A5069446464- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Hair Growth and Disorders
- T-cell and B-cell Immunology
- Dermatology and Skin Diseases
- Cytomegalovirus and herpesvirus research
- Immunotherapy and Immune Responses
- Mesenchymal stem cell research
- Cancer Immunotherapy and Biomarkers
- Pluripotent Stem Cells Research
Shenzhen Bioeasy Biotechnology (China)
2023-2024
Sun Yat-sen University
2020-2024
Abstract Stress‐induced hair loss is a prevalent health concern, with mechanisms that remain unclear, and effective treatment options are not yet available. In this study, we investigated whether stress‐induced was related to an imbalanced immune microenvironment. Screening the skin‐infiltrated cells in stressed mouse model, discovered significant increase macrophages upon stress induction. Clearance of rescues mice from shedding depletion follicle stem (HFSCs) skin, demonstrating role...
Abstract Objectives There are significant clinical challenges associated with alopecia treatment, including poor efficiency of related drugs and insufficient hair follicles (HFs) for transplantation. Skin‐derived precursors (SKPs) exhibit great potential as stem cell‐based therapies regeneration; however, the proliferation hair‐inducing capacity SKPs gradually decrease during culturing. Materials Methods We describe a 3D co‐culture system accompanied by kyoto encyclopaedia genes genomes gene...
Abstract Background Chimeric antigen receptor engineered T cells (CAR-T) have demonstrated promising clinical efficacy in B-cell malignancies, and the approach has been extended to T-cell malignancies. However, use of allogeneic CAR therapy poses a challenge due risk graft-versus-host disease. Recently, natural killer (NK) exhibited “off‑the‑shelf” availability. The nanobody-based structures attracted much attention for their therapeutic potential owing advantages nanobody, including small...
PD-L1 nanovesicles carrying rapamycin inhibit T cell activation to promote allograft acceptance.