A5055360295- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Nutritional Studies and Diet
- Regulation of Appetite and Obesity
- Muscle metabolism and nutrition
- Diet, Metabolism, and Disease
- Vitamin D Research Studies
- Sirtuins and Resveratrol in Medicine
- Biochemical Analysis and Sensing Techniques
- Metabolism, Diabetes, and Cancer
- Biochemical effects in animals
- Liver Disease Diagnosis and Treatment
- Sodium Intake and Health
- Parathyroid Disorders and Treatments
- Birth, Development, and Health
- Pancreatic function and diabetes
- Obesity, Physical Activity, Diet
- Pharmacology and Obesity Treatment
- Renal function and acid-base balance
- Hormonal Regulation and Hypertension
- Nutrition, Genetics, and Disease
- Blood Pressure and Hypertension Studies
- Nutrition and Health in Aging
- Vitamin C and Antioxidants Research
Health Affairs
2022
University of Tennessee at Knoxville
2007-2019
Ducks Unlimited
2019
Alliance for Multispecialty Research (United States)
2014
Oak Ridge National Laboratory
1997-2009
Knoxville College
2009
Quebec Rehabilitation Research Network
2006
Research Triangle Park Foundation
1998
Wayne State University
1983-1994
Augusta University Health
1993
Recent data from this laboratory demonstrate that increasing adipocyte intracellular Ca(2+) results in a coordinated stimulation of lipogenesis and inhibition lipolysis. We have also noted dietary calcium obese patients for 1 year resulted 4.9 kg loss body fat (P<0.01). Accordingly, we tested the possibility calcitrophic hormones may act on adipocytes to increase lipid metabolism by measuring effects 1, 25-(OH)(2)-D primary cultures human adipocytes, found significant, sustained increases...
Increasing 1,25-dihydroxyvitamin D in response to low-calcium diets stimulates adipocyte Ca2+ influx and, as a consequence, lipogenesis, suppresses lipolysis, and increases lipid accumulation, whereas increasing dietary calcium inhibits these effects markedly accelerates fat loss mice subjected caloric restriction. Our objective was determine the of face restriction humans.We performed randomized, placebo-controlled trial 32 obese adults. Patients were maintained for 24 weeks on balanced...
Abstract Objective : Our objective was to determine the effects of dairy consumption on adiposity and body composition in obese African Americans. Research Methods Procedures We performed two randomized trials African‐American adults. In first (weight maintenance), 34 subjects were maintained a low calcium (500 mg/d)/low (<1 serving/d) or high (1200 mg Ca/d diet including 3 servings dairy) with no change energy macronutrient intake for 24 weeks. second trial loss), 29 similarly diets...
We have demonstrated previously a regulatory role for intracellular Ca2+ ([Ca2+]i) in adipocyte lipogenesis and lipolysis recently reported that 1,25-(OH)2-D increases [Ca2+]i, which causes increased decreased lipolysis. now tested the hypothesis suppressing by increasing dietary calcium will suppress thereby facilitating weight loss stimulating inhibiting calorically (Kcal)-restricted (70% of ad lib) aP2-agouti transgenic (aP2-a) mice. Mice exhibiting pattern obesity gene expression similar...
A double-blind, positively controlled, forced dose titration study comparing the efficacy and safety of atenolol, captopril, verapamil sustained release as single agents in treatment black patients with mild to moderate hypertension (diastolic blood pressure, 95 114 mm Hg) was conducted. total 394 were randomized one three therapies. Mean pressures during a 2- 4-week placebo period (baseline) ranged from 100.4 100.7 Hg diastolic 151.7 152.5 systolic for groups. Of patients, 355 (of whom 345...
We reported recently that suppression of the renal 1alpha,25-dihyroxyvitamin D3 (1lpha,25-(OH)2-D3) production in aP2-agouti transgenic mice by increasing dietary calcium decreases adipocyte intracellular Ca2+ ([Ca2+]i), stimulates lipolysis, inhibits lipogenesis, and reduces adiposity. However, it was not clear whether this modulation metabolism is a direct effect inhibition 1alpha,25-(OH)2-D3-induced [Ca2+]i. Accordingly, we have now evaluated role 1alpha,25-(OH)2-D3. Human adipocytes...
Individuals exhibiting "the metabolic syndrome" have multiple coronary artery disease risk factors, including insulin resistance, hyperlipidemia, hypertension, and android obesity. We performed a randomized trial to compare the effects of aerobic resistance training regimens on factors. Twenty-six volunteers who exhibited obesity at least one other factor for were or groups. Body mass index, waist-to-hip ratio, glucose, insulin, body composition, 24-hr urinary albumin, fibrinogen, blood...
We investigated the mechanisms responsible for anti-lipolytic effect of intracellular Ca2+ ([Ca2+]i) in human adipocytes. Increasing [Ca2+]i inhibited lipolysis induced by b-adrenergic receptor activation, A1 adenosine inhibition, adenylate cyclase and phosphodiesterase (PDE) as well a hydrolyzable cAMP analog, but not nonhydrolyzable analog. This finding indicates that may be mediated activation adipocyte PDE. Consistent with this theory, inhibition isoproterenol-stimulated was reversed...
Intracellular calcium ([Ca(2+)](i)) modulates adipocyte lipid metabolism and inhibits the early stages of murine adipogenesis. Consequently, we evaluated effects increasing [Ca(2+)](i) in late human differentiation. Increasing with either thapsigargin or A23187 at 0-1 h differentiation markedly suppressed differentiation, a 40-70% decrease triglyceride accumulation glycerol-3 phosphate dehydrogenase (GPDH) activity (P < 0.005). However, 1-h pulse agent 47-48 only modestly inhibited...
Abstract Objective : Studies suggest that high‐dairy and high‐fiber/low‐glycemic index diets may facilitate weight loss, but data are conflicting. The effects on loss body fat of a diet high in dairy fiber low glycemic were compared with standard diet. Research Methods Procedures Ninety obese subjects recruited into randomized trial three designed to provide calorie deficit 500 calories/d over 48‐week period. study moderate (not low)‐calcium high‐calcium Results Seventy‐two completed the...
The effects of dairy on energy metabolism appear to be mediated, in part, by leucine and calcium which regulate both adipocyte skeletal muscle metabolism. We recently demonstrated that calcitriol fatty acid oxidation cells vitro, with promoting suppressing oxidation. Moreover, coordinately regulated lipid promote flux metabolic flexibility. have now investigated the role mitochondrial biogenesis mediating these effects.We tested effect leucine, regulation mass using a fluorescence method...