A5100362631- Immunotherapy and Immune Responses
- interferon and immune responses
- vaccines and immunoinformatics approaches
- Medical Research and Treatments
- Animal Disease Management and Epidemiology
- Immune cells in cancer
- Mycobacterium research and diagnosis
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Cancer Research and Treatments
- Viral Infections and Vectors
- RNA Interference and Gene Delivery
- Glioma Diagnosis and Treatment
- Immune Response and Inflammation
- Glycosylation and Glycoproteins Research
- Insect-Plant Interactions and Control
- SARS-CoV-2 detection and testing
- Inhalation and Respiratory Drug Delivery
- Cancer Immunotherapy and Biomarkers
- Endoplasmic Reticulum Stress and Disease
- Carbon and Quantum Dots Applications
- 2D Materials and Applications
- Inflammasome and immune disorders
- Viral Infectious Diseases and Gene Expression in Insects
- Nanopore and Nanochannel Transport Studies
Tsinghua University
2018-2024
Gene Tech (China)
2024
Fuzhou University
2024
Anhui Medical University
2024
Zhengzhou University
2024
Sichuan University
2022-2023
West China Hospital of Sichuan University
2022-2023
Binzhou University
2023
Binzhou Medical University
2023
West China Medical Center of Sichuan University
2022
Open AccessCCS ChemistryRESEARCH ARTICLES14 Jun 2022CASTING: A Potent Supramolecular Strategy to Cytosolically Deliver STING Agonist for Cancer Immunotherapy and SARS-CoV-2 Vaccination Jun-Jun Wu†, Fang-Yuan Chen†, Bei-Bei Han†, Hong-Qing Zhang†, Lang Zhao, Zhe-Rui Zhang, Juan-Juan Li, Bo-Dou Ya-Nan Yu-Xin Yue, Hong-Guo Hu, Wen-Hao Bo Yong-Xiang Chen, Dong-Sheng Guo Yan-Mei Li Wu† Key Lab of Bioorganic Phosphorus Chemistry Chemical Biology (Ministry Education), Department Chemistry, Center...
ConspectusCancer vaccines provide an efficient strategy to enhance tumor-specific immune responses by redeploying systems. Despite the approval of first cancer vaccine (Sipuleucel-T) U.S. Food and Drug Administration in 2010, most therapeutic fail clinical trials. Basically, rely on not only T-cell but also B-cell immunity, which indicates that should leverage both arms adaptive system. For example, CD8+ T cells activated antigen-presenting (APCs) recognize directly kill tumor via...
STING agonist cyclic di-GMP was applied to glycopeptide cancer vaccines through physical mixing and built-in strategies for the first time.
Constructing an effective therapeutic cancer vaccine is very attractive and promising for immunotherapy. However, the poor immunogenicity of tumor antigens suppression immune system in microenvironment are two major obstacles developing vaccines. Invariant NKT cells (iNKT cells), which essential bridges between innate adaptive systems, can be rapidly activated by their agonists and, consequently, evoke whole systems. Herein, we conjugated a potent agonist iNKT cell, α-galactosylceramide...
The protocol of aerobic oxidative dehydroxycyclization installed in the synthesis rarely studied 1-hydroxyphenothiazines from catechols and o-mercaptoanilines is presented. Utilizing a natural renewable low-toxicity gallic acid as an organocatalyst, this established transformation proceeded smoothly aqueous ethanol solution under mild conditions with good functional group compatibility up to 94% isolated yield. This also characterized by its operational simple workup involving only...
Encryption In article number 2306065, Kun Wang, Chaoxing Wu, Zhiqiang Liu, Tailiang Guo, Tae Whan Kim, and co-workers present a device-level encryption strategy by employing 3D confined electron system in which multiple pulses act as carriers for transmitted digital information, providing an alternative platform method converting signals to optical signals.
Large-scale outbreaks of scrub typhus combined with its emergence in new areas as a vector-borne rickettsiosis highlight the ongoing neglect this disease. This study aims to explore long-term changes and regional leading factors China, goal providing valuable insights for disease prevention control.
Cyclic dinucleotides (CDNs), agonists of stimulator interferon genes (STING), are promising agents for immunotherapy. However, the application CDNs has been limited by their instability and low transmembrane efficiency. Here, we introduced a conjugated adjuvant STING TLR1/2, Pam3CSK4-CDGSF. Conjugating CDGSF with Pam3CSK4 increased stability intracellular delivery. In addition, synergistically activating TLR pathways, Pam3CSK4-CDGSF was able to enhance immune activation. Both humoral...
Glycosylation of amyloidogenic proteins enhances their solubility and reduces propensity for aggregation. We therefore, prepared tryptophan-glucosamine conjugates to modulate aggregation tau-derived PHF6-peptide. Combined in vitro silico approaches indicated that these inhibited oligomerization fibril formation PHF6 disrupted its preformed fibrils at very low concentration. These effects mainly arise from the glucopyranoside moiety.
Glioma is the most common malignant tumor in central nervous system with no significant therapeutic breakthrough recent years. Most attempts to apply immunotherapy glioma have failed. Tryptophan and its metabolism can regulate features of cancers reshape immune microenvironment tumors. However, role tryptophan remains unclear. In current study, we explored relationships between expression pattern metabolism-related genes (TrMGs) characteristics, including prognosis gliomas through analyzing...
Diffuse gliomas possess a kind of malignant brain tumor with high mortality. Glutamine represents the most abundant and versatile amino acid in body. not only plays an important role cell metabolism but also involves survival malignancies progression. Recent studies indicate that glutamine could affect immune cells microenvironment (TME).The transcriptome data clinicopathological information patients glioma were acquired from TCGA, CGGA, West China Hospital (WCH). The metabolism-related...
Summary The Nlrp gene family contains 20 members and plays a pivotal role in the innate immune reproductive systems mouse. During evolution, seven Nlrp4 copies (named from Nlrp4a to Nlrp4g ). Nlrp4a–Nlrp4g have arisen that display specific or preferential ovarian expression patterns. However, pattern localization of mouse preimplantation embryo development are unknown. Here we report was highly expressed mature oocytes zygotes, then downregulated not detected after 2-cell stage. NLRP4G...
Background Ovarian cancer stands as a highly aggressive malignancy. The core aim of this investigation is to uncover genes pivotal the progression and prognosis ovarian cancer, while delving deep into intricate mechanisms that govern their impact.