A5040655120- Toxic Organic Pollutants Impact
- Neuroinflammation and Neurodegeneration Mechanisms
- Hydraulic Fracturing and Reservoir Analysis
- Drilling and Well Engineering
- Effects and risks of endocrine disrupting chemicals
- Cancer-related molecular mechanisms research
- Air Quality and Health Impacts
- Mitochondrial Function and Pathology
- MicroRNA in disease regulation
- Hydrocarbon exploration and reservoir analysis
- Carcinogens and Genotoxicity Assessment
- Reservoir Engineering and Simulation Methods
- Caveolin-1 and cellular processes
- Genomics, phytochemicals, and oxidative stress
- Lipid metabolism and disorders
- Transcranial Magnetic Stimulation Studies
- Circular RNAs in diseases
- Genetics, Aging, and Longevity in Model Organisms
- Microplastics and Plastic Pollution
- Coal Properties and Utilization
- Adenosine and Purinergic Signaling
- Nuclear Engineering Thermal-Hydraulics
- Cardiac Ischemia and Reperfusion
- Heat shock proteins research
- Neuropeptides and Animal Physiology
China National Petroleum Corporation (China)
2025
Nanjing University
2015-2024
Nanjing General Hospital of Nanjing Military Command
2016-2024
Nanjing Medical University
2016-2023
Jinling Institute of Technology
2021
State Key Laboratory of Pollution Control and Resource Reuse
2015-2020
Jiangsu University
2014-2018
Abstract Neuroinflammation is initiated in response to ischemic stroke, generally with the hallmarks of microglial activation and collateral brain injury contributed by robust inflammatory effects. Triggering receptor expressed on myeloid cells (TREM)-1, an amplifier innate immune response, a critical regulator inflammation. This study identified that TREM-1 expression was upregulated following cerebral injury. After pharmacologic inhibition synthetic peptide LP17, ischemia-induced...
Abstract Background Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive treatment for ischemic stroke. Astrocytes regulation has been suggested as one mechanism rTMS effectiveness. But how regulates astrocytes remains largely undetermined. There were neurotoxic and neuroprotective phenotypes of (also denoted classically alternatively activated or A1 A2 astrocytes) pertaining to pro- anti-inflammatory gene expression. Pro-inflammatory polarized induced during cerebral The...
Symptomatic intracranial hemorrhage (sICH), potentially associated with poor prognosis, is a major complication of endovascular thrombectomy (EVT) for ischemic stroke patients. We aimed to develop and validate risk model predicting sICH after EVT in Chinese patients due large-artery occlusions the anterior circulation.The derivation cohort recruited from Endovascular Treatment Acute Anterior Circulation Ischemic Stroke Registry China. was diagnosed according Heidelberg Bleeding...
Cellular oxidative stress plays a vital role in the pathological process of neural damage cerebral ischemia/reperfusion (I/R). The breast cancer susceptibility protein 1 (BRCA1), tumor suppressor, can modulate cellular antioxidant response and DNA repair. Yet BRCA1 I/R injury has not been explored. In this study, we observed that was mainly expressed neurons up-regulated to insult. Overexpression attenuated reactive oxygen species production lipid peroxidation. Enhanced expression promoted...
Thrombo-inflammation is an important checkpoint that orchestrates infarct development in ischemic stroke. However, the underlying mechanism remains largely unknown. Here, we explored role of endothelial Caveolin-1 (Cav-1) cerebral thrombo-inflammation.The correlation between serum Cav-1 level and clinical outcome was analyzed acute stroke patients with successful recanalization. Genetic manipulations by endothelial-specific adeno-associated virus (AAV) siRNA were applied to investigate...
Abstract Oligovascular coupling contributes to white matter vascular homeostasis. However, little is known about the effects of oligovascular interaction on oligodendrocyte precursor cell (OPC) changes in chronic cerebral ischemia. Here, using a mouse bilateral carotid artery stenosis, we show gradual accumulation OPCs vasculature with impaired oligodendrogenesis. Mechanistically, ischemia induces substantial loss endothelial caveolin-1 (Cav-1), leading secretion heat shock protein 90α...
Abstract Horizontal well staged fracturing is an important method for the development of unconventional reservoirs. It has been proved by field practice that effect not only related to reservoir oil and gas content, but also fracability reservoir, is, cluster perforation in"Engineering Sweet Spot " (ESP) area with strong can ensure uniform opening each maximize effect. Traditional engineering sweet spot evaluation methods involve logging interpretation core experiment，which have...
Oligodendrocytes express low-density lipoprotein receptor (LDLR) to endocytose cholesterol for the maintenance of adulthood myelination. However, potential role LDLR in chronic cerebral ischemia-related demyelination remains unclear. We used bilateral carotid artery stenosis (BCAS) induce sustained ischemia mice. This hypoxic-ischemic injury caused a remarkable decrease oligodendroglial LDLR, with impaired differentiation and survival. Oligodendroglial levels, however, remained unchanged....
Although activation of astrocytes is critical in developing neuropathic pain (NP) following nerve injury, the underlying mechanisms NP and therapeutic management for are still vague. Importantly, decreases levels astrocytic glutamate transporter-1 (GLT-1) spinal dorsal horn result enhanced excitatory transmission cause persistent pain. P2Y1 purinergic receptor (P2Y1R) has been shown to enhance many inflammatory processes. The up-regulated expression P2Y1R crucial participate transduction...
When brain injury happens, endogenous neural stem cells (NSCs) located in the adult subventricular zone (SVZ) and subgranular (SGZ) are attacked by ischemia/reperfusion to undergo cellular apoptosis death before being induced migrate lesion point differentiate into mature for damaged cell replacement. Although promoting antiapoptosis NSC survival critical neuroregeneration, mechanism has yet been elucidated clearly. Here this study, we established an vitro oxygen‐glucose deprivation...
Mitochondrial dysfunction is implicated in the pathology of neuronal damage during Alzheimer's disease (AD). Previous studies suggest that simvastatin (SV) ameliorates amyloid β (Aβ)‑mediated cognitive impairment AD patients and transgenic mice; however, mechanisms remain unknown. To investigate potential by which SV protects against neurotoxicity, present study used a series cellular molecular assays to analyze effects an vitro model Aβ1‑42-induced injury. The results demonstrated protected...
Stem cell survival after transplantation determines the efficiency of stem treatment, which develops as a novel potential therapy for several central nervous system (CNS) diseases in recent decades. The engrafted cells face damage oxidative stress, inflammation, and immune response at lesion point host. Among damaging pathologies, stress directs to apoptosis even death through signalling pathways DNA damage. However, in‐detail mechanism from has not been revealed clearly. Here, this study,...
Introduction: Neutrophil extracellular traps play a role in the pathophysiology of stroke and are associated with severity mortality. We aimed to investigate whether citrullinated histone H3 (CitH3), biomarker for neutrophil formation, is white matter lesion (WML) burden ischemic patients. Methods: Between September 2021 April 2022, 322 patients were enrolled this prospective observational cohort study. Serum CitH3 levels measured after admission using an enzyme-linked immunosorbent assay....
Numerical methods, such as finite element or difference, have been widely used in the past decades for modeling solid mechanics problems by solving partial differential equations (PDEs). Differently from traditional computational paradigm employed numerical physics-informed deep learning approximates physics domains using a neural network and embeds laws to regularize network. In this work, (PINN) is extended application linear elasticity that arise non-uniform deformation typical open-holed...