A5048134771- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Circular RNAs in diseases
- Cell Adhesion Molecules Research
- Phagocytosis and Immune Regulation
- Cancer-related molecular mechanisms research
- Cellular Mechanics and Interactions
- Peptidase Inhibition and Analysis
- Cancer Mechanisms and Therapy
- Hippo pathway signaling and YAP/TAZ
- T-cell and B-cell Immunology
- Pancreatic function and diabetes
- Metastasis and carcinoma case studies
- Liver physiology and pathology
- Organ Transplantation Techniques and Outcomes
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Liver Disease Diagnosis and Treatment
- Caveolin-1 and cellular processes
- RNA Research and Splicing
- Hepatocellular Carcinoma Treatment and Prognosis
- Gallbladder and Bile Duct Disorders
- RNA modifications and cancer
- MicroRNA in disease regulation
First Affiliated Hospital of Anhui Medical University
2015-2025
Anhui Medical University
2015-2025
Anqing City Hospital
2024
The First Affiliated Hospital, Sun Yat-sen University
2002
Sun Yat-sen University
2002
BackgroundPatients undergoing surgical resection of hepatocellular carcinoma (HCC) are at risk recurrence; however, the underlying mechanism remains poorly understood.MethodsThrough analysis gene expression profiles in tumour and matched normal tissues from patients with (HCC), we identified differences interleukin-11 (IL-11) expression. Further, used genetic mouse, orthotopic tumour, chemically induced, allograft models to study correlation between IL-11 postsurgical recurrence....
Background and Aims: The innate-like mucosa-associated invariant T (MAIT) cells are enriched in human liver have been linked to HCC. However, their contributions the progression of HCC controversial due heterogeneity MAIT cells, new cell subsets remain be explored. Approach Results: Combining single RNA sequencing (scRNA-seq) flow cytometry analysis, we performed phenotypic functional studies found that FOXP3 + CXCR3 patients were regulatory (MAITregs) with high immunosuppressive potential....
Abstract Background Hepatocellular carcinoma (HCC) is an aggressive tumor with a poor clinical prognosis. Rupture of the fibrous capsule (FC) very important phenomenon in invasion and metastasis HCC. FC mainly composed type I collagen (COL1A1). However, it not clear what caused rupture. In this study, we aimed to determine whether rupture HCC patients was related macrophage-derived MMP-9 MMP-2, their diagnostic value for Results By performing immunohistochemical immunofluorescence staining...
Talin-1 (TLN-1) and TLN-2 are implicated in many cellular processes, but their roles hepatocellular carcinoma (HCC) remain unclear. This study aimed to assess cell cycle distribution, anoikis, invasion migration human HCC MHCC-97 L cells.MHCC-97 cells, which highly express TLN-1, were transduced with TLN-1 shRNA (experimental group) or scramble (negative control group); non-transduced cells used as blank controls. mRNA protein levels detected by real-time RT-PCR western blot, respectively....
Hepatic stellate cells (HSCs) are pivotal in the pathogenesis and progression of liver fibrosis. Their activation is characterized by increased expression integrin receptor αvβ3 elevated intracellular oxidative stress, leading to extracellular matrix deposition. To address these challenges, we developed a nanotechnology-driven drug delivery system for targeted transport curcumin (CUR) dihydromyricetin (DHM), two potential antifibrotic drugs with anti-inflammatory antioxidant properties, into...
Background: Talin-1 is a cytoskeleton protein that participates in cell migration and plays role tumor formation, migration, metastasis different types of cancer. Chinese investigators have observed the levels mRNA expression HCC tissues are significantly lower than adjacent non-cancerous tissue. However, Japanese reported upregulated HCC. Tln2 as homologous gene Tln-1, which encodes very similar protein, but Talin-2 little known primary liver cancer (PLC). We investigated whether PLC may be...
Gastric cancer is one of the most common cancers and second leading cause cancer‑associated mortality worldwide. Recurrence, metastasis resistance to drug treatment are main barrier survival patients with advanced stage gastric cancer. Further study molecular mechanisms involved will improve therapeutic options for In a previous study, c‑Maf was discovered as an oncogene transduced in avian AS42 retrovirus, found be overexpressed multiple myeloma angioimmunoblastic T‑cell lymphoma. inducing...
The effect of socioeconomic status (SES) on hepatocellular carcinoma (HCC) is still unclear, and there no nomogram integrated SES clinicopathological factors to predict the prognosis HCC. This research aims confirm effects predicting patients' survival establish a HCC.The data HCC patients were collected from Surveillance, Epidemiology, Final Results (SEER) database 2011 2015. (age at diagnosis, race sex, median family income, education level, insurance status, marital residence, cost living...
Circular RNAs (circRNAs) are stable and extensively distributed non-coding RNA molecules that differentially expressed in liver cancer tissues the human body. In this study, we aimed to investigate circRNA as a novel candidate biomarker for hepatocellular carcinoma (HCC). For three groups of HCC neighboring healthy tissues, circRNAs were identified through high-throughput sequencing analysis. Reverse transcription PCR (RT-PCR) quantitative polymerase chain reaction (qPCR) employed evaluation...
Hepatocellular carcinoma (HCC) is one of the most lethal malignancies, whose initiation and development are driven by alterations in driver genes. In this study, we identified four genes (TP53, PTEN, CTNNB1, KRAS) that show a high frequency somatic mutations or copy number variations (CNVs) patients with HCC. Four different spontaneous HCC mouse models were constructed to screen for changes various kinase signaling pathways. The sgTrp53 + sgPten tumor upregulated mTOR noncanonical nuclear...
Talin-1 is a known oncogene-associated protein. In this study, we set out to determine its role and mechanisms in hepatocellular carcinoma (HCC) progression. We found be highly expressed HCC cells relative non-cancer liver epithelial promote tumor growth metastasis. used Whole Human Genome Oligo Microarray analysis with which was knocked down using shRNA identify transcripts regulated by Talin-1. Of the 40,000 tested genes, 3099 were differentially after knockdown; expression of 1924 genes...
AIM: To identify the risk factors relating to early mortality after orthotopic liver transplantation.METHODS: Clinical data of 37 adult patients undergoing transplantation were retrospectively collected and divided into two groups: survived group (survival time 30 d) death time<30 d).The relationship between multivariate analyzed by stepwise logistic regression. RESULTS:The survival rate was 73%.Early 27%.APACAE, preoperative serum creatinine level interoperative bleeding quantity had a...
Prognostic significance of regional lymphadenectomy in T1b gallbladder cancer: Results from 24 hospitals China
Objective: To evaluate the clinical characteristics and prognosis of gallbladder cancer (GBC) patients in China. Methods: This retrospective multicenter cohort study enrolled 3 528 consecutive GBC diagnosed between January 2010 to December 2017 15 hospitals from 10 provinces. There were 1 345 (38.12%) males 2 183 (61.88%) females.The age diagnosis was (63.7±10.8) years old (range: 26 99 old) .There 213 (6.04%) stage 0 Ⅰ, whereas 059 (30.02%) Ⅱ Ⅲ, 874 (53.12%) Ⅳ, 382 (10.83%) unavailable....
Abstract Background Intrahepatic cholangiocarcinoma (ICC) is a malignant tumor originating from the secondary bile duct and its branch epithelium. Among primary liver tumors, incidence of ICC second only to hepatocellular carcinoma. Tumor microenvironment can regulate occurrence development tumors. This study dedicated finding more markers that diagnose by differential cells between normal tissues. Methods We wanted infiltration immune same patient paired non-tumor tissues, explore...
Background As one of the malignant tumors with highest incidence and fatality in world, colon adenocarcinoma (COAD) has a very complex pathogenic mechanism, which not yet been fully elucidated. Ubiquitin can regulate cell proliferation, cycle, apoptosis, DNA damage repair, other processes by changing activity substrate proteins or causing ubiquitin-proteasome degradation. These are key links pathogenesis COAD, ubiquitin plays an important role occurrence development COAD. Methods We...
The morbidity and mortality of pancreatic cancer have been continuously increasing, causing seven deaths per 100,000 individuals/year. At present, effective therapies are severely lacking, thus, highlighting the importance developing novel therapeutic approaches. present study aimed to investigate inhibitory roles 2,3‑oxidosqualene cyclase inhibitor, RO 48‑8071 (RO), on ductal adenocarcinoma. was used treat cell line (PANC‑1) in vitro examine effects viability, as well determine its...