A5028537318- Immune cells in cancer
- Phagocytosis and Immune Regulation
- Eicosanoids and Hypertension Pharmacology
- Chemokine receptors and signaling
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Ferroptosis and cancer prognosis
- Liver Disease and Transplantation
- Cancer Immunotherapy and Biomarkers
- Hepatocellular Carcinoma Treatment and Prognosis
- Genetic Associations and Epidemiology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Lipids, and Metabolism
- Liver physiology and pathology
- Lung Cancer Research Studies
- Cancer, Hypoxia, and Metabolism
- interferon and immune responses
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Cancer-related gene regulation
Zhejiang University
2021-2024
Hangzhou First People's Hospital
2021-2024
University of Cambridge
2024
NIHR Cambridge Biomedical Research Centre
2024
Sir Run Run Shaw Hospital
2024
Zhejiang Chinese Medical University
2024
Institute of Hematology & Blood Diseases Hospital
2021
National Clinical Research Center for Digestive Diseases
2020
First Affiliated Hospital Zhejiang University
2020
Ferroptosis has garnered attention as a potential approach to fight against cancer, which is characterized by the iron-driven buildup of lipid peroxidation. However, robust defense mechanisms intracellular ferroptosis pose significant challenges its effective induction. In this paper, an gene delivery vehicle was developed transport solute carrier family 7 member 11 (SLC7A11) shRNA (shSLC7A11), downregulates expression channel protein SLC7A11 and glutathione peroxidase 4 (GPX4), evoking...
The efficacy of immune checkpoint inhibitors in the treatment hepatocellular carcinoma (HCC) remains limited, highlighting need for further investigation into mechanisms underlying resistance. Accumulating evidence indicates that tumor-associated macrophages (TAM) within tumor microenvironment demonstrate a key role evasion and This study explored TAMs HCC microenvironment. Our findings reveal expressing CX3C motif chemokine receptor 1 (CX3CR1) induced T-cell exhaustion through IL27...
Hepatocellular carcinoma (HCC) has a high rate of postoperative recurrence and lacks an effective treatment to prevent recurrence. This study aims investigate the efficacy safety anlotinib in adjuvant therapy for HCC patients with high-risk factors.For this multicenter, retrospective study, we recruited 63 who received either (n=27) or transcatheter arterial chemoembolization (TACE) (n=36) from six research centers China between March 2019 October 2020. The primary endpoint was disease-free...
<p>Supplementary Figure S4. The effect of different immunotherapy combinations on tumor infiltrating NK/NKT cells</p>
<p>Supplementary Figure S3. The effect of CX3CR1 neutralizing antibody on macrophages</p>
<p>Supplementary Fig S6. PGE2 released by tumor cells under immune attack promotes CX3CR1 upregulation on macrophages</p>
<p>Supplementary Fig S5. In vitro co-culture experiments of TAM and CD8<sup>+</sup> T cells the effect CX3CR1 overexpression on BMDMs</p>
<p>Table S1</p>
<p>Table S3</p>
<p>Supplementary Figure S1. Flow cytometry and FACS gating strategy</p>
Abstract Background The intricate relationship between the immune system and hepatocellular carcinoma (HCC) profoundly shapes its occurrence, progress, treatment, ultimate prognosis. While observational studies have uncovered robust correlations circulating traits HCC, genetic basis underlying these their potential causal connections to HCC remain unclear. Methods In this study, we employed on a bi-directional two-sample Mendelian randomization (MR) analysis, leveraging publicly accessible...
<div>Abstract<p>The efficacy of immune checkpoint inhibitors in the treatment hepatocellular carcinoma (HCC) remains limited, highlighting need for further investigation into mechanisms underlying resistance. Accumulating evidence indicates that tumor-associated macrophages (TAM) within tumor microenvironment demonstrate a key role evasion and This study explored TAMs HCC microenvironment. Our findings reveal expressing CX3C motif chemokine receptor 1 (CX3CR1) induced T-cell...
<p>Supplementary Figure S2. H22 orthotopic HCC immunotherapy model</p>
<p>Supplementary Fig S6. PGE2 released by tumor cells under immune attack promotes CX3CR1 upregulation on macrophages</p>
<p>Table S2</p>
Hepatocellular carcinoma (HCC) is a prevalent malignancy with poor survival. Different cell types in the tumor microenvironment participate tumorigenesis and progression of HCC. This study aimed to analyze immune HCC its relationship clinical outcomes.