A5102908544- Dialysis and Renal Disease Management
- Renal Diseases and Glomerulopathies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Chronic Kidney Disease and Diabetes
- Ion channel regulation and function
- DNA Repair Mechanisms
- Muscle and Compartmental Disorders
- Nitric Oxide and Endothelin Effects
- Renal Transplantation Outcomes and Treatments
- Cannabis and Cannabinoid Research
- Electroconvulsive Therapy Studies
- Carcinogens and Genotoxicity Assessment
- Organ Donation and Transplantation
- Electrolyte and hormonal disorders
- Erythropoietin and Anemia Treatment
- Cell Adhesion Molecules Research
- Proteoglycans and glycosaminoglycans research
- Blood Pressure and Hypertension Studies
- Ion Transport and Channel Regulation
- Pharmacological Effects and Toxicity Studies
- Renal and Vascular Pathologies
- Autoimmune Neurological Disorders and Treatments
- Healthcare cost, quality, practices
- Angiogenesis and VEGF in Cancer
- Poisoning and overdose treatments
Tel Aviv University
2002-2024
Tel Aviv Sourasky Medical Center
2011-2023
Alzheimer's Association of Israel
2021
Rabin Medical Center
1987-2008
Pediatric Nephrology of Alabama
2005-2006
University of Toronto
1992-1994
Lev Hasharon Hospital
1990
Differential solute clearances were used to characterize glomerular function in 12 nondiabetic subjects with severe obesity (body mass index >38). Nine healthy served as the control group. In obese group, filtration rate (GFR) and renal plasma flow (RPF) exceeded value by 51 31%, respectively. Consequently, fraction increased. The augmented RPF suggested a state of vasodilatation involving, mainly or solely, afferent arteriole. Albumin excretion fractional albumin clearance increased 89 78%,...
We have generated homozygous transgenic mice (hpa-tg) overexpressing human heparanase (endo-beta-D-glucuronidase) in all tissues and characterized the involvement of enzyme tissue morphogenesis, vascularization, energy metabolism. Biochemical analysis heparan sulfate (HS) isolated from newborn adult revealed a profound decrease size HS chains derived hpa-tg vs. control mice. Despite this, appeared normal, were fertile, exhibited normal life span. A significant increase number implanted...
Glomerular epithelial cells (GEC) are a known site of vascular endothelial growth factor (VEGF) production. We established immortalized rat GEC, which retained the ability to produce VEGF. The isoforms expressed by GEC were defined as VEGF-205, -188, -120, and -164. electrical resistance cultured on GEC-conditioned matrix, an indicator permeability monolayers solutes, was significantly increased treatment with neutralizing polyclonal antibodies VEGF decreased VEGF-165. Transfection green...
Background. Uraemic patients have a decreased ability to withstand oxidative stress. It is postulated that their antioxidant capacity reduced, yet the mechanism remains unclear. Recently 33 haemodialysis (HD) were exposed chloramine contamination in water supply. This led haemolysis 24 patients, while nine unaffected. In former group haemoglobin from 11.7±1.1 8.5± 1.4 g/dl (P<0.0001) and returned 11.4±0.9 following recovery. During haemolysis, haptoglobin was 38.4±10.6 vs 138.1±8.3 ng/dl
Abstract. The surface area of the peritoneal membrane in contact with dialysate is an important determinant solute transport across peritoneum. Yet there no method for its estimation dialysis patients. In this study, stereologic methods were applied to computerized tomography (CT) imaging estimate area. was first validated by implementing on a phantom known distorted bottle filled contrast media. Series thin helical CT sections performed, and random obtained after reconstruction. A...
Non-occlusive mesenteric ischemia (NOMI) can be a fatal complication in dialysis patients. Intradialytic hypotension is usually the precipitating factor. The occurrence of 16 cases 5 years (1998-2002), compared with only 4 previous years, led us to investigate other risk factors contributing NOMI. A control group stable hemodialysis patients was used for comparison.20 were studied: 17 diagnosed surgically, and 3 clinically. mean age 70.8 +/- 1.8 male:female ratio 7:13. Nineteen on...
Only few studies of living kidney donors have included controls that were similarly healthy, including excellent function. In this study, we aimed to estimate long term metabolic and renal outcome in a cohort 211 compared two control groups: paired-matched controls, another group 2534 healthy individuals with Donors presented higher estimated Glomerular Filtration Rate (eGFR): (97.6 ± 15.2 vs 96.1 12.2 94.5 12.4 ml/min/1.73m2) lower urine albumin creatinine ratio (UACR) (4.3 5.9 6.1 6.9...
Background. Reactive oxygen species (ROS) play a key role in renal ischaemia–reperfusion injury. After establishing the vitro anti‐oxidative potential of mesna, sulfhydryl‐containing compound, its effect on kidney function and morphology rat model ischaemic acute failure (ARF) was examined. Methods. Mesna (180 mg/kg) administered at different time points relative to ischaemia and/or reperfusion onset. Kidney assessed by glomerular filtration rate (GFR) fractional sodium excretion (FENa)...
Anti-PLA2R antibodies (Ab) are a diagnostic and prognostic biomarker in primary membranous nephropathy (PMN). We assessed the relationship between levels of anti-PLA2R Ab at diagnosis different variables related to disease activity prognosis western population PMN patients. Forty-one patients with positive from three nephrology departments Israel were enrolled. Clinical laboratory data collected after one year follow-up, including serum (ELISA) glomerular PLA2R deposits on biopsy....
Glomerular epithelial cells (GEC) in culture are derived from intact isolated glomeruli. Although there is general agreement about distinguishing GEC mesangial and endothelial cells, still uncertainty regarding the visceral versus parietal origin of cultured GEC. If these to provide a useful model system, it necessary establish well-defined cell populations. The purpose this study was evaluate important issue by comparing characteristics with glomerular epithelium rat kidney sections. By...
Vascular endothelial growth factor (VEGF) is an endothelium-specific peptide that stimulates angiogenesis via two receptor tyrosine kinases, Flt-1 and KDR. Endothelial nitric oxide synthase (eNOS) plays a major role in VEGF signaling. Delivery of arginine to membrane bound eNOS by the cationic amino acid transporter-1 (CAT-1) has been shown modulate activity. The current studies were designed test hypothesis enhances activity modulation transport CAT-1.Using radio-labeled arginine, {[3H]...
Determining the dry weight of chronically hemodialysed patients is a common problem. Patients on intermittent hemodialysis often experience transient hoarseness at end dialysis. The vocal folds may be affected by hydration state.To test hypothesis that postdialysis related to changes in thickness folds.Twenty-five stable chronic underwent endoscopic nasopharyngeal laryngoscopy before and after Pictures were taken measured using computer software. Eighteen from 16 technically adequate for...
The secretion and activation of procollagenase IV were studied in cultured rat mesangial cells. Under resting conditions, cells secrete predominantly a protein that, by gel zymography, exhibits gelatinase activity also reacts with an anti-72-kd antibody raised against conserved region the site enzyme. Cytochalasin D or concanavalin A treatment causes disruption actin stress fibers results IV, yielding two lower molecular mass forms activity. Concanavalin A-induced filament can be blocked...
The familial disease of hereditary multiple exostoses is characterized by abnormal skeletal deformities requiring extensive surgical procedures. In patients there a shortage in the pericellular glycosaminoglycan (GAG) heparan sulfate (HS), related to defective activity HS glycosyltransferases, mainly regions chondrocytes. This study searched for novel approach employing xylosides with different aglycone groups priming variety GAG chains, attempting alter compositional profile. Cell cultures...
<i>Background:</i> Hemodialysis (HD) patients are subjected to increased oxidative stress. Oxidative stress causes DNA damage, which may be repaired by a repair system. ‘Spontaneous repair’ expresses of in vitro unstimulated cells. The aim the study was evaluate effect one HD session on spontaneous peripheral blood mononuclear cells (PBMC). <i>Methods:</i> PBMC were separated from samples for determination repair, measured <sup>3</sup>H-thymidine...