A5100696853- Marine Invertebrate Physiology and Ecology
- Venomous Animal Envenomation and Studies
- Marine Toxins and Detection Methods
- Marine Sponges and Natural Products
- Pesticide Exposure and Toxicity
- Environmental Toxicology and Ecotoxicology
- Antimicrobial Peptides and Activities
- Nanoplatforms for cancer theranostics
- Geological and Geochemical Analysis
- High-pressure geophysics and materials
- Aquaculture disease management and microbiota
- Wound Healing and Treatments
- Pesticide and Herbicide Environmental Studies
- Nicotinic Acetylcholine Receptors Study
- Electrochemical Analysis and Applications
- Photodynamic Therapy Research Studies
- Cholinesterase and Neurodegenerative Diseases
- Bioactive Natural Diterpenoids Research
- Optical Coatings and Gratings
- Fluoride Effects and Removal
- Drug-Induced Adverse Reactions
- Advanced Drug Delivery Systems
- Heavy Metal Exposure and Toxicity
- Saffron Plant Research Studies
- Vibrio bacteria research studies
Shandong First Medical University
2023-2024
Shandong Provincial Institute of Dermatology and Venereology
2023-2024
Shandong Provincial Hospital
2024
Second Military Medical University
2011-2023
Propagation des Ondes : Étude Mathématique et Simulation
2022
Background Jellyfish contain diverse toxins and other bioactive components. However, large-scale identification of novel components from jellyfish has been hampered by the low efficiency traditional isolation purification methods. Results We performed de novo transcriptome sequencing tentacle tissue Cyanea capillata. A total 51,304,108 reads were obtained assembled into 50,536 unigenes. Of these, 21,357 unigenes had homologues in public databases, but remaining no significant matches due to...
Purpose: Pore-forming toxins (PFTs) perform important functions during bacterial infections. Among various virulence-targeting therapies, nanosponges (NSs) have excellent neutralization effects on multiple PFTs. To enhance treatment efficacy, NSs tend to be incorporated into other biomaterials, such as hydrogels. Methods: In the present work, red blood cell (RBC) vesicles were harvested wrap polymer nanoparticles, leading formation of NSs, and optimal Pluronic F127 hydrogel concentration was...
To investigate the hematologic changes and activities of jellyfish venoms other than hemolytic cardiovascular toxicities, acute toxicity tentacle-only extract (TOE) from Cyanea capillata was observed in mice, hematological indexes were examined rats. The median lethal dose (LD50) TOE 4.25 mg/kg, involved both heart- nervous system-related symptoms. Arterial blood gas indexes, including pH, PCO2, HCO3−, HCO3std, TCO2, BEecf BE (B), decreased significantly. PO2 showed a slight increase, while...
Cyclo-γ-PGA coated nanomicelles not only achieved photochemical internalization and photodynamic therapy but also realized controlled intracellular drug release.
The Yemaquan polymetallic skarn deposit is located in the Qimantagh metallogenic belt (QMB), northern Qinghai-Tibet Plateau, China, with total ore resources of 82.7 million metric tons at 29.46 percent Fe, 0.40% Cu, 2.08% Pb and 1.77% Zn. In this study, new trace element composition zircon tandem LA-ICP-MS U-Pb geochronology are provided for mineralized barren intrusive rocks occurring within two magnetic anomaly areas (M1 M13) deposit. These data, combined whole rock major compositions,...
Our previous studies have confirmed that the crude tentacle-only extract (cTOE) from jellyfish Cyanea capillata (Cyaneidae) exhibits hemolytic and cardiovascular toxicities simultaneously. So, it is quite difficult to discern underlying active component responsible for heart injury caused by cTOE. The inactivation of toxicity cTOE accompanied with a removal plenty precipitates would facilitate separation investigation its mechanism. In our research, after treatment one-step alkaline...
Our previous studies demonstrated that tentacle extract (TE) from the jellyfish, Cyanea capillata, could cause a dose-dependent increase of systolic blood pressure, which seemed to be result direct constriction vascular smooth muscle (VSM). The aim this study is investigate whether TE induce vasoconstriction in vitro and explore its potential mechanism. Using isolated aorta rings, contractile response was verified, showed concentration-dependent responses both endothelium-intact -denuded...
The scyphozoan jellyfish Cyanea capillata and Nemopilema nomurai are common blooming species in China. They possess heterogeneous nematocysts produce various types of venom that can elicit diverse sting symptoms humans. However, the differences composition between two remain unclear. In this study, a combined transcriptomic proteomic approach was used to identify compare putative toxins penetrant isolated from C. N. nomurai. A total 53 69 were identified nematocyst (CnV) (NnV), respectively....
Organophosphorus compounds (OPs) pose great military and civilian hazards. However, therapeutic prophylactic antidotes against OP poisoning remain challenging. In this study, we first developed a novel nanoscavenger (rOPH/ZIF-8@E-Lipo) methyl paraoxon (MP) using enzyme immobilization erythrocyte-liposome hybrid membrane camouflage techniques. Then, evaluated the physicochemical characterization, stability, biocompatibility of nanoscavengers. Afterward, examined acetylcholinesterase (AChE)...
Thioredoxin (Trx) plays a critical role in maintaining redox balance various cells and exhibits anti-oxidative, anti-apoptotic, anti-inflammatory effects. However, whether exogenous Trx can inhibit intracellular oxidative damage has not been investigated. In previous study, we have identified novel from the jellyfish Cyanea capillata, named CcTrx1, confirmed its antioxidant activities vitro. Here, obtained recombinant protein, PTD-CcTrx1, which is fusion of CcTrx1 protein transduction domain...
Organophosphate (OP)-induced delayed neurological damage is attributed to permanent neuropathological lesions caused by irreversible OP-neurocyte interactions, without potent brain-targeted etiological antidotes date. The development of alternative therapies achieve intracerebral OP detoxification urgently needed.We designed a nanoreactor integrating enzyme immobilization and biomimetic membrane camouflaging protocols with careful characterization, then examined its blood-brain barrier (BBB)...
IL-17A inhibitors have been identified as relatively safe and efficacious drugs against psoriasis since signalling plays a critical role in the pathogenesis.1 Nevertheless, side effects reported following treatment with inhibitors. Overall, hypersensitivity was 14.5% patients treated by ixekizumab. Among them, 0.9% of urticaria 0.5% were severe cases.2 Skin prick tests (SPT) intradermal (IDT) are commonly used diagnosis immediate reactions. However, both not devoid risk, especially for Other...
Our previous study demonstrated that tentacle extract (TE) from the jellyfish Cyanea capillata ( C. ) could cause a weak relaxation response mediated by nitric oxide (NO) using isolated aorta rings. However, intracellular mechanisms of TE-induced vasodilation remain unclear. Thus, this was conducted to examine role TE on Akt/eNOS/NO and Ca 2+ signaling pathways in human umbilical vein endothelial cells (HUVECs). results showed induced dose- time-dependent increases eNOS activity NO...
Wound healing is a complex biological process, and current research finds that jellyfish have great capacity for promoting growth healing. However, the underlying mechanisms remain unclear. Thus, this study was conducted to investigate molecular effects of tentacle extract (TE) from Cyanea capillata (C. capillata) on cell proliferation migration in human umbilical vein endothelial cells (HUVECs). First, our results showed TE at concentration 1 μg/ml could promote over various durations,...