A5101401716- Marine Invertebrate Physiology and Ecology
- Venomous Animal Envenomation and Studies
- Pesticide Exposure and Toxicity
- Nanoplatforms for cancer theranostics
- Marine Sponges and Natural Products
- Advanced biosensing and bioanalysis techniques
- Pacific and Southeast Asian Studies
- Archaeology and ancient environmental studies
- Connexins and lens biology
- Pesticide and Herbicide Environmental Studies
- Nanoparticle-Based Drug Delivery
- Wound Healing and Treatments
- Advanced Drug Delivery Systems
- Cultural Heritage Materials Analysis
- Rabies epidemiology and control
- IoT Networks and Protocols
- Marine Toxins and Detection Methods
- Pharmacological Effects and Toxicity Studies
- Age of Information Optimization
- Nicotinic Acetylcholine Receptors Study
- Insect and Pesticide Research
- Vibrio bacteria research studies
- Redox biology and oxidative stress
- Opportunistic and Delay-Tolerant Networks
- Photodynamic Therapy Research Studies
Northwest Normal University
2024
Second Military Medical University
2011-2023
Naval University of Engineering
2020
Henan Provincial Institute of Cultural Heritage and Archaeology
2018
Background Jellyfish contain diverse toxins and other bioactive components. However, large-scale identification of novel components from jellyfish has been hampered by the low efficiency traditional isolation purification methods. Results We performed de novo transcriptome sequencing tentacle tissue Cyanea capillata. A total 51,304,108 reads were obtained assembled into 50,536 unigenes. Of these, 21,357 unigenes had homologues in public databases, but remaining no significant matches due to...
Purpose: Pore-forming toxins (PFTs) perform important functions during bacterial infections. Among various virulence-targeting therapies, nanosponges (NSs) have excellent neutralization effects on multiple PFTs. To enhance treatment efficacy, NSs tend to be incorporated into other biomaterials, such as hydrogels. Methods: In the present work, red blood cell (RBC) vesicles were harvested wrap polymer nanoparticles, leading formation of NSs, and optimal Pluronic F127 hydrogel concentration was...
Cyclo-γ-PGA coated nanomicelles not only achieved photochemical internalization and photodynamic therapy but also realized controlled intracellular drug release.
Organophosphorus compounds (OPs) pose great military and civilian hazards. However, therapeutic prophylactic antidotes against OP poisoning remain challenging. In this study, we first developed a novel nanoscavenger (rOPH/ZIF-8@E-Lipo) methyl paraoxon (MP) using enzyme immobilization erythrocyte-liposome hybrid membrane camouflage techniques. Then, evaluated the physicochemical characterization, stability, biocompatibility of nanoscavengers. Afterward, examined acetylcholinesterase (AChE)...
Jellyfish stings are the most common marine animal injuries worldwide, with approximately 150 million envenomation cases annually, and victims may suffer from severe pain, itching, swelling, inflammation, arrhythmias, cardiac failure, or even death. Consequently, identification of effective first aid reagents for jellyfish envenoming is urgently needed. Here, we found that polyphenol epigallocatechin-3-gallate (EGCG) markedly antagonized hemolytic toxicity, proteolytic activity,...
Thioredoxin (Trx) plays a critical role in maintaining redox balance various cells and exhibits anti-oxidative, anti-apoptotic, anti-inflammatory effects. However, whether exogenous Trx can inhibit intracellular oxidative damage has not been investigated. In previous study, we have identified novel from the jellyfish Cyanea capillata, named CcTrx1, confirmed its antioxidant activities vitro. Here, obtained recombinant protein, PTD-CcTrx1, which is fusion of CcTrx1 protein transduction domain...
The scyphozoan jellyfish Cyanea capillata and Nemopilema nomurai are common blooming species in China. They possess heterogeneous nematocysts produce various types of venom that can elicit diverse sting symptoms humans. However, the differences composition between two remain unclear. In this study, a combined transcriptomic proteomic approach was used to identify compare putative toxins penetrant isolated from C. N. nomurai. A total 53 69 were identified nematocyst (CnV) (NnV), respectively....
Organophosphate (OP)-induced delayed neurological damage is attributed to permanent neuropathological lesions caused by irreversible OP-neurocyte interactions, without potent brain-targeted etiological antidotes date. The development of alternative therapies achieve intracerebral OP detoxification urgently needed.We designed a nanoreactor integrating enzyme immobilization and biomimetic membrane camouflaging protocols with careful characterization, then examined its blood-brain barrier (BBB)...
Wound healing is a complex biological process, and current research finds that jellyfish have great capacity for promoting growth healing. However, the underlying mechanisms remain unclear. Thus, this study was conducted to investigate molecular effects of tentacle extract (TE) from Cyanea capillata (C. capillata) on cell proliferation migration in human umbilical vein endothelial cells (HUVECs). First, our results showed TE at concentration 1 μg/ml could promote over various durations,...
Vibrio vulnificus (V. vulnificus) infection-associated multiple antibiotic resistance has raised serious public health concerns. Recently, nanosponges (NSs) have been expected to provide innovative platforms for addressing antibacterial and drug-resistant challenges by targeting various pore-forming toxins (PFTs). In the present study, we constructed NSs explore effects possible mechanism of recombinant V. hemolysin (rVvhA)-induced injuries. vitro, significantly reversed rVvhA-induced...
Sea snake venom is extremely toxic, and it can induce severe respiratory failure cause high mortality. The most effective first aid treatment for sea bites to inject antivenom as soon possible. However, in China, there are only four types of terrestrial antivenoms, none which the bites. In order develop an dominant species snakes Chinese seas, Hydrophis curtus (HcuV) was chosen antigen immunize horses. From immune plasma, a high-titer (HcuAV) prepared. vitro assessment showed that HcuAV had...