A5101961648- Olfactory and Sensory Function Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Metabolomics and Mass Spectrometry Studies
- Traditional Chinese Medicine Analysis
- Advanced Chemical Sensor Technologies
- Intensive Care Unit Cognitive Disorders
- Long-Term Effects of COVID-19
- Alzheimer's disease research and treatments
- Vagus Nerve Stimulation Research
- Nausea and vomiting management
- Bioinformatics and Genomic Networks
- Analytical Chemistry and Chromatography
- Music Therapy and Health
- Ginseng Biological Effects and Applications
- Advanced MRI Techniques and Applications
- Anesthesia and Neurotoxicity Research
- Adipose Tissue and Metabolism
- Natural product bioactivities and synthesis
- Trace Elements in Health
- Berberine and alkaloids research
- Hormonal and reproductive studies
- Alkaloids: synthesis and pharmacology
- Traditional Chinese Medicine Studies
- Traditional and Medicinal Uses of Annonaceae
- Connexins and lens biology
Xijing Hospital
2024-2025
Air Force Medical University
2024-2025
Tianjin haihe hospital
2024
Tianjin University of Traditional Chinese Medicine
2022-2024
Tongji University
2006-2024
Shanghai Tenth People's Hospital
2021-2022
Beijing Tian Tan Hospital
2022
Capital Medical University
2022
Sichuan Agricultural University
2019
Nanjing Medical University
2012
ObjectivesTo characterize the prevalence, severity, correlation with initial symptoms, and role of vaccination in patients COVID-19 smell or taste alterations (STAs).MethodsWe conducted an observational study infected SARS-CoV-2 Omicron admitted to three hospitals between May 17 June 16, 2022. The olfactory gustatory functions were evaluated using survey numerical visual analog scale at two time points.ResultsThe T1 T2 point assessments completed by 688 385 participants, respectively....
Pain management for herpes zoster-associated pain (ZAP) is essential to improve patients' daily lives and potentially intervene in the chronicity. Long-lasting, repetitive painful stimuli might lead central sensitization neuropathic generation. The subacute phase main period ZAP patients seek medical attention, it also a critical treatment time window transformation of chronic pathological changes. Although there still lack rigorous considerable sample evidence, degree incidence postherpetic...
Cerebral ischemia/reperfusion (I/R) injury is a serious condition that leads to increased apoptosis of microglial and neurons in the brain. In this study, we identified Cx43 expression level significantly cells during I/R injury. Using an vitro model (hypoxia/reoxygenation-H/R injury), observed H/R increase activation levels pro-inflammatory markers such as IL-1β, IL-6, TNF-α. Additionally, could also observe significant phosphorylation Cav3.2 levels. To assess role injured on neuronal...
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases and manifests as progressive memory loss cognitive dysfunction. Neuroinflammation plays an important role in development anti-inflammatory drugs reduce risk disease. However, immune microenvironment brains patients with remains unclear, mechanisms by which improve have not been clearly elucidated. This study aimed to provide overview cell composition entorhinal cortex based on transcriptomes signature genes...
Mammalian mitochondrial biogenesis is a complex process involving proliferation and differentiation. Mitochondrial DNA transcription factor A (
Precise identification and differentiation among those congeneric Traditional Chinese Medicines (TCMs) or derived from the same plant trend to be more challenging, particularly in absence of appearance characteristics. Three TCMs, involving Gleditsiae Sinensis Fructus (GSF), Abnormalis (GFA), Spina (GS), recorded Pharmacopoeia (2020 edition) are Gleditsia sinensis, but prescribed for different clinical uses. The documents aimed compare their chemical differences rare, date. An untargeted...
Alzheimer’s disease (AD) is the most common neurodegenerative among elderly and has become a growing global health problem causing great concern. However, pathogenesis of AD unclear no specific therapeutics are available to provide sustained remission disease. In this study, we used comprehensive bioinformatics determine 158 potential genes, whose expression levels changed between entorhinal temporal lobe cortex samples from cognitively normal individuals patients with AD. Then, clustered...
Abstract Aim The aim of this study is to explore the key mechanisms perioperative neurocognitive dysfunction (PND) after anesthesia/surgery (A/S) by screening hub genes. Methods Transcriptome sequencing was conducted on hippocampal samples obtained from 18‐month‐old C57BL/6 mice assigned control (Ctrl) and A/S groups. functionality differentially expressed genes (DEGs) investigated using Metascape. Hub associated with changes between two groups were screened combining weighted gene...
Ginsenosides and lipids are both bioactive ingredients for ginseng. Targeting these two categories of components, this study was designed to develop desorption electrospray ionization-mass spectrometry imaging approaches spatial metabolomics strategies, achieving the visualization differentiation among different parts Panax ginseng root (e.g., rhizome, main root, lateral fibrous adventitious root). Potential chemical markers were identified by searching an in-house ginsenoside library online...
Respiratory depression is a life-threatening adverse effect of deep sedation. This study aimed to investigate the factors related hypoxia caused by propofol during intravenous anesthesia.Three hundred and eight patients who underwent painless artificial abortion in outpatient department Shanghai Tenth People's Hospital between November 1, 2019 June 30, 2020 were divided into two groups according whether experienced (SpO2 < 95%). Preoperative anxiety assessments, anesthesia process,...
Alzheimer's disease (AD) is a fatal neurodegenerative disease, the etiology of which unclear. Previous studies have suggested that some viruses are neurotropic and associated with AD.By using bioinformatics analysis, we investigated potential association between viral infection AD.A total 5,066 differentially expressed genes (DEGs) in temporal cortex AD control samples were identified. These DEGs then examined via weighted gene co-expression network analysis (WGCNA) clustered into modules...
To describe the clinical characteristics of elderly patients with new-onset epilepsy in a Class A tertiary comprehensive hospital north China and evaluate treatment outcomes antiseizure medications (ASMs). This study focuses on investigating factors affecting outcomes, guiding drug treatment, judging prognosis patients.We included aged 60 years or older at time their first seizure between January 2014 August 2020. Demographic characteristics, effects ASM, proportion 1-year long-term freedom...
Postoperative systemic inflammatory dysregulation (PSID) is characterised by strongly interlinked immune and metabolic abnormalities. However, the hub genes responsible for interconnections between these two alterations remain to be identified.We analysed differentially expressed (DEGs) of individual peripheral blood nucleated cells in patients with PSID (n = 21, CRP > 250 mg/L) control 25, < 75 following major abdominal surgery, along their biological functions. Correlation analyses were...
Background This study aimed to investigate the effect of relaxation therapy on hypoxia during intravenous propofol anesthesia in patients with pre-operative anxiety. Methods Two-hundred and eighty were randomly categorized experimental group (relaxation group) control group. The Spielberger State-Trait Anxiety Inventory (S-STAI) was administered 30 60 min pre-operatively assess patient's current anxiety status select appropriate patients. Patients received pre-surgical therapy. Decrease...
<title>Abstract</title> <bold>Background</bold> Pain management for herpes zoster-associated pain (ZAP) is essential to improve patients’ daily lives and potentially intervene in the chronicity. Long-lasting, repetitive painful stimuli might lead central sensitization neuropathic generation. The subacute phase main period ZAP patients seek medical attention, it also a critical treatment time window transformation of chronic pathological changes. Although there still lack rigorous...
Severe interference from the endogenous substances is often encountered in characterizing drug metabolites by liquid chromatography/mass spectrometry using data-dependent acquisition (DDA). To add a precursor ions list (PIL) DDA or apply data-independent (DIA) coupled with post-acquisition data processing (such as mass defect filtering, MDF) may assist to target more complex biosamples. Dehydrocorynine (DHC) bioactive alkaloid compound rich Corydalis yanhusuo. We integrated both PIL-DDA and...
Summary Background Olfactory and gustatory dysfunctions (OGDs) are key symptoms of coronavirus disease 2019 (COVID-19), which may lead to neurological complications, lack effective treatment. This be because post-disease treatments too late protect the olfactory functions. Aim To evaluate effectiveness early use saline nasal irrigation (SNI), corticosteroid spray, or chlorhexidine gluconate mouthwash for preventing OGDs in COVID-19. Design study was a double-blind randomized controlled...