A5101473116- Pain Mechanisms and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Anesthesia and Sedative Agents
- Immune Response and Inflammation
- Neuropeptides and Animal Physiology
- Autophagy in Disease and Therapy
- Heme Oxygenase-1 and Carbon Monoxide
- Anesthesia and Pain Management
- Anesthesia and Neurotoxicity Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Mitochondrial Function and Pathology
- Pharmacological Effects of Natural Compounds
- Cardiac Arrest and Resuscitation
- Genomics, phytochemicals, and oxidative stress
- Neurological Disease Mechanisms and Treatments
- Hydrogen's biological and therapeutic effects
- Acupuncture Treatment Research Studies
- Neuroscience and Neuropharmacology Research
- S100 Proteins and Annexins
- Advanced Glycation End Products research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Botulinum Toxin and Related Neurological Disorders
- Glutathione Transferases and Polymorphisms
- Tryptophan and brain disorders
- Cardiac Ischemia and Reperfusion
Soochow University
2023
First Affiliated Hospital of Soochow University
2023
Nanjing General Hospital of Nanjing Military Command
2009-2019
Nanjing University
2009-2019
San Francisco VA Medical Center
2016-2017
University of California, San Francisco
2016-2017
Memorial Hospital of South Bend
2005-2014
Jinling Institute of Technology
2004-2012
Chinese Medical Association
2010
Marymount University
2010
Cathepsin S (CatS) is a cysteine protease normally present in lysosomes. It has long been regarded as an enzyme that primarily involved general protein degradation. More recently, mounting evidence shown it Alzheimer disease, seizures, age-related inflammatory processes, and neuropathic pain. In this study, we investigated the time course of CatS mRNA expression cellular distribution mouse model traumatic brain injury (TBI). To clarify roles TBI, injected mice intraventricularly with LHVS,...
2-Amino-2-[2-(4-octylphenyl)]-1,3-propanediol hydrochloride (FTY720), a synthetic compound from Isaria sinclairii, has been proven to possess various biological benefits including anti-cancer activity. However, the effects and related mechanisms of FTY720 on migration invasion glioblastoma cells are still unclear. In present study, we utilized U251MG U87MG human cell lines assess FTY720. We found that significantly inhibited cells. The anti-migration were associated with its down-regulation...
Brain injury resulting from stroke or trauma can be exacerbated by the release of proinflammatory cytokines, proteases, and reactive oxygen species activated microglia. The microglial activation brain is mediated in part alarmins, which are signaling molecules released damaged cells. nuclear enzyme poly(ADP‐ribose) polymerase‐1 (PARP‐1) has been shown to regulate after injury, here we show that effects alarmin S100B regulated PARP‐1. a protein localized predominantly astrocytes. Exogenous...
In Brief BACKGROUND: Intravascular volume therapy is crucial in septic patients to improve tissue perfusion and maintain stable hemodynamics. Modified fluid gelatins (MFG) medium weight hydroxyethyl starches (HES) are the most widely used synthetic colloids. Our aim this study, performed rats challenged by cecal ligation puncture (CLP), was investigate effects of HES MFG on pulmonary capillary leakage determine whether an antiinflammatory mechanism involved. METHODS: Animals were randomly...
Ketamine has been advocated for anesthesia in endotoxemic and other severely ill patients because it is a cardiovascular stimulant. However, ketamine also suppresses serum levels of endotoxin-induced tumor necrosis factor-alpha, reduces mortality mice endotoxin shock. Our study was designed to investigate the protective effect on proinflammatory cytokines nuclear factor kappa B (NF-kappaB) activation vivo.Adult male Wistar rats were randomly divided into six groups: saline controls;...