A5069629618- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Pregnancy and preeclampsia studies
- Folate and B Vitamins Research
- Animal Genetics and Reproduction
- Ferroptosis and cancer prognosis
- Iron Metabolism and Disorders
- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Hemoglobinopathies and Related Disorders
Tongji University
2019-2023
Changhai Hospital
2022
Second Military Medical University
2022
East China Normal University
2018
Abstract Both circular RNAs (circRNAs) and cancer stem cells (CSCs) are separately known to be involved in cancer, but their interaction remains unclear. Here, the regulation of hepatocellular CSC self‐renewal is discovered by a circRNA, circ‐MALAT1, which produced back‐splicing long noncoding RNA, MALAT1. Circ‐MALAT1 highly expressed CSCs from clinical carcinoma samples under mediation an RNA‐binding protein, AUF1. Surprisingly, circMALAT1 functions as brake ribosomes retard PAX5 mRNA...
Due to differences across species, the mechanisms of cell fate decisions determined in mice cannot be readily extrapolated humans. In this study, we developed a feeder- and xeno-free culture protocol that efficiently induced human pluripotent stem cells (iPSCs) into PLZF+/GPR125+/CD90+ spermatogonium-like (SLCs). These SLCs were enriched with key genes germ development such as MVH, DAZL, GFRα1, NANOS3, DMRT1. addition, small fraction went through meiosis vitro develop haploid cells. We...
Abstract Cancer stem cells (CSCs) are the main cause of tumor development, metastasis, and relapse. CSCs thus considered promising targets for cancer therapy. However, it is hard to eradicate due their inherent plasticity heterogeneity, underlying mechanism switch between non‐CSCs remains unclear. Here, shown that miR‐135a combined with SMYD4 activates Nanog expression induces into CSCs. The level, once elevated, lowers methylation level CG5 site in promoter by directly targeting DNMT1....
Aim: To explore the function and underlying mechanism of MUC13 in hepatocellular carcinoma (HCC) oncogenesis. Materials & Methods: Online databases software were used to perform analyses expression, methylation enrichment pathway. Experiments performed confirm results using HCC cells vitro. Results: was upregulated liver cancer stem (CSCs) had a positive influence on CSC generation. Further revealed that with promoter hypomethylated regulated by DNA demethylase TET3, which overexpressed...
Objective: Liver cancer stem cells (CSCs) are the culprits of hepatocellular carcinoma metastasis and recurrence. Only by eliminating tumor can malignant tumors be fundamentally cured. This study aimed to identify role underlying mechanism aberrant Collagen Type XIV Alpha 1 Chain (COL14A1) overexpression in liver CSCs, improve understanding molecular basis Methods: First, quantitative real-time polymerase chain reaction was used confirm high-expression COL14A1 CSCs. Next, interference...
Serum ferritin levels have a clinical application in diagnosing diseases. However, the standard and distribution characteristics of serum based on reference intervals (RIs) geriatric Han Chinese population East China region not previously been well reported. This work aimed to investigate correlation between 14 metabolic markers, analyse ferritin, establish RIs for (> 60 years) individuals Shanghai.Four hundred sixty-nine healthy subjects (age, 61 - 95 years; median, 71 were recruited from...
Objective: Emerging data have shown that non-coding RNAs (ncRNAs) can encode micro-peptides (≤100 amino acids) play an important role in regulating physiological and pathological processes. Herein, we explored ncRNAs may are involved the development of hepatocellular carcinoma (HCC). Methods: High-throughput sequencing ribosomal protein S6 (RPS6) was performed four cancer cell lines using RNA-immunoprecipitation (RIP). UCSC databases obtained full length gene sequences quantitative...