and regulation
- FOXO transcription factor regulation
- Colorectal and Anal Carcinomas
- Cellular transport and secretion
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cardiac tumors and thrombi
Xiangya Hospital Central South University
2013-2024
Central South University
2013-2024
Changsha University
2017
In this study, we examined the clinical significance and molecular mechanisms of a long non-coding RNA (lncRNA), double homeobox A pseudogene 8 (DUXAP8) in hepatocellular carcinoma (HCC). DUXAP8 expression was compared using quantitative real-time PCR HCC versus adjacent tissues cell lines normal hepatic epithelial cells. The correlations between level clinicopathological features were analyzed. Assays including MTT, colony-forming analysis, Transwell assay, western blot, xenograft...
Background: The goal of this study is to assess the newest survival hepatoblastoma (HB) and risk factors which impacted on by using Surveillance, Epidemiology End Results (SEER) database, also calculate incidence HB in recent years. Methods: We age-adjusted SEER 21 registries. Age, sex, race, tumor size, macrovascular involvement, multifocal tumor, distant metastasis, way treatment, were collected for analysis prognostic 18 Survival curves, according different factors, obtained Kaplan-Meier...
Circ-CCT2 (hsa_circ_0000418) is a novel circular RNA that stems from the CCT2 gene. However, expression of circ-CCT2 and its roles in hepatoblastoma are unknown. Our study aims to development.
Background and Purpose Computerized tomography (CT) scans are commonly performed to assist in diagnosis treatment of locally advanced rectal cancer (LARC). This study assessed the usefulness pretreatment CT-based radiomics for predicting pathological complete response (pCR) LARC neoadjuvant chemoradiotherapy (nCRT). Materials Methods Patients with who underwent nCRT followed by total mesorectal excision surgery from July 2010 December 2018 were enrolled this retrospective study. A 340...
The altered faecal metabolites and microbiota might be involved in the development of breast cancer. We aimed to investigate effect differential on proliferative activity cancer cells.We collected samples from 14 patients healthy subjects. Untargeted metabolomics analysis, short-chain fatty acid (SCFA) targeted 16S rDNA sequencing was performed. gut metabolite composition changed significantly. Levels norvaline, glucuronate galacturonate were lower group than Control (p < 0.05)....
Hepatoblastoma (HB) is the most common malignant tumor of liver. MMP9 plays an essential role in HB. The purpose our study was to screen for differentially expressed lncRNAs and miRNAs that targeted MMP9. Based on this, lncRNA NEAT1/miR-132/MMP9 HB mechanisms involved were discussed.Bioinformatics analysis used targeting Exosomes extracted from cells normal liver characterization identification. Exosome uptake assay conducted determine whether exosomes absorbed by bone marrow stromal...
Pancreatic cancer (PC) is one of the most aggressive types with an extremely poor prognosis. Invasive growth and early metastasis greatest challenges to overcome for treatment PC. Numerous previous studies have indicated that transcription factor Krüppel-like 8 (KLF8) nuclear cofactor four a half LIM-only protein 2 (FHL2) serve important roles in tumorigenesis tumor progression; however, their PC remain elusive. The present study revealed KLF8 FHL2 expression aberrantly co-overexpressed...
Extracellular vesicles (EVs) can deliver miRNAs between cells and play a crucial role in hepatoblastoma progression. In this study, we explored the differentially expressed related to tumor cell-derived EVs mechanism by which regulate Bioinformatics analysis was performed explore adjacent normal tissues. TEM, NTA, western blotting were conducted identify EVs. The expression of miR-126-3p, miR-126-5p, miR-30b-3p, SRY, IL-1α, IL-6, TGF-β detected RT-qPCR. Immunofluorescence (IF) used analyze...
Abstract Background and Purpose Early detection of non‐response to neoadjuvant chemoradiotherapy (nCRT) for locally advanced colorectal cancer (LARC) remains challenging. We aimed assess whether pretreatment radiotherapy planning computed tomography (CT) radiomics could distinguish the patients with no response or downstaging after nCRT from those nCRT. Materials Methods Patients LARC who were treated retrospectively enrolled between March 2009 2019. Traditional radiological characteristics...
To characterize the imaging and clinicopathological features of primitive neuroectodermal tumors (PNETs) arising in intra-abdominal retroperitoneal regions.Eighteen patients with histopathologically proven PNET were enrolled; computed tomography was performed for all cases, magnetic resonance a single case. Typical findings, including morphology, texture enhancement features, as well characteristics prognosis data retrospectively analyzed.Of eighteen patients, fifteen male three female,...
Purpose: Adolescent and young adult (AYA) pancreatic ductal adenocarcinoma (PDAC) occurs in patients below 40 years old. Whether AYA have worse outcomes compared with older is still controversial. The purpose of this study to compare the after radical surgery for PDAC. Methods: A single-center, retrospective, cohort was conducted who underwent PDAC Xiangya Hospital Central South University from January 2007 December 2019. clinicopathological data results were collected analyzed...
Hepatoblastoma (HB) is the most common liver malignancy in pediatrics, but treatment for this disease minimal. This study aimed at exploring effect of FoxO1 and SREBP-1c on HB their mechanism.FoxO1, SREBP-1c, FASN, ACLY, ACC, MAGL expressions tissue samples were detected by RT-qPCR WB. IHC was utilized to measure FASN content. Overexpression knockdown sSREBP-1c performed Huh-6 cells. Cell proliferation, migration, invasion examined CCK8, scratch, transwell assay. ELISA test ATP, FAO, NEFA,...
Non-invasive prediction for KIT/PDGFRA status in GIST is a challenging problem. This study aims to evaluate whether CT based sarcopenia could differentiate wild-type gastrointestinal stromal tumor (wt-GIST) from the mutant-type (mu-GIST), and genetic features of GIST. A total 174 patients with (wt-GIST = 52) were retrospectively identified between January 2011 October 2019. nomogram was constructed by multivariate logistic regression. The performance evaluated discrimination, calibration...
Radiotherapy and chemotherapy can arrest cancer cells in a senescence-like state, which lead to therapy resistance relapse. mTOR is hyperactivated senescent but the mechanisms remain unclear. In this study, we examine roles of several mTOR-regulated GTPases liver drug resistance. We show that although RagC, Rheb, Rab1A, Rab5 Arf1 were required for optimal activation proliferating HepG2 cells, only RagC Rheb are counterparts. Consistently, be reduced by knocking down not other GTPases....
To investigate the simultaneous inhibition of X-linked inhibitor apoptosis protein (XIAP) and survivin expression on epithelial-mesenchymal transition (EMT) invasiion pancreatic cancer cells Panc-1, its mechanism.On established human Panc-1-XS, XIAP was inhibited simultaneously. Cell invasion migration were detected by Transwell chamber experiments scratch test, epithelial marker E-cadherin, mesenchymal markers Slug, phosphatase tensin homolog deleted chromosome ten (PTEN) P-Akt determined...