A5101671777- Extracellular vesicles in disease
- Pregnancy and preeclampsia studies
- Fish Biology and Ecology Studies
- Immunotherapy and Immune Responses
- Aquaculture Nutrition and Growth
- Ginseng Biological Effects and Applications
- Prenatal Screening and Diagnostics
- RNA Interference and Gene Delivery
- Reproductive biology and impacts on aquatic species
- Advanced Nanomaterials in Catalysis
- Epigenetics and DNA Methylation
- RNA regulation and disease
- Fish Ecology and Management Studies
- Phytochemical compounds biological activities
- Leprosy Research and Treatment
- Tissue Engineering and Regenerative Medicine
- Virus-based gene therapy research
- Ocular Diseases and Behçet’s Syndrome
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Traditional Chinese Medicine Analysis
- Chemotherapy-induced organ toxicity mitigation
- Effects of Radiation Exposure
- Advanced biosensing and bioanalysis techniques
- Protease and Inhibitor Mechanisms
- Signaling Pathways in Disease
Macau University of Science and Technology
2024-2025
Nanjing Drum Tower Hospital
2024
China Pharmaceutical University
2023-2024
Xinjiang University
2024
Southwest University
2021-2023
Jiangnan University
2020-2023
Wuxi Fourth People's Hospital
2020-2023
Montefiore Health System
2021
St. Luke's Hospital
2020-2021
Icahn School of Medicine at Mount Sinai
2021
Excessive and persistent inflammation after injury lead to chronic wounds, increased tissue damage or even aggressive carcinogenic transformation. Effective wound repair could be achieved by inhibiting overactive immune cells the injured site. In this study, we obtained high concentration of PD-L1 in exosomes from either genetically engineered overexpressing IFN-γ stimulated cells. We found that exosomal is specially bound PD-1 on T cell surface, suppressed activation. Interestingly,...
Background/Aims: Cisplatin is widely used to treat malignancies. However, its major limitation the development of dose-dependent nephrotoxicity. The precise mechanisms cisplatin-induced kidney damage remain unclear. Previous study demonstrated central role mitochondrial ROS (mtROS) in pathogenesis cisplatin purpose this was explore mechanism mtROS regulation Methods: p53, MnSOD and p66shc were detected at mRNA protein levels by qPCR western blot HK2 cells. determined DCFDA MitoSOX staining....
T cell activation by immune allorecognition is a major contributing factor toward the triggering of organ rejection. Immunosuppressive drugs have to be taken after transplantation, but long-term use these increases risks infection and other serious disorders. Here, we showed dysregulation programmed death-ligand 1/programmed death 1 (PD-L1/PD-1) cytotoxic T-lymphocyte-associated protein 4/cluster differentiation 80 (CTLA-4/CD80) in spleen two transplantation models. Using bioengineering...
There is an urgent need for developing new immunosuppressive agents due to the toxicity of long-term use broad after organ transplantation. Comprehensive sample analysis revealed dysregulation FGL1/LAG-3 and PD-L1/PD-1 immune checkpoints in allogeneic heart transplantation mice clinical kidney transplant patients. In order enhance these two signal axes, a bioengineering strategy developed simultaneously display FGL1/PD-L1 (FP) on surface small extracellular vesicles (sEVs). Among various...
PD-L1 nanovesicles carrying rapamycin inhibit T cell activation to promote allograft acceptance.
The prognosis of patients with malignant melanoma has been improved in recent decades due to advancements immunotherapy. However, a considerable proportion are refractory treatment, particularly at advanced stages. This underscores the necessity developing new strategy improve it. Alternative polyadenylation (APA), as marker crucial posttranscriptional regulation, emerged major type epigenetic involved tumorigenesis. potential roles APA shaping tumor microenvironment (TME) largely...
Mutations in the plant homeodomain-like finger protein 6 (PHF6) gene are strongly associated with acute myeloid (AML) and T-cell lymphoblastic leukemia (T-ALL). In this study, we demonstrated that PHF6 can bind to H3K9me3 H3K27me1 on nucleolar chromatin recruit histone methyltransferase SUV39H1 rDNA locus. The deletion of caused a decrease recruitment loci, resulting reduction level promotion transcription. knockdown either or significantly attenuated effects increase suppressed...
Abstract There is an urgent need for developing new immunosuppressive agents due to the toxicity of long-term use broad post organ transplantation. Comprehensive sample analysis revealed dysregulation FGL1/LAG-3 and PD-L1/PD-1 immune checkpoints in allogeneic heart transplantation mice clinical kidney transplant patients. In order enhance these two signal axes, we developed a bioengineering strategy simultaneously display FGL1/PD-L1 (FP) on surface small extracellular vesicles (sEVs). Among...
Rheumatoid arthritis (RA) is a common type of chronic inflammatory disease. Elucidating the mechanism fibroblast-like synovial (FLS) as pathologic factor in RA may address urgent medical requirement for treatment RA. Isorhynchophylline (IRN) tetracyclic hydroxyindole alkaloid isolated from uncinaria, which has multiple biological activities and affects progression osteoarthritis. However, role IRN rheumatoid remains unclear. Herein, our study aimed to elucidate potential effect on reveal its...
Malignant melanoma has a poor prognosis because of its strong ability to invade tissues and metastasize. Immune checkpoint blockades significantly improve the clinical response in development melanoma. However, there are some obstacles overcome, such as cost limited application. Therefore, prospective approaches remain be exploited. We designed cellular nanovesicles (NVs) expressing PD-1 reactivate T cells by disrupting PD-1/PD-L1 immunoinhibitory pathway. Furthermore, siNF90 was wrapped...
Background: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by chronic inflammation and multiple organ damage, including in the female reproductive system. Mesenchymal stem cells (MSCs) have been widely studied for their anti-inflammatory regenerative effects shown to alleviate SLE. However, mechanism underlying how MSC transplantation SLE can improve ovarian function still not clear. The purpose of this study was investigate effect human umbilical cord-derived MSCs...
Abstract Herein, we demonstrate that NFAT, a key regulator of the immune response, translocates from cytoplasm to nucleolus and interacts with NF45/NF90 complex collaboratively promote rDNA transcription via triggering directly binding ARRE2-like sequences in promoter upon T cell activation vitro . The elevated pre-rRNA level cells is also observed both mouse heart or skin transplantation models, kidney transplanted patients. Importantly, can be significantly suppressed by inhibiting...
Introduction:We investigated whether placental tissue sampling site influences protein expression outcomes.Vascular endothelial growth factor (VEGF), VEGF 165 and b proteins were selected as candidate term delivered placentas from normotensive women was investigated.Methods: Maternal side of each 26 divided into four quadrants: North-East quadrant designated Q1, South-East Q2, South-West Q3 North-West Q4.Chorionic villi (CV) isolated sections quadrant.Pieces CV placed in separate tubes...