A5100323368- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Neural dynamics and brain function
- Olfactory and Sensory Function Studies
- Neuroscience and Neuropharmacology Research
- Advanced MRI Techniques and Applications
- Advanced Chemical Sensor Technologies
- Attention Deficit Hyperactivity Disorder
- Anesthesia and Neurotoxicity Research
- EEG and Brain-Computer Interfaces
- Long-Term Effects of COVID-19
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Intensive Care Unit Cognitive Disorders
- Genetics and Neurodevelopmental Disorders
- Memory and Neural Mechanisms
- Neonatal and fetal brain pathology
- Epilepsy research and treatment
- Diabetes and associated disorders
- Ion Channels and Receptors
- Migraine and Headache Studies
- Sport and Mega-Event Impacts
- Children's Physical and Motor Development
- Pancreatic function and diabetes
Beihang University
2022-2025
Ministry of Industry and Information Technology
2022-2025
Sichuan University of Science and Engineering
2023-2024
Hong Kong Polytechnic University
2023-2024
Fudan University
2021-2024
Xian Mental Health Center
2013-2024
Zhongda Hospital Southeast University
2024
Tongji University
2022-2024
East China Normal University
2016-2023
Zhongshan Hospital
2023
Dopamine neurons are thought to convey a fast, incentive salience signal, faster than can be mediated by dopamine. A resolution of this paradox may that midbrain dopamine exert fast excitatory actions. Using transgenic mice with fluorescent neurons, in which the axonal projections visible, we made horizontal brain slices encompassing mesoaccumbens projection. Focal extracellular stimulation ventral tegmental area evoked release and early monosynaptic late polysynaptic responses postsynaptic...
Type 2 diabetes mellitus (T2DM) alters brain function and manifests as atrophy. Intranasal insulin has emerged a promising intervention for treatment of cognitive impairment. We evaluated the acute effects intranasal on resting-state functional connectivity in older adults with T2DM. This proof-of-concept, randomized, double-blind, placebo-controlled study single 40 IU dose or saline 14 diabetic control subjects. Resting-state between hippocampal region default mode network (DMN) was...
Effective treatment as well prognostic biomarker for malignant esophageal squamous cell carcinoma (ESCC) is urgently needed. The present study was aimed at identifying oncogenic genes involving dysregulated intracellular Ca2+ signaling, which known to function importantly in cellular proliferation and migration. Tumors from patients with ESCC were found display elevated expression of Orai1, a store-operated entry (SOCE) channel, the high Orai1 associated poor overall recurrence-free...
Alzheimer's disease (AD) is a frequently observed, irreversible brain function disorder among elderly individuals. Resting-state functional magnetic resonance imaging (rs-fMRI) has been introduced as an alternative approach to assessing abnormalities in AD patients. However, alterations the rs-fMRI signal complexities mild cognitive impairment (MCI) and patients remain unclear. Here, we described novel application of permutation entropy (PE) investigate abnormal complexity signals MCI The 30...
The precuneus/posterior cingulate cortex, which has been associated with pain sensitivity, plays a pivotal role in the default mode network. However, information regarding migraine-related alterations resting-state brain functional connectivity network and local regional spontaneous neuronal activity is not adequate. This study used magnetic resonance imaging to acquire scans 22 migraineurs without aura healthy matched controls. Independent component analysis, data-driven method, was...
Cortical glutamate and substantia nigra dopamine (DA) afferents converge onto the dendritic spines of medium spiny neurons (MSNs) in striatum where they act to modulate motor cognitive functions. The released DA spills over from its synapse is thought regulate glutamatergic input by acting on distal receptors located corticostriatal axon terminals. By monitoring evoked release directly using fast-scan cyclic voltammetry, we report a reciprocal modulation spillover striatal release, induced...
ObjectivesTo characterize the prevalence, severity, correlation with initial symptoms, and role of vaccination in patients COVID-19 smell or taste alterations (STAs).MethodsWe conducted an observational study infected SARS-CoV-2 Omicron admitted to three hospitals between May 17 June 16, 2022. The olfactory gustatory functions were evaluated using survey numerical visual analog scale at two time points.ResultsThe T1 T2 point assessments completed by 688 385 participants, respectively....
Abstract Aging primarily affects memory and executive functions, a relationship that may be underpinned by the fact almost all adults over 60 years old develop small vessel disease (SVD). The wide range of neuropathologies could only explain up to 43% variation in age-related cognitive impairment suggests other factors, such as reserve, play role brain’s resilience against aging-related decline. This study aims examine between structural–functional-connectivity coupling (SFC), aging,...
Olfactory dysfunction (OD) is a common symptom in coronavirus disease 2019 (COVID-19) patients. Moreover, many neurological manifestations have been reported these patients, suggesting central nervous system involvement. The default mode network (DMN) closely associated with olfactory processing. In this study, we investigated the internetwork and intranetwork connectivity of DMN (ON) 13 healthy controls 22 patients presenting COVID-19-related OD using independent component analysis region...
Brain areas frequently implicated in language recovery after stroke comprise perilesional sites the left hemisphere and homotopic regions right hemisphere. However, neuronal mechanisms underlying restoration are still largely unclear.In present study, we investigated brain function 15 patients with poststroke aphasia 30 matched control subjects by combining regional homogeneity (ReHo) amplitudes of low-frequency fluctuation (ALFF) analysis methods based on resting-state fMRI.Compared to...
Background: Olfactory dysfunction (OD) is a common neurosensory manifestation in long COVID. An effective and safe treatment against COVID-19-related OD needed. Methods: This pilot trial recruited COVID patients with persistent OD. Participants were randomly assigned to receive short-course (14 days) oral vitamin A (VitA; 25,000 IU per day) aerosolised diffuser olfactory training (OT) thrice daily (combination), OT alone (standard care), or observation (control) for 4 weeks. The primary...
Non-conductive olfactory dysfunction (OD) is an important extra-pulmonary manifestation of coronavirus disease 2019 (COVID-19). Olfactory bulb (OB) volume loss and network functional connectivity (FC) defects were identified in two patients suffering from prolonged COVID-19-related OD. One patient received treatment (OT) by the combination oral vitamin A smell training via novel electronic portable aromatic rehabilitation (EPAR) diffusers. After four-weeks OT, clinical recuperation was...
Summary To find out the relationship between SNP genotypes of canine olfactory receptor genes and ability, 28 males 20 females from German Shepherd dogs in police service were scored by odor detection tests analyzed using Beckman GenomeLab stream. The representative 22 loci exonic regions 12 investigated, three kinds (human, ice drug trinitrotoluene) detected. results showed that at OR 10H1‐like: c.632C>T, c.770A>T, 2K2‐like: c.518G>A, 4C11‐like: c.511T>G c.692G>A had a...
Objective: Brain network studies have revealed abnormal topology asymmetry of white matter (WM) in ADHD. Recently, rich club organization was proposed to be a key feature brain topology. However, abnormalities the hemispheric WM networks ADHD remain unclear. Method: Forty patients and 51 normal controls participated this study. Structural were reconstructed based on diffusion tensor imaging (DTI) analyzed with graph theory. Results: The two groups exhibited different patterns connectivity...
Purpose: Growth hormone deficiency (GHD) refers to the partial or complete lack of growth hormone. Short stature and slow are characteristic patients with GHD. Previous neuroimaging studies have suggested that GHD may cause cognitive behavioral impairments in patients. Resting-state networks (RSNs) regions brain exhibit synchronous activity closely related our cognition behavior. Therefore, purpose current study was explore abnormalities children by investigating changes RSNs. Methods:...