A5083062484- Multiple Myeloma Research and Treatments
- Lymphoma Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Ubiquitin and proteasome pathways
- PI3K/AKT/mTOR signaling in cancer
- Cancer therapeutics and mechanisms
- Phytochemical compounds biological activities
- Acute Myeloid Leukemia Research
- Iron Metabolism and Disorders
- Cancer-related gene regulation
- Chronic Myeloid Leukemia Treatments
- Peptidase Inhibition and Analysis
- Mast cells and histamine
- Hemoglobinopathies and Related Disorders
- Natural Compounds in Disease Treatment
- Coccidia and coccidiosis research
- Cancer-related Molecular Pathways
- Cancer Mechanisms and Therapy
- Synthesis and Biological Activity
Nanjing Medical University
2021
Tongji University
2018-2021
Shanghai Tenth People's Hospital
2018-2021
Mantle cell lymphoma (MCL) is an aggressive and mostly incurable B-cell malignancy with frequent relapses after initial response to standard chemotherapy. Therefore, novel therapies are urgently required improve MCL clinical outcomes. In this study, lines were treated pterostilbene (PTE), a non-toxic natural phenolic compound primarily found in blueberries. The antitumor activity of PTE was examined by using the Cell Counting Kit-8, apoptosis assays, cycle analysis, JC-1 mitochondrial...
MCT-1 (multiple copies in T-cell lymphoma-1), a novel oncogene, was originally identified lymphoma. A recent study has demonstrated that is highly expressed 85% of diffuse large B-cell lymphomas (DLBCL). PKC (protein kinase C) plays an essential role signal transduction for multiple biologically active substances activating cellular functions and proliferation. In this study, we found the mRNA protein expression levels were visibly decreased after knocking down by siRNA SUDHL-4 OCI-LY8 DLBCL...
Abstract Background DCZ3301, a novel aryl-guanidino compound previously reported by our group, exerts cytotoxic effects against multiple myeloma (MM), diffused large B cell lymphoma (DLBCL), and T-cell leukemia/lymphoma. However, the underlying mechanism of its action remains unknown. Methods We generated bortezomib (BTZ)-resistant lines, treated them with various concentrations DCZ3301 over varying periods, studied effect on colony formation, proliferation, apoptosis, cycle, DNA synthesis,...
Mantle cell lymphoma (MCL) is a distinct and highly aggressive subtype of B-cell non-Hodgkin lymphoma. Dihydrocelastrol (DHCE) dihydro-analog celastrol, which isolated from the traditional Chinese medicinal plant Tripterygium wilfordii. The present study aimed to investigate effects DHCE treatment on MCL cells, determine mechanism underlying its potent antitumor activity in vitro vivo using Cell Counting kit-8 assay, clonogenic apoptosis cycle analysis, immunofluorescence staining, western...
<title>Abstract</title> Diffuse large B-cell lymphoma (DLBCL) is the most common category and disease entity of non-Hodgkin lymphoma. Osalmide pterostilbene are natural products with anticancer activities via different mechanism. In this study, using a new synthetic strategy for two products, we obtained compound DCZ0801, which was previously found to have anti-multiple myeloma activity. We performed both <italic>in vitro</italic> vivo</italic> assays investigate its bioactivity explore...
Multiple myeloma (MM) is the second most commonly diagnosed hematological malignancy. Understanding basic mechanisms of metabolism in MM may lead to new therapies that benefit patients. We collected gene expression profile data GSE39754 and performed differential analysis. Furthermore, identify candidate genes affect prognosis differentially expressed (DEGs) related metabolism. Enrichment analysis used biological effects genes. Perform coexpression on verified DEGs. In addition, are cluster...