A5006338780- Extracellular vesicles in disease
- Immunotherapy and Immune Responses
- Wound Healing and Treatments
- Cytomegalovirus and herpesvirus research
- Diagnosis and Treatment of Venous Diseases
- Tendon Structure and Treatment
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Multiple Myeloma Research and Treatments
Sun Yat-sen University
2019-2022
Excessive and persistent inflammation after injury lead to chronic wounds, increased tissue damage or even aggressive carcinogenic transformation. Effective wound repair could be achieved by inhibiting overactive immune cells the injured site. In this study, we obtained high concentration of PD-L1 in exosomes from either genetically engineered overexpressing IFN-γ stimulated cells. We found that exosomal is specially bound PD-1 on T cell surface, suppressed activation. Interestingly,...
T cell activation by immune allorecognition is a major contributing factor toward the triggering of organ rejection. Immunosuppressive drugs have to be taken after transplantation, but long-term use these increases risks infection and other serious disorders. Here, we showed dysregulation programmed death-ligand 1/programmed death 1 (PD-L1/PD-1) cytotoxic T-lymphocyte-associated protein 4/cluster differentiation 80 (CTLA-4/CD80) in spleen two transplantation models. Using bioengineering...
Abstract Adipose stem cell‐derived exosomes have great potential in accelerating cutaneous wound healing by optimizing fibroblast activities. Recent studies demonstrated that play an active role the transport of functional cytoskeletal proteins such as vimentin. Previously we showed vimentin serves a coordinator process. Therefore, hypothesized incorporated into may contribute to mediate activities healing. Our results revealed exosomal from adipocyte progenitor cells acts promoter...
PD-L1 nanovesicles carrying rapamycin inhibit T cell activation to promote allograft acceptance.