A5100696066- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Traditional Chinese Medicine Analysis
- Neurological Disease Mechanisms and Treatments
- RNA Interference and Gene Delivery
- Traditional Chinese Medicine Studies
- Cell Adhesion Molecules Research
- Flavonoids in Medical Research
- RNA modifications and cancer
- Advanced biosensing and bioanalysis techniques
- Protease and Inhibitor Mechanisms
- Cytomegalovirus and herpesvirus research
- Immune Cell Function and Interaction
- Cellular Mechanics and Interactions
- Acupuncture Treatment Research Studies
- Inflammasome and immune disorders
- Monoclonal and Polyclonal Antibodies Research
- Salivary Gland Disorders and Functions
- Plant chemical constituents analysis
- Inflammatory Biomarkers in Disease Prognosis
- Medicinal Plants and Bioactive Compounds
- Cardiac, Anesthesia and Surgical Outcomes
- Signaling Pathways in Disease
- Glycosylation and Glycoproteins Research
- Nanoparticle-Based Drug Delivery
Guangdong Academy of Medical Sciences
2025
Southern Medical University
2025
Guangdong Provincial People's Hospital
2025
Fudan University
2018-2024
Pudong Medical Center
2021-2024
Key Laboratory of Nuclear Radiation and Nuclear Energy Technology
2023
Kunming Medical University
2013-2023
Chinese People's Armed Police Force
2022
Heilongjiang Provincial Hospital
2022
Central South University
2005-2022
Three-dimensional (3D) culture models are considered to recapitulate the cell microenvironment in solid tumors, including extracellular matrix (ECM), cell-cell interactions, and signal transduction. These functions highly correlated with cellular behaviors contribute resistances against chemo- radio-therapies. However, biochemical effects mechanisms remain unknown soft sarcoma. Therefore, we developed an vitro 3D model of sarcoma analyze reasons radio-resistance therapies. Four lines,...
The Astragalus polysaccharides (APS) are important bioactive components of Astragali Radix, the dry root membranaceus, which has been used in traditional Chinese medicine. In this review, extraction conditions and rates APS first compared for water, microwave-assisted, ultrasonic wave, enzymatic hydrolysis methods. Some studies have also shown that different methods can be combined to improve rate APS. Subsequently, chemical composition structure discussed, as related purification method....
T cell activation by immune allorecognition is a major contributing factor toward the triggering of organ rejection. Immunosuppressive drugs have to be taken after transplantation, but long-term use these increases risks infection and other serious disorders. Here, we showed dysregulation programmed death-ligand 1/programmed death 1 (PD-L1/PD-1) cytotoxic T-lymphocyte-associated protein 4/cluster differentiation 80 (CTLA-4/CD80) in spleen two transplantation models. Using bioengineering...
Fusing visual understanding into language generation, Multi-modal Large Language Models (MLLMs) are revolutionizing visual-language applications. Yet, these models often plagued by the hallucination problem, which involves generating inaccurate objects, attributes, and relationships that do not match content. In this work, we delve internal attention mechanisms of MLLMs to reveal underlying causes hallucination, exposing inherent vulnerabilities in instruction-tuning process. We propose a...
BPD is a significant global health problem and currently lacks effective therapy. We established neonatal rat model of to investigate therapeutic potential BMSCs in lung disease. were isolated, identified, transfected by lentiviral vector carrying GFP gene vitro. Neonatal rats injected intravenously with either or PBS after they had been already exposed high oxygen for seven days, assessed on post-injection day 3, 7, 14 weight gaining, histology, radical alveolar counts, cytokine level....
Background/Aims . It is known that chronic low-grade inflammation contributes to the initiation and development of both diabetes diabetic nephropathy (DN), so we designed this study investigate role P2X7R NLRP3 inflammasome in DN pathogenesis antagonistic effects artificially cultivated Ophiocordyceps sinensis (ACOS). Methods A rat model caused by high-fat-diet feeding low-dose streptozotocin injection a mouse podocyte injury induced high-glucose (HG) stimulation were established,...
Radix Astragali is commonly used in traditional Chinese medicine, and its quality closely related to ecological factors, such as climate soil, the production area. To provide high-quality foreign markets, we maximum entropy model statistical analysis method, combined with data on Astragalus membranaceus var. mongholicus geographical distribution, index component content predict suitability distribution of A. establish relationship between astragaloside IV calycosin-7-glucoside this species...
Vein grafts in a coronary bypass or hemodialysis access often develop obliterative growth of the neointima. We previously reported that mechanical stretch-activated insulin-like factor-1 receptor (IGF-1/IGF-1R) pathway plays an important role this remodeling. However, transcriptional mechanism(s) regulating IGF-1R expression and neointima formation have not been identified.Deletion site-specific mutagenesis analysis promoter identified minimal mechano-responsive element (-270--130) contains...
Intrahepatic accumulation dominates organ distribution for most nanomedicines. However, obscure intrahepatic fate largely hampers regulation on their in vivo performance. Herein, PEGylated liposomal doxorubicin is exploited to clarify the of both liposomes and payload male mice. Kupffer cells initiate dominate capture doxorubicin, following deliver released hepatocytes with zonated along lobule porto-central axis. Increasing promotes hepatocytes, revealing capture-payload release-hepatocytes...
To clarify the mechanism of heat shock protein 27 (HSP27) as a diagnostic biomarker in coronary heart disease (CHD) and atherosclerosis (AS).Expressions HSP27 patients with CHD healthy controls were determined by enzyme-linked immunosorbent assay expressions aortas measured immunohistochemistry. Receiver operating characteristic curve was applied to assess performance CHD. ApoE-/- mice included accordingly grouped. The AS plaque quantitative real-time polymerase chain reaction,...
Abstract It has been hypothesized that human cytomegalovirus (HCMV) infection, especially in monocyte and CD34 (+) myeloid cells, acts as a important regulator of immune system to promote inflammation multiple autoimmune diseases. The aim this study was elucidate the HCMV gene expression profiles peripheral blood mononuclear cells (PBMCs) SLE patients demonstrate effect mechanism viral associated with mono-macrophages functions. Using two RNA-Seq techniques combination RT-PCR, 11 genes...
Staphylococcus aureus is an opportunistic human pathogen causing food-borne diseases. Therefore, the goal of present work was to develop a robust protocol for identification small amounts S. DNA in order establish rapid, sensitive, and simple method detect whether this species stool patients. A developed extraction by Fe₃O₄ @SiO₂ microbeads subsequent detection aureus-specific sequences loop-mediated isothermal amplification (LAMP). The LAMP technique rapid which allowsed bacteria at...